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Publikationer i urvalet

50 träffar

Bibliografisk träff 2022-10-06

Proline based rationally designed peptide esters against dipeptidyl peptidase-4: Highly potent anti-diabetic agents.

Vivesh, Kaur B, Jaglan S, Rani S, Batra Y, Singh P.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2022.129018

Bibliografisk träff 2021-11-12

Towards multi-target antidiabetic agents: In vitro and in vivo evaluation of 3,5-disubstituted indolin-2-one derivatives as novel α-glucosidase inhibitors.

Klochkov VG, Bezsonova EN, Dubar M, Melekhina DD, Temnov VV, Zaryanova EV, Lozinskaya NA, Babkov DA, Spasov AA.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2021.128449

Bibliografisk träff 2021-08-10

Identification and structure-activity relationship exploration of uracil-based benzoic acid and ester derivatives as novel dipeptidyl Peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus.

Li Q, Deng X, Jiang N, Meng L, Xing J, Jiang W, Xu Y.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113765

Bibliografisk träff 2021-08-10

A review upon medicinal perspective and designing rationale of DPP-4 inhibitors.

Kumar S, Mittal A, Mittal A.

Bioorg Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1016/j.bmc.2021.116354

Bibliografisk träff 2020-05-11

A cell-based fluorescent assay for FAP inhibitor discovery.

Zhang B, Liu F, Yang MF, Xu J, Wang Z, Zhang J, Wang R, Yang X.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2020.127253

Bibliografisk träff 2020-01-08

Anti-diabetic drugs recent approaches and advancements.

Dowarah J, Singh VP.

Bioorg Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1016/j.bmc.2019.115263

Bibliografisk träff 2019-10-25

Nitrothiadiazolo[3,2-a]pyrimidines as promising antiglycating agents.

Savateev K, Fedotov V, Butorin I, Eltsov O, Slepukhin P, Ulomsky E, Rusinov V, Litvinov R, Babkov D, Khokhlacheva E, Radaev P, Vassiliev P, Spasov A.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.111808

Bibliografisk träff 2019-07-16

Rapid generation of novel benzoic acid-based xanthine derivatives as highly potent, selective and long acting DPP-4 inhibitors: Scaffold-hopping and prodrug study.

Li Q, Meng L, Zhou S, Deng X, Wang N, Ji Y, Peng Y, Xing J, Yao G.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.07.045

Bibliografisk träff 2019-03-15

Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors.

Lozinskaya NA, Babkov DA, Zaryanova EV, Bezsonova EN, Efremov AM, Tsymlyakov MD, Anikina LV, Zakharyascheva OY, Borisov AV, Perfilova VN, Tyurenkov IN, Proskurnina MV, Spasov AA.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2019.03.028

Bibliografisk träff 2019-01-04

Identification of novel uracil derivatives incorporating benzoic acid moieties as highly potent Dipeptidyl Peptidase-IV inhibitors.

Huang J, Deng X, Zhou S, Wang N, Qin Y, Meng L, Li G, Xiong Y, Fan Y, Guo L, Lan D, Xing J, Jiang W, Li Q.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2019.01.001

Bibliografisk träff 2018-08-04

Pyrrole: An insight into recent pharmacological advances with structure activity relationship.

Ahmad S, Alam O, Naim MJ, Shaquiquzzaman M, Alam MM, Iqbal M.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2018.08.002

Bibliografisk träff 2018-07-11

Synthesis and evaluation of camphor and cytisine-based cyanopyrrolidines as DPP-IV inhibitors for the treatment of type 2 diabetes mellitus.

Kuranov SO, Tsypysheva IP, Khvostov MV, Zainullina LF, Borisevich SS, Vakhitova YV, Luzina OA, Salakhutdinov NF.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2018.07.018

Bibliografisk träff 2018-03-21

Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus.

Li N, Wang LJ, Jiang B, Li XQ, Guo CL, Guo SJ, Shi DY.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2018.03.041

Bibliografisk träff 2018-01-17

In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses.

Wang Y, Hu Y, Xu S, Zhang Y, Musharrafieh R, Hau RK, Ma C, Wang J.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.7b01536

Bibliografisk träff 2017-08-10

Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling.

Rea D, Van Elzen R, De Winter H, Van Goethem S, Landuyt B, Luyten W, Schoofs L, Van Der Veken P, Augustyns K, De Meester I, Fülöp V, Lambeir AM.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.08.024

Bibliografisk träff 2017-06-21

Influence of the cellular environment on ligand binding kinetics at membrane-bound targets.

Vanderheyden PML, Benachour N.

Bioorg Med Chem Lett · research support, non-u.s. gov't; review; journal article · DOI 10.1016/j.bmcl.2017.06.051

Bibliografisk träff 2016-08-04

Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure.

Schnapp G, Klein T, Hoevels Y, Bakker RA, Nar H.

J Med Chem · comparative study; journal article · DOI 10.1021/acs.jmedchem.6b00475

Bibliografisk träff 2014-08-19

Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors.

Ji X, Xia C, Wang J, Su M, Zhang L, Dong T, Li Z, Wan X, Li J, Li J, Zhao L, Gao Z, Jiang H, Liu H.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2014.08.059

Bibliografisk träff 2014-01-23

Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors.

Ji X, Su M, Wang J, Deng G, Deng S, Li Z, Tang C, Li J, Li J, Zhao L, Jiang H, Liu H.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2014.01.021

Bibliografisk träff 2014-01-06

Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV.

Namoto K, Sirockin F, Ostermann N, Gessier F, Flohr S, Sedrani R, Gerhartz B, Trappe J, Hassiepen U, Duttaroy A, Ferreira S, Sutton JM, Clark DE, Fenton G, Beswick M, Baeschlin DK.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2013.12.118

Bibliografisk träff 2013-10-24

Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else?

Juillerat-Jeanneret L.

J Med Chem · review; journal article · DOI 10.1021/jm400658e

Bibliografisk träff 2013-10-01

Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes.

Wang J, Feng Y, Ji X, Deng G, Leng Y, Liu H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2013.09.048

Bibliografisk träff 2013-09-25

Identification of a new class of glucokinase activators through structure-based design.

Hinklin RJ, Boyd SA, Chicarelli MJ, Condroski KR, DeWolf WE, Lee PA, Lee W, Singh A, Thomas L, Voegtli WC, Williams L, Aicher TD.

J Med Chem · journal article · DOI 10.1021/jm401116k

Bibliografisk träff 2013-08-16

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Morgan RE, van Staden CJ, Chen Y, Kalyanaraman N, Kalanzi J, Dunn RT, Afshari CA, Hamadeh HK.

Toxicol Sci · journal article · DOI 10.1093/toxsci/kft176

Bibliografisk träff 2013-07-25

Synthesis and biological evaluation of novel benzyl-substituted (S)-phenylalanine derivatives as potent dipeptidyl peptidase 4 inhibitors.

Liu Y, Si M, Tang L, Shangguan S, Wu H, Li J, Wu P, Ma X, Liu T, Hu Y.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2013.07.034

Bibliografisk träff 2013-04-06

Synthetic approaches to the 2011 new drugs.

Ding HX, Liu KK, Sakya SM, Flick AC, O'Donnell CJ.

Bioorg Med Chem · review; journal article · DOI 10.1016/j.bmc.2013.02.061

Bibliografisk träff 2012-12-12

Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available G protein-coupled receptor 119 agonists.

Katamreddy SR, Carpenter AJ, Ammala CE, Boros EE, Brashear RL, Briscoe CP, Bullard SR, Caldwell RD, Conlee CR, Croom DK, Hart SM, Heyer DO, Johnson PR, Kashatus JA, Minick DJ, Peckham GE, Ross SA, Roller SG, Samano VA, Sauls HR, Tadepalli SM, Thompson JB, Xu Y, Way JM.

J Med Chem · journal article · DOI 10.1021/jm301404a

Bibliografisk träff 2012-08-05

Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors.

Ikuma Y, Hochigai H, Kimura H, Nunami N, Kobayashi T, Uchiyama K, Furuta Y, Sakai M, Horiguchi M, Masui Y, Okazaki K, Sato Y, Nakahira H.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2012.07.046

Bibliografisk träff 2012-04-04

Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity.

Ryabtsova O, Jansen K, Van Goethem S, Joossens J, Cheng JD, Lambeir AM, De Meester I, Augustyns K, Van der Veken P.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2012.03.107

Bibliografisk träff 2012-03-28

Long-acting peptidomimetics based DPP-IV inhibitors.

Jadav P, Bahekar R, Shah SR, Patel D, Joharapurkar A, Kshirsagar S, Jain M, Shaikh M, Sairam KV.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2012.03.078