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Publikationer i urvalet

50 träffar

Bibliografisk träff 2005-09-28

Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors.

Ouyang X, Chen X, Piatnitski EL, Kiselyov AS, He HY, Mao Y, Pattaropong V, Yu Y, Kim KH, Kincaid J, Smith L, Wong WC, Lee SP, Milligan DL, Malikzay A, Fleming J, Gerlak J, Deevi D, Doody JF, Chiang HH, Patel SN, Wang Y, Rolser RL, Kussie P, Labelle M, Tuma MC.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2005.08.056

Bibliografisk träff 2005-02-01

Antimitotic activity and reversal of breast cancer resistance protein-mediated drug resistance by stilbenoids from Bletilla striata.

Morita H, Koyama K, Sugimoto Y, Kobayashi J.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2004.12.026

Bibliografisk träff 2005-02-01

Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines.

Simoni D, Grisolia G, Giannini G, Roberti M, Rondanin R, Piccagli L, Baruchello R, Rossi M, Romagnoli R, Invidiata FP, Grimaudo S, Jung MK, Hamel E, Gebbia N, Crosta L, Abbadessa V, Di Cristina A, Dusonchet L, Meli M, Tolomeo M.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm049622b

Bibliografisk träff 2004-12-01

Arylthioindoles, potent inhibitors of tubulin polymerization.

De Martino G, La Regina G, Coluccia A, Edler MC, Barbera MC, Brancale A, Wilcox E, Hamel E, Artico M, Silvestri R.

J Med Chem · journal article · DOI 10.1021/jm049360d

Bibliografisk träff 2004-08-01

Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.

Liou JP, Chang YL, Kuo FM, Chang CW, Tseng HY, Wang CC, Yang YN, Chang JY, Lee SJ, Hsieh HP.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm049802l

Bibliografisk träff 2004-07-01

A new family of quinoline and quinoxaline analogues of combretastatins.

Pérez-Melero C, Maya AB, del Rey B, Peláez R, Caballero E, Medarde M.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2004.04.098

Bibliografisk träff 2004-05-01

Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents.

Liou JP, Chang JY, Chang CW, Chang CY, Mahindroo N, Kuo FM, Hsieh HP.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0305974

Bibliografisk träff 2003-07-01

Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Prinz H, Ishii Y, Hirano T, Stoiber T, Camacho Gomez JA, Schmidt P, Düssmann H, Burger AM, Prehn JH, Günther EG, Unger E, Umezawa K.

J Med Chem · journal article · DOI 10.1021/jm0307685

Bibliografisk träff 2003-05-01

Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4.

Hadimani MB, Hua J, Jonklaas MD, Kessler RJ, Sheng Y, Olivares A, Tanpure RP, Weiser A, Zhang J, Edvardsen K, Kane RR, Pinney KG.

Bioorg Med Chem Lett · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(03)00206-3

Bibliografisk träff 2003-05-01

Novel 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents.

Sharma VM, Adi Seshu KV, Vamsee Krishna C, Prasanna P, Chandra Sekhar V, Venkateswarlu A, Rajagopal S, Ajaykumar R, Deevi DS, Rao Mamidi NV, Rajagopalan R.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(03)00263-4

Bibliografisk träff 2003-04-01

Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A.

Mu F, Hamel E, Lee DJ, Pryor DE, Cushman M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm020292+

Bibliografisk träff 2003-02-01

Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides.

Pettit GR, Anderson CR, Herald DL, Jung MK, Lee DJ, Hamel E, Pettit RK.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm020204l

Bibliografisk träff 2003-01-01

Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents.

Hsieh HP, Liou JP, Lin YT, Mahindroo N, Chang JY, Yang YN, Chern SS, Tan UK, Chang CW, Chen TW, Lin CH, Chang YY, Wang CC.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(02)00850-8

Bibliografisk träff 2002-06-01

Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate.

Pettit GR, Grealish MP, Jung MK, Hamel E, Pettit RK, Chapuis JC, Schmidt JM.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm010119y

Bibliografisk träff 2002-06-01

Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents.

Liou JP, Chang CW, Song JS, Yang YN, Yeh CF, Tseng HY, Lo YK, Chang YL, Chang CM, Hsieh HP.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm010365+

Bibliografisk träff 2002-06-01

One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization.

Flynn BL, Hamel E, Jung MK.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm020077t

Bibliografisk träff 2002-04-01

Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation.

Wang L, Woods KW, Li Q, Barr KJ, McCroskey RW, Hannick SM, Gherke L, Credo RB, Hui YH, Marsh K, Warner R, Lee JY, Zielinski-Mozng N, Frost D, Rosenberg SH, Sham HL.

J Med Chem · journal article · DOI 10.1021/jm010523x

Bibliografisk träff 2002-02-01

Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent.

Li Q, Woods KW, Claiborne A, Gwaltney SL, Barr KJ, Liu G, Gehrke L, Credo RB, Hui YH, Lee J, Warner RB, Kovar P, Nukkala MA, Zielinski NA, Tahir SK, Fitzgerald M, Kim KH, Marsh K, Frost D, Ng SC, Rosenberg S, Sham HL.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(01)00759-4

Bibliografisk träff 2001-12-01

Combretoxazolones: synthesis, cytotoxicity and antitumor activity.

Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(01)00622-9

Bibliografisk träff 2001-11-01

Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.

Xia Y, Yang ZY, Xia P, Hackl T, Hamel E, Mauger A, Wu JH, Lee KH.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm0101085

Bibliografisk träff 2001-09-01

The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4.

Flynn BL, Flynn GP, Hamel E, Jung MK.

Bioorg Med Chem Lett · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(01)00436-x

Bibliografisk träff 2001-05-01

Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones.

Xia Y, Yang ZY, Hour MJ, Kuo SC, Xia P, Bastow KF, Nakanishi Y, Namrpoothiri P, Hackl T, Hamel E, Lee HK.

Bioorg Med Chem Lett · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/s0960-894x(01)00190-1

Bibliografisk träff 2001-04-01

Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.

Gwaltney SL, Imade HM, Barr KJ, Li Q, Gehrke L, Credo RB, Warner RB, Lee JY, Kovar P, Wang J, Nukkala MA, Zielinski NA, Frost D, Ng SC, Sham HL.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(01)00098-1

Bibliografisk träff 2001-02-01

Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization.

Mu F, Coffing SL, Riese DJ, Geahlen RL, Verdier-Pinard P, Hamel TE, Johnson J, Cushman M.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm000387g

Bibliografisk träff 2001-01-01

Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.

Lawrence NJ, Rennison D, Woo M, McGown AT, Hadfield JA.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(00)00596-5

Bibliografisk träff 2000-11-01

Design, synthesis and cytotoxic activities of naphthyl analogues of combretastatin A-4.

Maya AB, del Rey B, Lamamie de Clairac RP, Caballero E, Barasoain I, Andreu JM, Medarde M.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(00)00506-0

Bibliografisk träff 2000-11-01

6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

Hour MJ, Huang LJ, Kuo SC, Xia Y, Bastow K, Nakanishi Y, Hamel E, Lee KH.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm000151c

Bibliografisk träff 2000-07-01

Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug.

Pettit GR, Grealish MP, Herald DL, Boyd MR, Hamel E, Pettit RK.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm000045a

Bibliografisk träff 2000-07-01

Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1, 2-dihydroxy- 1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3' ',4' ',5' '-trimethoxyphenyl)-ethane.

Pettit GR, Lippert JW, Herald DL, Hamel E, Pettit RK.

J Nat Prod · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/np0000623

Bibliografisk träff 2000-04-01

Bioactive compounds from Combretum erythrophyllum.

Schwikkard S, Zhou BN, Glass TE, Sharp JL, Mattern MR, Johnson RK, Kingston DG.

J Nat Prod · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/np9904410