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Publikationer i urvalet

50 träffar

Bibliografisk träff 2019-08-22

New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation.

Brunetti L, Loiodice F, Piemontese L, Tortorella P, Laghezza A.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.9b00885

Bibliografisk träff 2019-03-04

N-Cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites.

Chandrabalan A, McPhillie MJ, Morice AH, Boa AN, Sadofsky LR.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.02.074

Bibliografisk träff 2018-10-11

Tetrazolylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability.

Garzinsky D, Zahov S, Ekodo Voundi M, Hanekamp W, Lehr M.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.10.021

Bibliografisk träff 2018-09-04

Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit.

Spadoni G, Bedini A, Furiassi L, Mari M, Mor M, Scalvini L, Lodola A, Ghidini A, Lucini V, Dugnani S, Scaglione F, Piomelli D, Jung KM, Supuran CT, Lucarini L, Durante M, Sgambellone S, Masini E, Rivara S.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.8b00893

Bibliografisk träff 2018-01-04

Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.

Kodani SD, Bhakta S, Hwang SH, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD.

Bioorg Med Chem Lett · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2018.01.003

Bibliografisk träff 2017-05-12

Novel propanamides as fatty acid amide hydrolase inhibitors.

Deplano A, Morgillo CM, Demurtas M, Björklund E, Cipriano M, Svensson M, Hashemian S, Smaldone G, Pedone E, Luque FJ, Cabiddu MG, Novellino E, Fowler CJ, Catalanotti B, Onnis V.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.05.033

Bibliografisk träff 2017-03-02

Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase.

De Simone A, Russo D, Ruda GF, Micoli A, Ferraro M, Di Martino RM, Ottonello G, Summa M, Armirotti A, Bandiera T, Cavalli A, Bottegoni G.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.6b01578

Bibliografisk träff 2017-02-17

Biological evaluation of pyridone alkaloids on the endocannabinoid system.

Chicca A, Berg R, Jessen HJ, Marck N, Schmid F, Burch P, Gertsch J, Gademann K.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2017.02.031

Bibliografisk träff 2017-01-30

(Indolylalkyl)piperidine carbamates as inhibitors of fatty acid amide hydrolase (FAAH).

Dahlhaus H, Hanekamp W, Lehr M.

Medchemcomm · research-article; journal article · DOI 10.1039/c6md00683c

Bibliografisk träff 2016-11-15

1-Heteroarylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability.

Zahov S, Garzinsky D, Hanekamp W, Lehr M.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2016.11.025

Bibliografisk träff 2016-11-14

Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.

Tuo W, Leleu-Chavain N, Spencer J, Sansook S, Millet R, Chavatte P.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.6b00538

Bibliografisk träff 2016-06-28

Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents.

Montanari S, Scalvini L, Bartolini M, Belluti F, Gobbi S, Andrisano V, Ligresti A, Di Marzo V, Rivara S, Mor M, Bisi A, Rampa A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.6b00609

Bibliografisk träff 2016-04-23

Design, synthesis and biological evaluation of potent FAAH inhibitors.

Tuo W, Leleu-Chavain N, Barczyk A, Renault N, Lemaire L, Chavatte P, Millet R.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2016.04.004

Bibliografisk träff 2016-02-22

Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties.

Pember SO, Mejia GL, Price TJ, Pasteris RJ.

Bioorg Med Chem Lett · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2016.02.061

Bibliografisk träff 2015-12-23

Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.

Migliore M, Habrant D, Sasso O, Albani C, Bertozzi SM, Armirotti A, Piomelli D, Scarpelli R.

Eur J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ejmech.2015.12.036

Bibliografisk träff 2015-05-05

Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH).

Aghazadeh Tabrizi M, Baraldi PG, Ruggiero E, Saponaro G, Baraldi S, Romagnoli R, Martinelli A, Tuccinardi T.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2015.04.064

Bibliografisk träff 2014-07-12

Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist.

Brizzi A, Aiello F, Marini P, Cascio MG, Corelli F, Brizzi V, De Petrocellis L, Ligresti A, Luongo L, Lamponi S, Maione S, Pertwee RG, Di Marzo V.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2014.07.006

Bibliografisk träff 2014-04-10

Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.

Chobanian HR, Guo Y, Liu P, Chioda MD, Fung S, Lanza TJ, Chang L, Bakshi RK, Dellureficio JP, Hong Q, McLaughlin M, Belyk KM, Krska SW, Makarewicz AK, Martel EJ, Leone JF, Frey L, Karanam B, Madeira M, Alvaro R, Shuman J, Salituro G, Terebetski JL, Jochnowitz N, Mistry S, McGowan E, Hajdu R, Rosenbach M, Abbadie C, Alexander JP, Shiao LL, Sullivan KM, Nargund RP, Wyvratt MJ, Lin LS, DeVita RJ.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml5001239

Bibliografisk träff 2014-01-28

Switching cannabinoid response from CB(2) agonists to FAAH inhibitors.

Tourteau A, Leleu-Chavain N, Body-Malapel M, Andrzejak V, Barczyk A, Djouina M, Rigo B, Desreumaux P, Chavatte P, Millet R.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2014.01.056

Bibliografisk träff 2013-10-22

Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.

Patel JZ, Parkkari T, Laitinen T, Kaczor AA, Saario SM, Savinainen JR, Navia-Paldanius D, Cipriano M, Leppänen J, Koshevoy IO, Poso A, Fowler CJ, Laitinen JT, Nevalainen T.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm400923s

Bibliografisk träff 2013-02-15

Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.

Ortar G, Morera E, De Petrocellis L, Ligresti A, Schiano Moriello A, Morera L, Nalli M, Ragno R, Pirolli A, Di Marzo V.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2013.02.005

Bibliografisk träff 2013-02-08

(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).

Holtfrerich A, Hanekamp W, Lehr M.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2013.01.050

Bibliografisk träff 2012-12-19

Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography.

Wilson AA, Hicks JW, Sadovski O, Parkes J, Tong J, Houle S, Fowler CJ, Vasdev N.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm301492y

Bibliografisk träff 2012-11-29

An unprecedented reversible mode of action of β-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH).

Feledziak M, Michaux C, Lambert DM, Marchand-Brynaert J.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2012.11.035

Bibliografisk träff 2012-11-15

Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.

Kono M, Matsumoto T, Kawamura T, Nishimura A, Kiyota Y, Oki H, Miyazaki J, Igaki S, Behnke CA, Shimojo M, Kori M.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2012.11.006

Bibliografisk träff 2012-07-26

Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.

Butini S, Brindisi M, Gemma S, Minetti P, Cabri W, Gallo G, Vincenti S, Talamonti E, Borsini F, Caprioli A, Stasi MA, Di Serio S, Ros S, Borrelli G, Maramai S, Fezza F, Campiani G, Maccarrone M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm300689c

Bibliografisk träff 2012-06-14

Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors.

Kapanda CN, Masquelier J, Labar G, Muccioli GG, Poupaert JH, Lambert DM.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm3006004

Bibliografisk träff 2012-06-06

Assay and inhibition of diacylglycerol lipase activity.

Johnston M, Bhatt SR, Sikka S, Mercier RW, West JM, Makriyannis A, Gatley SJ, Duclos RI.

Bioorg Med Chem Lett · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2012.05.101

Bibliografisk träff 2012-02-07

Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels.

Bianchi BR, Zhang XF, Reilly RM, Kym PR, Yao BB, Chen J.

J Pharmacol Exp Ther · journal article · DOI 10.1124/jpet.111.189902

Bibliografisk träff 2012-01-21

The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?

Rampa A, Bartolini M, Bisi A, Belluti F, Gobbi S, Andrisano V, Ligresti A, Di Marzo V.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml200313p