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Publikationer i urvalet

37 träffar

Bibliografisk träff 2022-12-01

Pharmacologically induced endolysosomal cholesterol imbalance through clinically licensed drugs itraconazole and fluoxetine impairs Ebola virus infection in vitro.

Kummer S, Lander A, Goretzko J, Kirchoff N, Rescher U, Schloer S.

Emerg Microbes Infect · research-article; journal article · DOI 10.1080/22221751.2021.2020598

Bibliografisk träff 2022-03-04

Efficient Cholesterol Transport in Dendritic Cells Defines Optimal Exogenous Antigen Presentation and Toxoplasma gondii Proliferation.

Croce C, Garrido F, Dinamarca S, Santi-Rocca J, Marion S, Blanchard N, Mayorga LS, Cebrian I.

Front Cell Dev Biol · research-article; journal article · DOI 10.3389/fcell.2022.837574

Bibliografisk träff 2022-02-11

Novel Insights Into Sterol Uptake and Intracellular Cholesterol Trafficking During Eimeria bovis Macromeront Formation.

Silva LMR, Velásquez ZD, López-Osorio S, Hermosilla C, Taubert A.

Front Cell Infect Microbiol · research support, non-u.s. gov't; research-article; journal article · DOI 10.3389/fcimb.2022.809606

Bibliografisk träff 2021-11-29

The Compound U18666A Inhibits the Intoxication of Cells by Clostridioides difficile Toxins TcdA and TcdB.

Papatheodorou P, Kindig S, Badilla-Lobo A, Fischer S, Durgun E, Thuraisingam T, Witte A, Song S, Aktories K, Chaves-Olarte E, Rodríguez C, Barth H.

Front Microbiol · research-article; journal article · DOI 10.3389/fmicb.2021.784856

Bibliografisk träff 2021-10-26

Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology.

Wu Q, Cortez L, Kamali-Jamil R, Sim V, Wille H, Kar S.

Dis Model Mech · research support, non-u.s. gov't; research-article; journal article · DOI 10.1242/dmm.048929

Bibliografisk träff 2021-08-30

The Antihypertensive Drug Telmisartan Protects Oligodendrocytes from Cholesterol Accumulation and Promotes Differentiation by a PPAR-γ-Mediated Mechanism.

Bernardo A, Malara M, Bertuccini L, De Nuccio C, Visentin S, Minghetti L.

Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms22179434

Bibliografisk träff 2021-08-27

Suppression of neuronal cholesterol biosynthesis impairs brain functions through insulin-like growth factor I-Akt signaling.

Liu T, Li Y, Yang B, Wang H, Lu C, Chang AK, Huang X, Zhang X, Lu Z, Lu X, Gao B.

Int J Biol Sci · research support, non-u.s. gov't; research-article; journal article · DOI 10.7150/ijbs.63512

Bibliografisk träff 2021-08-01

Reversal of apolipoprotein E4-dependent or chemical-induced accumulation of APP degradation products by vitamin C-induced release of heparan sulfate from glypican-1.

Cheng F, Fransson LÅ, Mani K.

Glycobiology · research support, non-u.s. gov't; journal article · DOI 10.1093/glycob/cwaa120

Bibliografisk träff 2021-06-19

Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation.

Torres S, Solsona-Vilarrasa E, Nuñez S, Matías N, Insausti-Urkia N, Castro F, Casasempere M, Fabriás G, Casas J, Enrich C, Fernández-Checa JC, Garcia-Ruiz C.

Redox Biol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.redox.2021.102052

Bibliografisk träff 2021-05-27

NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry.

Li G, Su B, Fu P, Bai Y, Ding G, Li D, Wang J, Yang G, Chu B.

Sci China Life Sci · research-article; journal article · DOI 10.1007/s11427-021-1929-y

Bibliografisk träff 2021-04-27

Phagocytic and pinocytic uptake of cholesterol in Tetrahymena thermophila impact differently on gene regulation for sterol homeostasis.

Hernández J, Gabrielli M, Costa J, Uttaro AD.

Sci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41598-021-88737-z

Bibliografisk träff 2021-01-01

Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms.

Xiao X, Kim Y, Romartinez-Alonso B, Sirvydis K, Ory DS, Schwabe JWR, Jung ME, Tontonoz P.

Proc Natl Acad Sci U S A · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1073/pnas.2024149118

Bibliografisk träff 2020-01-18

In Vivo Antiviral Effects of U18666A Against Type I Feline Infectious Peritonitis Virus.

Doki T, Tarusawa T, Hohdatsu T, Takano T.

Pathogens · research-article; journal article · DOI 10.3390/pathogens9010067

Bibliografisk träff 2019-10-03

U18666A inhibits classical swine fever virus replication through interference with intracellular cholesterol trafficking.

Liang XD, Zhang YN, Liu CC, Chen J, Chen XN, Sattar Baloch A, Zhou B.

Vet Microbiol · journal article · DOI 10.1016/j.vetmic.2019.108436

Bibliografisk träff 2019-06-06

Bafilomycin A1 and U18666A Efficiently Impair ZIKV Infection.

Sabino C, Basic M, Bender D, Elgner F, Himmelsbach K, Hildt E.

Viruses · research support, non-u.s. gov't; research-article; journal article · DOI 10.3390/v11060524

Bibliografisk träff 2018-05-15

Endosomal-Lysosomal Cholesterol Sequestration by U18666A Differentially Regulates Amyloid Precursor Protein (APP) Metabolism in Normal and APP-Overexpressing Cells.

Chung J, Phukan G, Vergote D, Mohamed A, Maulik M, Stahn M, Andrew RJ, Thinakaran G, Posse de Chaves E, Kar S.

Mol Cell Biol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/mcb.00529-17

Bibliografisk träff 2018-04-17

Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors.

Capuzzi SJ, Sun W, Muratov EN, Martínez-Romero C, He S, Zhu W, Li H, Tawa G, Fisher EG, Xu M, Shinn P, Qiu X, García-Sastre A, Zheng W, Tropsha A.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.8b00035

Bibliografisk träff 2017-08-03

The cholesterol transport inhibitor U18666A inhibits type I feline coronavirus infection.

Takano T, Endoh M, Fukatsu H, Sakurada H, Doki T, Hohdatsu T.

Antiviral Res · research-article; journal article · DOI 10.1016/j.antiviral.2017.07.022

Bibliografisk träff 2017-07-19

Effects of cholesterol transport inhibitor U18666A on APP metabolism in rat primary astrocytes.

Yang H, Wang Y, Kar S.

Glia · journal article · DOI 10.1002/glia.23191

Bibliografisk träff 2017-06-20

U18666A, an activator of sterol regulatory element binding protein pathway, modulates presynaptic dopaminergic phenotype of SH-SY5Y neuroblastoma cells.

Schmitt M, Dehay B, Bezard E, Garcia-Ladona FJ.

Synapse · research support, non-u.s. gov't; journal article · DOI 10.1002/syn.21980

Bibliografisk träff 2016-11-28

The Intracellular Cholesterol Transport Inhibitor U18666A Inhibits the Exosome-Dependent Release of Mature Hepatitis C Virus.

Elgner F, Ren H, Medvedev R, Ploen D, Himmelsbach K, Boller K, Hildt E.

J Virol · research-article; journal article · DOI 10.1128/jvi.01053-16

Bibliografisk träff 2016-09-24

Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly.

Quach D, Vitali C, La FM, Xiao AX, Millar JS, Tang C, Rader DJ, Phillips MC, Lyssenko NN.

Biochim Biophys Acta · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bbalip.2016.09.017

Bibliografisk träff 2016-01-27

The mechanism of the effect of U18666a on blocking the activity of 3β-hydroxysterol Δ-24-reductase (DHCR24): molecular dynamics simulation study and free energy analysis.

Quan X, Chen X, Sun D, Xu B, Zhao L, Shi X, Liu H, Gao B, Lu X.

J Mol Model · research support, non-u.s. gov't; journal article · DOI 10.1007/s00894-016-2907-2

Bibliografisk träff 2015-12-08

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection.

Lu F, Liang Q, Abi-Mosleh L, Das A, De Brabander JK, Goldstein JL, Brown MS.

Elife · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.7554/elife.12177

Bibliografisk träff 2015-09-07

U18666A Treatment Results in Cholesterol Accumulation, Reduced Na(+), K(+)-ATPase Activity, and Increased Oxidative Stress in Rat Cortical Astrocytes.

Copetti-Santos D, Moraes V, Weiler DF, de Mello AS, Machado Fde S, Marinho JP, Siebert C, Kolling J, Funchal C, Wyse AT, Coelho JC.

Lipids · journal article · DOI 10.1007/s11745-015-4062-4

Bibliografisk träff 2015-09-04

Protective Effect of DHT on Apoptosis Induced by U18666A via PI3K/Akt Signaling Pathway in C6 Glial Cell Lines.

Yao K, Wu J, Zhang J, Bo J, Hong Z, Zu H.

Cell Mol Neurobiol · research-article; journal article · DOI 10.1007/s10571-015-0263-x

Bibliografisk träff 2015-02-17

Effect of u18666a on beta-glucosidase, sphingomyelinase, and beta-galactosidase activities in astrocytes of young rats.

Santos DC, da Silva Garcia C, de Andrade CV, Daitx VV, da Costa Moraes V, Rohden F, Coelho JC.

J Membr Biol · journal article · DOI 10.1007/s00232-014-9761-x

Bibliografisk träff 2014-09-02

Comparison of the anti-prion mechanism of four different anti-prion compounds, anti-PrP monoclonal antibody 44B1, pentosan polysulfate, chlorpromazine, and U18666A, in prion-infected mouse neuroblastoma cells.

Yamasaki T, Suzuki A, Hasebe R, Horiuchi M.

PLoS One · comparative study; research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0106516

Bibliografisk träff 2012-12-17

Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.

Amritraj A, Wang Y, Revett TJ, Vergote D, Westaway D, Kar S.

J Biol Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1074/jbc.m112.412460

Bibliografisk träff 2011-11-29

U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication.

Poh MK, Shui G, Xie X, Shi PY, Wenk MR, Gu F.

Antiviral Res · research support, non-u.s. gov't; journal article · DOI 10.1016/j.antiviral.2011.11.014

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Publikationer i urvalet

Pharmacologically induced endolysosomal cholesterol imbalance through clinically licensed drugs itraconazole and fluoxetine impairs Ebola virus infection <i>in vitro</i>.

Efficient Cholesterol Transport in Dendritic Cells Defines Optimal Exogenous Antigen Presentation and Toxoplasma gondii Proliferation.

Novel Insights Into Sterol Uptake and Intracellular Cholesterol Trafficking During <i>Eimeria bovis</i> Macromeront Formation.

The Compound U18666A Inhibits the Intoxication of Cells by <i>Clostridioides difficile</i> Toxins TcdA and TcdB.

Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology.

The Antihypertensive Drug Telmisartan Protects Oligodendrocytes from Cholesterol Accumulation and Promotes Differentiation by a PPAR-γ-Mediated Mechanism.

Suppression of neuronal cholesterol biosynthesis impairs brain functions through insulin-like growth factor I-Akt signaling.

Reversal of apolipoprotein E4-dependent or chemical-induced accumulation of APP degradation products by vitamin C-induced release of heparan sulfate from glypican-1.

Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation.

NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry.

Phagocytic and pinocytic uptake of cholesterol in Tetrahymena thermophila impact differently on gene regulation for sterol homeostasis.

Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms.

In Vivo Antiviral Effects of U18666A Against Type I Feline Infectious Peritonitis Virus.

U18666A inhibits classical swine fever virus replication through interference with intracellular cholesterol trafficking.

Bafilomycin A1 and U18666A Efficiently Impair ZIKV Infection.

Endosomal-Lysosomal Cholesterol Sequestration by U18666A Differentially Regulates Amyloid Precursor Protein (APP) Metabolism in Normal and APP-Overexpressing Cells.

Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors.

The cholesterol transport inhibitor U18666A inhibits type I feline coronavirus infection.

Effects of cholesterol transport inhibitor U18666A on APP metabolism in rat primary astrocytes.

U18666A, an activator of sterol regulatory element binding protein pathway, modulates presynaptic dopaminergic phenotype of SH-SY5Y neuroblastoma cells.

The Intracellular Cholesterol Transport Inhibitor U18666A Inhibits the Exosome-Dependent Release of Mature Hepatitis C Virus.

Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly.

The mechanism of the effect of U18666a on blocking the activity of 3β-hydroxysterol Δ-24-reductase (DHCR24): molecular dynamics simulation study and free energy analysis.

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection.

U18666A Treatment Results in Cholesterol Accumulation, Reduced Na(+), K(+)-ATPase Activity, and Increased Oxidative Stress in Rat Cortical Astrocytes.

Protective Effect of DHT on Apoptosis Induced by U18666A via PI3K/Akt Signaling Pathway in C6 Glial Cell Lines.

Effect of u18666a on beta-glucosidase, sphingomyelinase, and beta-galactosidase activities in astrocytes of young rats.

Comparison of the anti-prion mechanism of four different anti-prion compounds, anti-PrP monoclonal antibody 44B1, pentosan polysulfate, chlorpromazine, and U18666A, in prion-infected mouse neuroblastoma cells.

Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.

U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication.