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Publikationer i urvalet

138 träffar

Bibliografisk träff 2007-12-05

Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine.

Li C, Prichard MN, Korba BE, Drach JC, Zemlicka J.

Bioorg Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2007.11.082

Bibliografisk träff 2007-10-26

Synthesis and evaluation of cis-1-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-5-[(124)I]iodouracil: a new potential PET imaging agent for HSV1-tk expression.

Ahn H, Choi TH, De Castro K, Lee KC, Kim B, Moon BS, Hong SH, Lee JC, Chun KS, Cheon GJ, Lim SM, An GI, Rhee H.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm070791g

Bibliografisk träff 2007-10-19

Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.

Krecmerová M, Holý A, Pohl R, Masojídková M, Andrei G, Naesens L, Neyts J, Balzarini J, De Clercq E, Snoeck R.

J Med Chem · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1021/jm0707166

Bibliografisk träff 2007-08-02

Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.

Gazivoda T, Sokcević M, Kralj M, Suman L, Pavelić K, De Clercq E, Andrei G, Snoeck R, Balzarini J, Mintas M, Raić-Malić S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm070324z

Bibliografisk träff 2007-07-10

Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.

Robins MJ, Nowak I, Rajwanshi VK, Miranda K, Cannon JF, Peterson MA, Andrei G, Snoeck R, De Clercq E, Balzarini J.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm070210n

Bibliografisk träff 2007-06-01

Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.

Prekupec S, Makuc D, Plavec J, Suman L, Kralj M, Pavelić K, Balzarini J, Clercq ED, Mintas M, Raić-Malić S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0614329

Bibliografisk träff 2007-05-23

5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.

Cristofoli WA, Wiebe LI, De Clercq E, Andrei G, Snoeck R, Balzarini J, Knaus EE.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0701472

Bibliografisk träff 2007-05-10

7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase.

Larsen SD, Zhang Z, DiPaolo BA, Manninen PR, Rohrer DC, Hageman MJ, Hopkins TA, Knechtel ML, Oien NL, Rush BD, Schwende FJ, Stefanski KJ, Wieber JL, Wilkinson KF, Zamora KM, Wathen MW, Brideau RJ.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2007.05.010

Bibliografisk träff 2007-04-16

Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.

Focher F, Lossani A, Verri A, Spadari S, Maioli A, Gambino JJ, Wright GE, Eberle R, Black DH, Medveczky P, Medveczky M, Shugar D.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.01284-06

Bibliografisk träff 2007-04-05

2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases.

Schnute ME, Anderson DJ, Brideau RJ, Ciske FL, Collier SA, Cudahy MM, Eggen M, Genin MJ, Hopkins TA, Judge TM, Kim EJ, Knechtel ML, Nair SK, Nieman JA, Oien NL, Scott A, Tanis SP, Vaillancourt VA, Wathen MW, Wieber JL.

Bioorg Med Chem Lett · comparative study; journal article · DOI 10.1016/j.bmcl.2007.03.102

Bibliografisk träff 2007-04-03

9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.

Ohtawa M, Ichikawa S, Teishikata Y, Fujimuro M, Yokosawa H, Matsuda A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm070032y

Bibliografisk träff 2007-03-24

Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV).

Véron JB, Enguehard-Gueiffier C, Snoeck R, Andrei G, De Clercq E, Gueiffier A.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.03.061

Bibliografisk träff 2007-02-14

Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.

Krecmerová M, Holý A, Pískala A, Masojídková M, Andrei G, Naesens L, Neyts J, Balzarini J, De Clercq E, Snoeck R.

J Med Chem · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1021/jm061281+

Bibliografisk träff 2007-02-08

SAR studies on a novel series of human cytomegalovirus primase inhibitors.

Chen X, Adrian J, Cushing T, Dimaio H, Liang L, Mayorga V, Miao S, Peterson MG, Powers JP, Spector F, Stein C, Wright M, Xu D, Ye Q, Jaen J.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2007.01.109

Bibliografisk träff 2007-01-04

Antiviral activity of berberine and related compounds against human cytomegalovirus.

Hayashi K, Minoda K, Nagaoka Y, Hayashi T, Uesato S.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2006.12.085

Bibliografisk träff 2006-12-01

N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.

Hernandez AI, Familiar O, Negri A, Rodríguez-Barrios F, Gago F, Karlsson A, Camarasa MJ, Balzarini J, Pérez-Pérez MJ.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0610550

Bibliografisk träff 2006-12-01

Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.

Barral K, Priet S, Sire J, Neyts J, Balzarini J, Canard B, Alvarez K.

J Med Chem · research support, non-u.s. gov't; evaluation study; journal article · DOI 10.1021/jm060030y

Bibliografisk träff 2006-11-18

Synthesis and antiviral activity of C-fluoro-branched cyclopropyl nucleosides.

Kim A, Hong JH.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2006.11.002

Bibliografisk träff 2006-11-10

Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir.

Eriksson U, Hilfinger JM, Kim JS, Mitchell S, Kijek P, Borysko KZ, Breitenbach JM, Drach JC, Kashemirov BA, McKenna CE.

Bioorg Med Chem Lett · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2006.11.012

Bibliografisk träff 2006-10-25

The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.

Gazivoda T, Raić-Malić S, Marjanović M, Kralj M, Pavelić K, Balzarini J, De Clercq E, Mintas M.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2006.10.046

Bibliografisk träff 2006-10-16

Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates.

Scott GM, Weinberg A, Rawlinson WD, Chou S.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.00633-06

Bibliografisk träff 2006-10-01

9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.

Zhou S, Kern ER, Gullen E, Cheng YC, Drach JC, Tamiya S, Mitsuya H, Zemlicka J.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm0607404

Bibliografisk träff 2006-06-30

Discovery of a novel series of inhibitors of human cytomegalovirus primase.

Cushing TD, Adrian J, Chen X, DiMaio H, Doughan B, Flygare J, Liang L, Mayorga V, Miao S, Mellon H, Peterson MG, Powers JP, Spector F, Stein C, Wright M, Xu D, Ye Q, Jaen J.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2006.06.066

Bibliografisk träff 2006-06-01

Effect of various pyrimidines possessing the 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl] moiety, able to mimic natural 2'-deoxyribose, on wild-type and mutant hepatitis B virus replication.

Kumar R, Semaine W, Johar M, Tyrrell DL, Agrawal B.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm060102l

Bibliografisk träff 2006-02-01

Inactivation of S-adenosyl-L-homocysteine hydrolase by 6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine and 6'-chloro-6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine. Antiviral and cytotoxic effects.

Guillerm G, Muzard M, Glapski C, Pilard S, De Clercq E.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm051023x

Bibliografisk träff 2006-01-01

Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives.

Barral K, Balzarini J, Neyts J, De Clercq E, Hider RC, Camplo M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0504306

Bibliografisk träff 2006-01-01

Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives.

Robins MJ, Miranda K, Rajwanshi VK, Peterson MA, Andrei G, Snoeck R, De Clercq E, Balzarini J.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm050867d

Bibliografisk träff 2006-01-01

Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.

Rescifina A, Chiacchio MA, Corsaro A, De Clercq E, Iannazzo D, Mastino A, Piperno A, Romeo G, Romeo R, Valveri V.

J Med Chem · journal article · DOI 10.1021/jm050772b

Bibliografisk träff 2005-09-01

4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as non-nucleoside inhibitors of human cytomegalovirus and related herpesvirus polymerases.

Schnute ME, Cudahy MM, Brideau RJ, Homa FL, Hopkins TA, Knechtel ML, Oien NL, Pitts TW, Poorman RA, Wathen MW, Wieber JL.

J Med Chem · journal article · DOI 10.1021/jm050162b

Bibliografisk träff 2005-04-01

From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors.

Gerona-Navarro G, Pérez de Vega MJ, García-López MT, Andrei G, Snoeck R, De Clercq E, Balzarini J, González-Muñiz R.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0492812