Cyclosporine A- and tacrolimus-mediated inhibition of CYP3A4 and CYP3A5 in vitro.
Amundsen R, Åsberg A, Ohm IK, Christensen H.
Drug Metab Dispos · journal article · DOI 10.1124/dmd.111.043018 PUBLIKATIONSREGISTRET
Gå till forskningen.
Publikationsdata från Europe PMC och PubMed. Följ källhänvisningar från ämnesregistret till originalpublikationerna.
Publikationer som ChEBI hänvisar till för tacrolimus anhydrous. Visa hela publikationsregistret
En publikationsträff är inte en slutsats. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.
Publikationer i urvalet
50 träffarTranslating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.
PLoS Comput Biol · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1371/journal.pcbi.1002310FDA-approved drug labeling for the study of drug-induced liver injury.
Chen M, Vijay V, Shi Q, Liu Z, Fang H, Tong W.
Drug Discov Today · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/j.drudis.2011.05.007In vitro investigation of human UDP-glucuronosyltransferase isoforms responsible for tacrolimus glucuronidation: predominant contribution of UGT1A4.
Laverdière I, Caron P, Harvey M, Lévesque É, Guillemette C.
Drug Metab Dispos · research support, non-u.s. gov't; journal article · DOI 10.1124/dmd.111.039040Oroidin inhibits the activity of the multidrug resistance target Pdr5p from yeast plasma membranes.
da Silva FR, Tessis AC, Ferreira PF, Rangel LP, Garcia-Gomes AS, Pereira FR, Berlinck RG, Muricy G, Ferreira-Pereira A.
J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/np1006247Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Lin X, Skolnik S, Chen X, Wang J.
Drug Metab Dispos · journal article · DOI 10.1124/dmd.110.034629Identification of clinically used drugs that activate pregnane X receptors.
Shukla SJ, Sakamuru S, Huang R, Moeller TA, Shinn P, Vanleer D, Auld DS, Austin CP, Xia M.
Drug Metab Dispos · research support, n.i.h., intramural; research-article; journal article · DOI 10.1124/dmd.110.035105Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Varma MV, Obach RS, Rotter C, Miller HR, Chang G, Steyn SJ, El-Kattan A, Troutman MD.
J Med Chem · journal article · DOI 10.1021/jm901371vCheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Fourches D, Barnes JC, Day NC, Bradley P, Reed JZ, Tropsha A.
Chem Res Toxicol · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/tx900326kPhysicochemical determinants of human renal clearance.
Varma MV, Feng B, Obach RS, Troutman MD, Chupka J, Miller HR, El-Kattan A.
J Med Chem · journal article · DOI 10.1021/jm900403jIn vitro interactions between antifungals and immunosuppressive drugs against zygomycetes.
Dannaoui E, Schwarz P, Lortholary O.
Antimicrob Agents Chemother · research-article; journal article · DOI 10.1128/aac.00184-09Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus.
Fortwendel JR, Juvvadi PR, Pinchai N, Perfect BZ, Alspaugh JA, Perfect JR, Steinbach WJ.
Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.01154-08Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei.
Lamping E, Ranchod A, Nakamura K, Tyndall JD, Niimi K, Holmes AR, Niimi M, Cannon RD.
Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.01095-08Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Obach RS, Lombardo F, Waters NJ.
Drug Metab Dispos · journal article · DOI 10.1124/dmd.108.020479Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors.
Stebbins JL, Zhang Z, Chen J, Wu B, Emdadi A, Williams ME, Cashman J, Pellecchia M.
J Med Chem · journal article; research support, n.i.h., extramural · DOI 10.1021/jm0707424Effect of calcineurin inhibitors on posaconazole blood levels as measured by the MVista microbiological assay.
Zhuang D, Smedema M, Lemonte A, Book BK, Pescovitz MD, Wheat LJ.
Antimicrob Agents Chemother · research-article; journal article · DOI 10.1128/aac.01096-07Hologram QSAR model for the prediction of human oral bioavailability.
Moda TL, Montanari CA, Andricopulo AD.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.08.060Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.
Onyewu C, Eads E, Schell WA, Perfect JR, Ullmann Y, Kaufman G, Horwitz BA, Berdicevsky I, Heitman J.
Antimicrob Agents Chemother · comparative study; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.00492-07Splicing factor SF3b as a target of the antitumor natural product pladienolide.
Kotake Y, Sagane K, Owa T, Mimori-Kiyosue Y, Shimizu H, Uesugi M, Ishihama Y, Iwata M, Mizui Y.
Nat Chem Biol · journal article · DOI 10.1038/nchembio.2007.16Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.
Steinbach WJ, Cramer RA, Perfect BZ, Henn C, Nielsen K, Heitman J, Perfect JR.
Antimicrob Agents Chemother · research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.01394-06Vialinin B, a novel potent inhibitor of TNF-alpha production, isolated from an edible mushroom, Thelephora vialis.
Xie C, Koshino H, Esumi Y, Onose J, Yoshikawa K, Abe N.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2006.07.068FK506-binding protein ligands: structure-based design, synthesis, and neurotrophic/neuroprotective properties of substituted 5,5-dimethyl-2-(4-thiazolidine)carboxylates.
Zhao L, Huang W, Liu H, Wang L, Zhong W, Xiao J, Hu Y, Li S.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0502384Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
Wang YH, Li Y, Li YH, Yang SL, Yang L.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2005.06.015UDP-glucuronosyltransferases and clinical drug-drug interactions.
Kiang TK, Ensom MH, Chang TK.
Pharmacol Ther · research support, non-u.s. gov't; review; journal article · DOI 10.1016/j.pharmthera.2004.10.013A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.
Hersperger R, Buchheit KH, Cammisuli S, Enz A, Lohse O, Ponelle M, Schuler W, Schweitzer A, Walker C, Zehender H, Zenke G, Zimmerlin AG, Zollinger M, Mazzoni L, Fozard JR.
J Med Chem · journal article · DOI 10.1021/jm031101l[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].
Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.
Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo.
Collett A, Tanianis-Hughes J, Hallifax D, Warhurst G.
Pharm Res · journal article · DOI 10.1023/b:pham.0000026434.82855.69Immunomodulatory constituents from an Ascomycete, Chaetomium seminudum.
Fujimoto H, Sumino M, Okuyama E, Ishibashi M.
J Nat Prod · journal article · DOI 10.1021/np0302201Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins.
Fehrenbach T, Cui Y, Faulstich H, Keppler D.
Naunyn Schmiedebergs Arch Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1007/s00210-003-0814-4SMall Molecule Growth 2001 (SMoG2001): an improved knowledge-based scoring function for protein-ligand interactions.
Ishchenko AV, Shakhnovich EI.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm0105833