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Publikationer i urvalet

50 träffar

Bibliografisk träff 2017-05-17

One-pot microwave assisted stereoselective synthesis of novel dihydro-2'H-spiro[indene-2,1'-pyrrolo-[3,4-c]pyrrole]-tetraones and evaluation of their antimycobacterial activity and inhibition of AChE.

Bharkavi C, Vivek Kumar S, Ashraf Ali M, Osman H, Muthusubramanian S, Perumal S.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2017.05.050

Bibliografisk träff 2017-03-15

Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci.

Mohammad H, Younis W, Chen L, Peters CE, Pogliano J, Pogliano K, Cooper B, Zhang J, Mayhoub A, Oldfield E, Cushman M, Seleem MN.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.6b01780

Bibliografisk träff 2016-12-31

Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis.

Vajs J, Proud C, Brozovic A, Gazvoda M, Lloyd A, Roper DI, Osmak M, Košmrlj J, Dowson CG.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.12.060

Bibliografisk träff 2016-09-19

A facile stereoselective synthesis of dispiro-indeno pyrrolidine/pyrrolothiazole-thiochroman hybrids and evaluation of their antimycobacterial, anticancer and AchE inhibitory activities.

Bharkavi C, Vivek Kumar S, Ashraf Ali M, Osman H, Muthusubramanian S, Perumal S.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2016.09.044

Bibliografisk träff 2016-07-21

Synthesis and biological activity of furoxan derivatives against Mycobacterium tuberculosis.

Fernandes GFDS, de Souza PC, Marino LB, Chegaev K, Guglielmo S, Lazzarato L, Fruttero R, Chung MC, Pavan FR, Dos Santos JL.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.07.039

Bibliografisk träff 2016-03-18

Design and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosis.

Santivañez-Veliz M, Pérez-Silanes S, Torres E, Moreno-Viguri E.

Bioorg Med Chem Lett · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2016.03.066

Bibliografisk träff 2016-03-03

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.

Drug Discov Today · review; journal article · DOI 10.1016/j.drudis.2016.02.015

Bibliografisk träff 2014-08-05

Sequential synthesis of amino-1,4-naphthoquinone-appended triazoles and triazole-chromene hybrids and their antimycobacterial evaluation.

Devi Bala B, Muthusaravanan S, Choon TS, Ashraf Ali M, Perumal S.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2014.08.009

Bibliografisk träff 2014-06-27

Design and synthesis of 3-isoxazolidone derivatives as new Chlamydia trachomatis inhibitors.

Abdelsayed S, Ha Duong NT, Hai J, Hémadi M, El Hage Chahine JM, Verbeke P, Serradji N.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2014.06.056

Bibliografisk träff 2014-01-11

Antimycobacterial evaluation of novel hybrid arylidene thiazolidine-2,4-diones.

Ponnuchamy S, Kanchithalaivan S, Ranjith Kumar R, Ali MA, Choon TS.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2014.01.007

Bibliografisk träff 2013-12-25

Design, synthesis and evaluation of acridine and fused-quinoline derivatives as potential anti-tuberculosis agents.

Muscia GC, Buldain GY, Asís SE.

Eur J Med Chem · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ejmech.2013.12.013

Bibliografisk träff 2013-11-07

Antimycobacterial activity of nitrogen heterocycles derivatives: bipyridine derivatives. Part III.

Danac R, Mangalagiu II.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2013.09.061

Bibliografisk träff 2013-10-05

Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in <i>Mycobacterium tuberculosis.</i>

Prosser GA, de Carvalho LP.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml400349n

Bibliografisk träff 2013-10-02

Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.

Hwang CH, Jaki BU, Klein LL, Lankin DC, McAlpine JB, Napolitano JG, Fryling NA, Franzblau SG, Cho SH, Stamets PE, Wang Y, Pauli GF.

J Nat Prod · research-article; journal article · DOI 10.1021/np400497f

Bibliografisk träff 2013-01-04

A facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines acting as antimycobacterial agents.

Wei AC, Ali MA, Yoon YK, Ismail R, Choon TS, Kumar RS.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2012.12.069

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2012-05-15

Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2'-'up' fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors.

Shakya N, Srivastav NC, Bhavanam S, Tse C, Desroches N, Agrawal B, Kunimoto DY, Kumar R.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2012.05.004

Bibliografisk träff 2011-12-15

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.

PLoS Comput Biol · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1371/journal.pcbi.1002310

Bibliografisk träff 2011-12-04

Antimycobacterial activities of 5-alkyl (or halo)-3'-substituted pyrimidine nucleoside analogs.

Srivastav NC, Shakya N, Bhavanam S, Agrawal A, Tse C, Desroches N, Kunimoto DY, Kumar R.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2011.11.114

Bibliografisk träff 2011-09-30

In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.

Dawson S, Stahl S, Paul N, Barber J, Kenna JG.

Drug Metab Dispos · comparative study; journal article · DOI 10.1124/dmd.111.040758

Bibliografisk träff 2011-09-05

Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).

Thondorf I, Voigt V, Schäfer S, Gebauer S, Zebisch K, Laug L, Brandsch M.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2011.08.058

Bibliografisk träff 2010-11-09

Prediction of drug intestinal absorption by new linear and non-linear QSPR.

Talevi A, Goodarzi M, Ortiz EV, Duchowicz PR, Bellera CL, Pesce G, Castro EA, Bruno-Blanch LE.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2010.11.005

Bibliografisk träff 2010-08-16

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

Khanna A, Raj VS, Tarai B, Sood R, Pareek PK, Upadhyay DJ, Sharma P, Rattan A, Saini KS, Singh H.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00661-10

Bibliografisk träff 2010-08-01

Inhibition of mycobacterial replication by pyrimidines possessing various C-5 functionalities and related 2'-deoxynucleoside analogues using in vitro and in vivo models.

Srivastav NC, Rai D, Tse C, Agrawal B, Kunimoto DY, Kumar R.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm100568q

Bibliografisk träff 2010-05-01

3'-bromo analogues of pyrimidine nucleosides as a new class of potent inhibitors of Mycobacterium tuberculosis.

Shakya N, Srivastav NC, Desroches N, Agrawal B, Kunimoto DY, Kumar R.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm100165w

Bibliografisk träff 2009-12-21

Neural computational prediction of oral drug absorption based on CODES 2D descriptors.

Guerra A, Campillo NE, Páez JA.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2009.11.034

Bibliografisk träff 2009-09-27

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting.

Pathania R, Zlitni S, Barker C, Das R, Gerritsma DA, Lebert J, Awuah E, Melacini G, Capretta FA, Brown ED.

Nat Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1038/nchembio.221

Bibliografisk träff 2009-08-01

Drug design, in vitro pharmacology, and structure-activity relationships of 3-acylamino-2-aminopropionic acid derivatives, a novel class of partial agonists at the glycine site on the N-methyl-D-aspartate (NMDA) receptor complex.

Urwyler S, Floersheim P, Roy BL, Koller M.

J Med Chem · journal article · DOI 10.1021/jm900363q

Bibliografisk träff 2009-06-22

Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model.

Kurokawa K, Hamamoto H, Matsuo M, Nishida S, Yamane N, Lee BL, Murakami K, Maki H, Sekimizu K.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00200-09

Bibliografisk träff 2009-05-26

MurF inhibitors with antibacterial activity: effect on muropeptide levels.

Baum EZ, Crespo-Carbone SM, Foleno BD, Simon LD, Guillemont J, Macielag M, Bush K.

Antimicrob Agents Chemother · research-article; journal article · DOI 10.1128/aac.00166-09