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Publikationer i urvalet

50 träffar

Bibliografisk träff 2018-08-01

Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases.

Gealageas R, Devineau A, So PPL, Kim CMJ, Surendradoss J, Buchwalder C, Heller M, Goebeler V, Dullaghan EM, Grierson DS, Putnins EE.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.7b01588

Bibliografisk träff 2018-02-16

Novel indanone derivatives as MAO B/H<sub>3</sub>R dual-targeting ligands for treatment of Parkinson's disease.

Affini A, Hagenow S, Zivkovic A, Marco-Contelles J, Stark H.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.02.015

Bibliografisk träff 2017-11-24

Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy.

Yeon SK, Choi JW, Park JH, Lee YR, Kim HJ, Shin SJ, Jang BK, Kim S, Bahn YS, Han G, Lee YS, Pae AN, Park KD.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2017.11.036

Bibliografisk träff 2017-08-10

Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?

Fonseca A, Reis J, Silva T, Matos MJ, Bagetta D, Ortuso F, Alcaro S, Uriarte E, Borges F.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.7b00918

Bibliografisk träff 2017-04-22

The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase.

Mostert S, Petzer A, Petzer JP.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.04.055

Bibliografisk träff 2017-03-01

Discovery of highly selective and potent monoamine oxidase B inhibitors: Contribution of additional phenyl rings introduced into 2-aryl-1,3,4-oxadiazin-5(6H)-one.

Lee J, Lee Y, Park SJ, Lee J, Kim YS, Suh YG, Lee J.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.02.059

Bibliografisk träff 2016-06-10

Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors.

Reis J, Cagide F, Chavarria D, Silva T, Fernandes C, Gaspar A, Uriarte E, Remião F, Alcaro S, Ortuso F, Borges F.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.6b00527

Bibliografisk träff 2016-03-16

An evaluation of synthetic indole derivatives as inhibitors of monoamine oxidase.

Chirkova ZV, Kabanova MV, Filimonov SI, Abramov IG, Petzer A, Petzer JP, Suponitsky KY.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2016.03.060

Bibliografisk träff 2016-01-16

Inhibition of monoamine oxidase by benzoxathiolone analogues.

Mostert S, Petzer A, Petzer JP.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2016.01.034

Bibliografisk träff 2015-08-19

Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors.

Choi JW, Jang BK, Cho NC, Park JH, Yeon SK, Ju EJ, Lee YS, Han G, Pae AN, Kim DJ, Park KD.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2015.08.012

Bibliografisk träff 2015-04-11

Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.

Torregrosa R, Yang XF, Dustrude ET, Cummins TR, Khanna R, Kohn H.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2015.04.014

Bibliografisk träff 2015-01-03

Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.

Rojas RJ, Edmondson DE, Almos T, Scott R, Massari ME.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2014.12.063

Bibliografisk träff 2014-07-16

Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency.

Tzvetkov NT, Hinz S, Küppers P, Gastreich M, Müller CE.

J Med Chem · journal article · DOI 10.1021/jm500729a

Bibliografisk träff 2014-02-08

Alkynyl-coumarinyl ethers as MAO-B inhibitors.

Mertens MD, Hinz S, Müller CE, Gütschow M.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2014.01.046

Bibliografisk träff 2013-09-25

1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.

Koch P, Akkari R, Brunschweiger A, Borrmann T, Schlenk M, Küppers P, Köse M, Radjainia H, Hockemeyer J, Drabczyńska A, Kieć-Kononowicz K, Müller CE.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2013.09.044

Bibliografisk träff 2013-05-30

Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.

Stössel A, Schlenk M, Hinz S, Küppers P, Heer J, Gütschow M, Müller CE.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm400336x

Bibliografisk träff 2010-05-01

Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities.

Salomé C, Salomé-Grosjean E, Stables JP, Kohn H.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm100185c

Bibliografisk träff 2009-03-11

Knowledge based identification of MAO-B selective inhibitors using pharmacophore and structure based virtual screening models.

Boppana K, Dubey PK, Jagarlapudi SA, Vadivelan S, Rambabu G.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2009.02.031

Bibliografisk träff 2007-10-04

Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs.

Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A.

J Med Chem · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1021/jm070677y

Bibliografisk träff 2007-09-07

Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.

Leonetti F, Capaldi C, Pisani L, Nicolotti O, Muncipinto G, Stefanachi A, Cellamare S, Caccia C, Carotti A.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm070725e