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Publikationer i urvalet

50 träffar

Bibliografisk träff 2011-08-04

2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): a potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A.

Nishio Y, Kimura H, Sawada N, Sugaru E, Horiguchi M, Ono M, Furuta Y, Sakai M, Masui Y, Otani M, Hashizuka T, Honda Y, Deguchi J, Nakagawa T, Nakahira H.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2011.07.042

Bibliografisk träff 2011-08-02

Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?

Van Goethem S, Matheeussen V, Matheeussen V, Joossens J, Lambeir AM, Chen X, De Meester I, Haemers A, Augustyns K, Van der Veken P.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm200383j

Bibliografisk träff 2010-09-01

Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein.

Tsai TY, Yeh TK, Chen X, Hsu T, Jao YC, Huang CH, Song JS, Huang YC, Chien CH, Chiu JH, Yen SC, Tang HK, Chao YS, Jiaang WT.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm1002556

Bibliografisk träff 2010-05-18

Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes.

Cho TP, Long YF, Gang LZ, Yang W, Jun LH, Yuan SG, Hong FJ, Lin W, Liang GD, Lei Z, Jing LJ, Shen GA, Hong SG, Dan W, Ying F, Ke YP, Ying L, Jun F, Tai MX.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2010.04.120

Bibliografisk träff 2010-05-18

Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes.

Cho TP, Gang LZ, Long YF, Yang W, Qian W, Lei Z, Jing LJ, Ying F, Ke YP, Ying L, Jun F.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2010.04.138

Bibliografisk träff 2010-05-17

(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

Yeh TK, Tsai TY, Hsu T, Cheng JH, Chen X, Song JS, Shy HS, Chiou MC, Chien CH, Tseng YJ, Huang CY, Yeh KC, Huang YL, Huang CH, Huang YW, Wang MH, Tang HK, Chao YS, Chen CT, Jiaang WT.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2010.04.124

Bibliografisk träff 2009-07-01

In silico prediction of volume of distribution in human using linear and nonlinear models on a 669 compound data set.

Berellini G, Springer C, Waters NJ, Lombardo F.

J Med Chem · journal article · DOI 10.1021/jm9004658

Bibliografisk träff 2009-05-18

Bicyclic cyanothiazolidines as novel dipeptidyl peptidase 4 inhibitors.

Betancort JM, Winn DT, Liu R, Xu Q, Liu J, Liao W, Chen SH, Carney D, Hanway D, Schmeits J, Li X, Gordon E, Campbell DA.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.05.048

Bibliografisk träff 2009-03-26

Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors.

Wang L, Zhang B, Ji J, Li B, Yan J, Zhang W, Wu Y, Wang X.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2009.03.021

Bibliografisk träff 2009-02-21

Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors.

Tsai TY, Hsu T, Chen CT, Cheng JH, Chiou MC, Huang CH, Tseng YJ, Yeh TK, Huang CY, Yeh KC, Huang YW, Wu SH, Wang MH, Chen X, Chao YS, Jiaang WT.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2009.02.061

Bibliografisk träff 2009-02-20

Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors.

Tsai TY, Hsu T, Chen CT, Cheng JH, Yeh TK, Chen X, Huang CY, Chang CN, Yeh KC, Hsieh SH, Chien CH, Chang YW, Huang CH, Huang YW, Huang CL, Wu SH, Wang MH, Lu CT, Chao YS, Jiaang WT.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2009.02.020

Bibliografisk träff 2009-01-31

Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes.

Havale SH, Pal M.

Bioorg Med Chem · review; journal article · DOI 10.1016/j.bmc.2009.01.061

Bibliografisk träff 2008-07-02

Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors.

Sattigeri JA, Andappan MM, Kishore K, Thangathirupathy S, Sundaram S, Singh S, Sharma S, Davis JA, Chugh A, Bansal VS.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.05.101

Bibliografisk träff 2008-05-24

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads.

Van der Veken P, De Meester I, Dubois V, Soroka A, Van Goethem S, Maes MB, Brandt I, Lambeir AM, Chen X, Haemers A, Scharpé S, Augustyns K.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2008.05.080

Bibliografisk träff 2006-10-01

Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.

Madar DJ, Kopecka H, Pireh D, Yong H, Pei Z, Li X, Wiedeman PE, Djuric SW, Von Geldern TW, Fickes MG, Bhagavatula L, McDermott T, Wittenberger S, Richards SJ, Longenecker KL, Stewart KD, Lubben TH, Ballaron SJ, Stashko MA, Long MA, Wells H, Zinker BA, Mika AK, Beno DW, Kempf-Grote AJ, Polakowski J, Segreti J, Reinhart GA, Fryer RM, Sham HL, Trevillyan JM.

J Med Chem · journal article · DOI 10.1021/jm060777o

Bibliografisk träff 2006-01-01

2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

Tsu H, Chen X, Chen CT, Lee SJ, Chang CN, Kao KH, Coumar MS, Yeh YT, Chien CH, Wang HS, Lin KT, Chang YY, Wu SH, Chen YS, Lu IL, Wu SY, Tsai TY, Chen WC, Hsieh HP, Chao YS, Jiaang WT.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0507781

Bibliografisk träff 2005-07-01

Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors.

Lu IL, Lee SJ, Tsu H, Wu SY, Kao KH, Chien CH, Chang YY, Chen YS, Cheng JH, Chang CN, Chen TW, Chang SP, Chen X, Jiaang WT.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2005.04.051

Bibliografisk träff 2005-02-01

Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8.

Jiaang WT, Chen YS, Hsu T, Wu SH, Chien CH, Chang CN, Chang SP, Lee SJ, Chen X.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2004.11.023

Bibliografisk träff 2004-08-01

Dipeptidyl peptidase IV inhibitors for the treatment of diabetes.

Weber AE.

J Med Chem · review; journal article · DOI 10.1021/jm030628v

Bibliografisk träff 2004-01-01

4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors.

Parmee ER, He J, Mastracchio A, Edmondson SD, Colwell L, Eiermann G, Feeney WP, Habulihaz B, He H, Kilburn R, Leiting B, Lyons K, Marsilio F, Patel RA, Petrov A, Di Salvo J, Wu JK, Thornberry NA, Weber AE.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2003.10.016