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Publikationer i urvalet

50 träffar

Bibliografisk träff 1999-12-01

Synthesis and biological evaluation of dihydrobenzofuran lignans and related compounds as potential antitumor agents that inhibit tubulin polymerization.

Pieters L, Van Dyck S, Gao M, Bai R, Hamel E, Vlietinck A, Lemière G.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm990251m

Bibliografisk träff 1999-10-01

Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

Zhang SX, Bastow KF, Tachibana Y, Kuo SC, Hamel E, Mauger A, Narayanan VL, Lee KH.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm990208z

Bibliografisk träff 1999-04-01

Antineoplastic agents. 410. Asymmetric hydroxylation of trans-combretastatin A-4.

Pettit GR, Toki BE, Herald DL, Boyd MR, Hamel E, Pettit RK, Chapuis JC.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm9807149

Bibliografisk träff 1999-04-01

A new anti-tubulin agent containing the benzo[b]thiophene ring system.

Pinney KG, Bounds AD, Dingeman KM, Mocharla VP, Pettit GR, Bai R, Hamel E.

Bioorg Med Chem Lett · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(99)00143-2

Bibliografisk träff 1998-12-01

Novel B-ring modified combretastatin analogues: syntheses and antineoplastic activity.

Hatanaka T, Fujita K, Ohsumi K, Nakagawa R, Fukuda Y, Nihei Y, Suga Y, Akiyama Y, Tsuji T.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(98)00622-2

Bibliografisk träff 1998-08-01

Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.

Shirai R, Takayama H, Nishikawa A, Koiso Y, Hashimoto Y.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(98)00344-8

Bibliografisk träff 1998-07-01

Novel combretastatin analogues effective against murine solid tumors: design and structure-activity relationships.

Ohsumi K, Nakagawa R, Fukuda Y, Hatanaka T, Morinaga Y, Nihei Y, Ohishi K, Suga Y, Akiyama Y, Tsuji T.

J Med Chem · journal article · DOI 10.1021/jm980101w

Bibliografisk träff 1998-05-01

Antineoplastic agents. 379. Synthesis of phenstatin phosphate.

Pettit GR, Toki B, Herald DL, Verdier-Pinard P, Boyd MR, Hamel E, Pettit RK.

J Med Chem · comparative study; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm970644q

Bibliografisk träff 1998-03-01

Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.

Xia Y, Yang ZY, Xia P, Bastow KF, Tachibana Y, Kuo SC, Hamel E, Hackl T, Lee KH.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm9707479

Bibliografisk träff 1997-11-01

Isolation, synthesis, and antiplatelet aggregation activity of resveratrol 3-O-beta-D-glucopyranoside and related compounds.

Orsini F, Pelizzoni F, Verotta L, Aburjai T, Rogers CB.

J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/np970069t

Bibliografisk träff 1997-09-01

Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization.

Chen K, Kuo SC, Hsieh MC, Mauger A, Lin CM, Hamel E, Lee KH.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm970146h

Bibliografisk träff 1997-07-01

Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

Chen K, Kuo SC, Hsieh MC, Mauger A, Lin CM, Hamel E, Lee KH.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm960858s

Bibliografisk träff 1995-05-01

Antineoplastic agents. 291. Isolation and synthesis of combretastatins A-4, A-5, and A-6(1a)

Pettit GR, Singh SB, Boyd MR, Hamel E, Pettit RK, Schmidt JM, Hogan F.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00010a011

Bibliografisk träff 1994-09-01

Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.

Li L, Wang HK, Kuo SC, Wu TS, Mauger A, Lin CM, Hamel E, Lee KH.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00046a025

Bibliografisk träff 1994-04-01

Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

Li L, Wang HK, Kuo SC, Wu TS, Lednicer D, Lin CM, Hamel E, Lee KH.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00034a010

Bibliografisk träff 1993-04-01

Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin.

Kuo SC, Lee HZ, Juang JP, Lin YT, Wu TS, Chang JJ, Lednicer D, Paull KD, Lin CM, Hamel E.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00061a005

Bibliografisk träff 1993-03-01

Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.

Sun L, McPhail AT, Hamel E, Lin CM, Hastie SB, Chang JJ, Lee KH.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00057a004

Bibliografisk träff 1992-06-01

Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents.

Cushman M, Nagarathnam D, Gopal D, He HM, Lin CM, Hamel E.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00090a021

Bibliografisk träff 1992-03-01

Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.

Getahun Z, Jurd L, Chu PS, Lin CM, Hamel E.

J Med Chem · journal article · DOI 10.1021/jm00084a011

Bibliografisk träff 1991-08-01

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.

Cushman M, Nagarathnam D, Gopal D, Chakraborti AK, Lin CM, Hamel E.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00112a036