Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes.
Cenedella RJ.
Lipids · review; journal article; research support, n.i.h., extramural · DOI 10.1007/s11745-009-3305-7 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
37 träffarNovel mechanism of U18666A-induced tumour necrosis factor-alpha production in RAW 264.7 macrophage cells.
Iftakhar-E-Khuda I, Koide N, Hassan F, Noman AS, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T.
Clin Exp Immunol · research support, non-u.s. gov't; journal article · DOI 10.1111/j.1365-2249.2008.03779.xHuman pregnane X receptor activation and CYP3A4/CYP2B6 induction by 2,3-oxidosqualene:lanosterol cyclase inhibition.
Duniec-Dmuchowski Z, Fang HL, Strom SC, Ellis E, Runge-Morris M, Kocarek TA.
Drug Metab Dispos · research-article; journal article; research support, n.i.h., extramural · DOI 10.1124/dmd.108.025130The cholesterol transport inhibitor U18666a regulates amyloid precursor protein metabolism and trafficking in N2aAPP "Swedish" cells.
Davis W.
Curr Alzheimer Res · journal article; research support, n.i.h., extramural · DOI 10.2174/156720508785908900Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons.
Koh CH, Whiteman M, Li QX, Halliwell B, Jenner AM, Wong BS, Laughton KM, Wenk M, Masters CL, Beart PM, Bernard O, Cheung NS.
J Neurochem · research support, non-u.s. gov't; journal article · DOI 10.1111/j.1471-4159.2006.03958.xComparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis.
Cenedella RJ, Sexton PS, Krishnan K, Covey DF.
Lipids · comparative study; research support, u.s. gov't, p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1007/s11745-005-1426-9Accumulation of tyrosinase in the endolysosomal compartment is induced by U18666A.
Hall AM, Krishnamoorthy L, Orlow SJ.
Pigment Cell Res · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1034/j.1600-0749.2003.00027.x