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Publikationer i urvalet

39 träffar

Bibliografisk träff 2017-11-04

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

Shadrick WR, Slavish PJ, Chai SC, Waddell B, Connelly M, Low JA, Tallant C, Young BM, Bharatham N, Knapp S, Boyd VA, Morfouace M, Roussel MF, Chen T, Lee RE, Kiplin Guy R, Shelat AA, Potter PM.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2017.10.042

Bibliografisk träff 2017-07-21

Structure-based design, synthesis and in vitro antiproliferative effects studies of novel dual BRD4/HDAC inhibitors.

Shao M, He L, Zheng L, Huang L, Zhou Y, Wang T, Chen Y, Shen M, Wang F, Yang Z, Chen L.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2017.07.054

Bibliografisk träff 2017-03-02

Drug Discovery Targeting Bromodomain-Containing Protein 4.

Liu Z, Wang P, Chen H, Wold EA, Tian B, Brasier AR, Zhou J.

J Med Chem · review-article; review; journal article · DOI 10.1021/acs.jmedchem.6b01761

Bibliografisk träff 2016-05-27

Development of 4,5-dihydro-benzodiazepinone derivatives as a new chemical series of BRD4 inhibitors.

Li J, Wang P, Zhou B, Shi J, Liu J, Li X, Fan L, Zheng Y, Ouyang L.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.05.057

Bibliografisk träff 2016-01-12

Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation.

Xue X, Zhang Y, Liu Z, Song M, Xing Y, Xiang Q, Wang Z, Tu Z, Zhou Y, Ding K, Xu Y.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.5b01511

Bibliografisk träff 2015-12-01

Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors.

Romero FA, Taylor AM, Crawford TD, Tsui V, Côté A, Magnuson S.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.5b01514

Bibliografisk träff 2015-10-01

New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition.

Baud MG, Lin-Shiao E, Zengerle M, Tallant C, Ciulli A.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.5b01135

Bibliografisk träff 2015-01-28

Discovery and structure-activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors.

Noguchi-Yachide T, Sakai T, Hashimoto Y, Yamaguchi T.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2015.01.022

Bibliografisk träff 2013-04-10

In vitro biosynthesis, isolation, and identification of predominant metabolites of 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (RVX-208).

Khmelnitsky YL, Mozhaev VV, Cotterill IC, Michels PC, Boudjabi S, Khlebnikov V, Madhava Reddy M, Wagner GS, Hansen HC.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2013.03.062