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Publikationer i urvalet

51 träffar

Bibliografisk träff 2008-02-13

Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists.

Cosimelli B, Greco G, Ehlardo M, Novellino E, Da Settimo F, Taliani S, La Motta C, Bellandi M, Tuccinardi T, Martinelli A, Ciampi O, Trincavelli ML, Martini C.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm701159t

Bibliografisk träff 2008-01-19

Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists.

Jeong LS, Lee HW, Kim HO, Tosh DK, Pal S, Choi WJ, Gao ZG, Patel AR, Williams W, Jacobson KA, Kim HD.

Bioorg Med Chem Lett · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.bmcl.2008.01.070

Bibliografisk träff 2007-10-10

5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.

Da Settimo F, Primofiore G, Taliani S, Marini AM, La Motta C, Simorini F, Salerno S, Sergianni V, Tuccinardi T, Martinelli A, Cosimelli B, Greco G, Novellino E, Ciampi O, Trincavelli ML, Martini C.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0708376

Bibliografisk träff 2007-06-08

Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists.

Jeong LS, Choe SA, Gunaga P, Kim HO, Lee HW, Lee SK, Tosh DK, Patel A, Palaniappan KK, Gao ZG, Jacobson KA, Moon HR.

J Med Chem · research support, n.i.h., intramural; research support, non-u.s. gov't; journal article · DOI 10.1021/jm070259t

Bibliografisk träff 2007-04-08

Chemical genetics reveals a complex functional ground state of neural stem cells.

Diamandis P, Wildenhain J, Clarke ID, Sacher AG, Graham J, Bellows DS, Ling EK, Ward RJ, Jamieson LG, Tyers M, Dirks PB.

Nat Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1038/nchembio873

Bibliografisk träff 2007-02-20

N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor.

Volpini R, Dal Ben D, Lambertucci C, Taffi S, Vittori S, Klotz KN, Cristalli G.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm060963u

Bibliografisk träff 2006-02-17

N6-ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists.

Zhu R, Frazier CR, Linden J, Macdonald TL.

Bioorg Med Chem Lett · journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2006.01.110

Bibliografisk träff 2005-03-01

Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.

Cappellacci L, Franchetti P, Pasqualini M, Petrelli R, Vita P, Lavecchia A, Novellino E, Costa B, Martini C, Klotz KN, Grifantini M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm049408n

Bibliografisk träff 2005-03-01

(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.

Tchilibon S, Joshi BV, Kim SK, Duong HT, Gao ZG, Jacobson KA.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm049580r

Bibliografisk träff 2004-10-01

Design and synthesis of 3'-ureidoadenosine-5'-uronamides: effects of the 3'-ureido group on binding to the A3 adenosine receptor.

Jeong LS, Kim MJ, Kim HO, Gao ZG, Kim SK, Jacobson KA, Chun MW.

Bioorg Med Chem Lett · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.bmcl.2004.07.042

Bibliografisk träff 2004-10-01

Synthesis and biological evaluation of novel N6-[4-(substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 adenosine receptor agonists.

Baraldi PG, Fruttarolo F, Tabrizi MA, Romagnoli R, Preti D, Bovero A, Pineda de Las Infantas MJ, Moorman A, Varani K, Borea PA.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0408161

Bibliografisk träff 2004-09-01

2-Pyrazolyl-N(6)-substituted adenosine derivatives as high affinity and selective adenosine A(3) receptor agonists.

Elzein E, Palle V, Wu Y, Maa T, Zeng D, Zablocki J.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm049682h

Bibliografisk träff 2003-08-01

N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor.

Jeong LS, Jin DZ, Kim HO, Shin DH, Moon HR, Gunaga P, Chun MW, Kim YC, Melman N, Gao ZG, Jacobson KA.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm034098e

Bibliografisk träff 2003-03-01

Design, synthesis and binding affinity of 3'-fluoro analogues of Cl-IB-MECA as adenosine A3 receptor ligands.

Lim MH, Kim HO, Moon HR, Lee SJ, Chun MW, Gao ZG, Melman N, Jacobson KA, Kim JH, Jeong LS.

Bioorg Med Chem Lett · comparative study; research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/s0960-894x(03)00027-1

Bibliografisk träff 2003-01-01

3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor.

DeNinno MP, Masamune H, Chenard LK, DiRico KJ, Eller C, Etienne JB, Tickner JE, Kennedy SP, Knight DR, Kong J, Oleynek JJ, Tracey WR, Hill RJ.

J Med Chem · journal article · DOI 10.1021/jm0255724

Bibliografisk träff 2002-09-01

Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.

Gao ZG, Kim SK, Biadatti T, Chen W, Lee K, Barak D, Kim SG, Johnson CR, Jacobson KA.

J Med Chem · research-article; journal article · DOI 10.1021/jm020211+

Bibliografisk träff 2001-11-01

Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides.

Jacobson KA, Gao ZG, Chen A, Barak D, Kim SA, Lee K, Link A, Rompaey PV, van Calenbergh S, Liang BT.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm010232o

Bibliografisk träff 1998-08-01

Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.

Li AH, Moro S, Melman N, Ji XD, Jacobson KA.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm980093j

Bibliografisk träff 1998-07-01

The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles.

Mogensen JP, Roberts SM, Bowler AN, Thomsen C, Knutsen LJ.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(98)00302-3

Bibliografisk träff 1994-10-01

2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors.

Kim HO, Ji XD, Siddiqi SM, Olah ME, Stiles GL, Jacobson KA.

J Med Chem · research-article; journal article · DOI 10.1021/jm00047a018

Bibliografisk träff 1987-05-01

Increased creatine kinase activity in pituitary tumours of rat and man.

Silverlight JJ, Prysor-Jones RA, Hoffman J, Jenkins JS.

Acta Endocrinol (Copenh) · research support, non-u.s. gov't; journal article · DOI 10.1530/acta.0.1150131