Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.
McCluskey A, Sim AT, Sakoff JA.
J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/jm010066k PUBLIKATIONSREGISTRET
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Hashida T, Masuda S, Uemoto S, Saito H, Tanaka K, Inui K.
Clin Pharmacol Ther · clinical trial; research support, non-u.s. gov't; journal article · DOI 10.1067/mcp.2001.115142Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo.
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Rabinowitz M, Seneci P, Rossi T, Dal Cin M, Deal M, Terstappen G.
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J Med Chem · journal article · DOI 10.1021/jm980252zSynthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties.
Christner C, Wyrwa R, Marsch S, Küllertz G, Thiericke R, Grabley S, Schumann D, Fischer G.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm991038tP-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies.
Wandel C, Kim RB, Kajiji S, Guengerich P, Wilkinson GR, Wood AJ.
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Yokogawa K, Takahashi M, Tamai I, Konishi H, Nomura M, Moritani S, Miyamoto K, Tsuji A.
Pharm Res · research support, non-u.s. gov't; journal article · DOI 10.1023/a:101899331277332-Indolyl ether derivatives of ascomycin: three-dimensional structures of complexes with FK506-binding protein.
Becker JW, Rotonda J, Cryan JG, Martin M, Parsons WH, Sinclair PJ, Wiederrecht G, Wong F.
J Med Chem · journal article · DOI 10.1021/jm9806042Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity.
Armstrong HM, Wong F, Holmes MA, Sinclair PJ, Goulet MT, Dumont FJ, Staruch MJ, Koprak S, Peterson LB, Rosa R, Wilusz MB, Wiederrecht GJ, Cryan JG, Wyvratt MJ, Parsons WH.
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Hersperger R, Schuler W, Zenke G.
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Hamilton GS, Steiner JP.
J Med Chem · review; journal article · DOI 10.1021/jm980307xC32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential.
Goulet MT, McAlpine SR, Staruch MJ, Koprak S, Dumont FJ, Cryan JG, Wiederrecht GJ, Rosa R, Wilusz MB, Peterson LB, Wyvratt MJ, Parsons WH.
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Wagner R, Rhoades TA, Or YS, Lane BC, Hsieh G, Mollison KW, Luly JR.
J Med Chem · comparative study; journal article · DOI 10.1021/jm960066yStudies on an immunosuppressive macrolactam, ascomycin: synthesis of a C-33 hydroxyl derivative.
Kawai M, Gunawardana IW, Mollison KW, Hsieh GC, Lane BC, Luly JR.
Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(98)00145-0Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
Schuetz EG, Beck WT, Schuetz JD.
Mol Pharmacol · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1016/s0026-895x(25)08713-9The C-32 triacetyl-L-rhamnose derivative of ascomycin: a potent, orally active macrolactone immunosuppressant.
Koch K, Newborg MF, Hanson DC, Cooper K, Shepard RM, Biehl ML, Biggers MS, Ramchandani M, Schulte G, Snyder JR.
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J Biol Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/s0021-9258(18)53221-xNew analgesic drugs derived from phencyclidine.
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