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Publikationer i urvalet

50 träffar

Bibliografisk träff 2004-09-01

The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.

Du LP, Tsai KC, Li MY, You QD, Xia L.

Bioorg Med Chem Lett · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2004.06.070

Bibliografisk träff 2004-02-01

Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.

Lombardo F, Obach RS, Shalaeva MY, Gao F.

J Med Chem · journal article · DOI 10.1021/jm030408h

Bibliografisk träff 2003-08-01

Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.

Keserü GM.

Bioorg Med Chem Lett · comparative study; journal article · DOI 10.1016/s0960-894x(03)00492-x

Bibliografisk träff 2003-06-01

Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine.

Aslanian R, Mutahi Mw, Shih NY, Piwinski JJ, West R, Williams SM, She S, Wu RL, Hey JA.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(03)00357-3

Bibliografisk träff 2002-06-01

Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.

Lombardo F, Obach RS, Shalaeva MY, Gao F.

J Med Chem · journal article · DOI 10.1021/jm0200409

Bibliografisk träff 2001-11-01

Rational use of in vitro P-glycoprotein assays in drug discovery.

Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS.

J Pharmacol Exp Ther · journal article · DOI 10.1016/s0022-3565(24)29270-3

Bibliografisk träff 2001-11-01

Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules.

Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K.

Pharm Res · research support, non-u.s. gov't; journal article · DOI 10.1023/a:1013070128668

Bibliografisk träff 2001-07-01

ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.

Lombardo F, Shalaeva MY, Tupper KA, Gao F.

J Med Chem · journal article · DOI 10.1021/jm0100990

Bibliografisk träff 2000-06-01

QSAR model for drug human oral bioavailability.

Yoshida F, Topliss JG.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0000564

Bibliografisk träff 2000-01-01

Human UDP-glucuronosyltransferases: metabolism, expression, and disease.

Tukey RH, Strassburg CP.

Annu Rev Pharmacol Toxicol · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; review; journal article · DOI 10.1146/annurev.pharmtox.40.1.581

Bibliografisk träff 1998-12-01

Dual antagonists of platelet activating factor and histamine. 3. Synthesis, biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines.

Piwinski JJ, Wong JK, Green MJ, Kaminski JJ, Colizzo F, Albanese MM, Ganguly AK, Billah MM, Anthes JC, West RE.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(98)00626-x

Bibliografisk träff 1998-03-01

Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist.

Pagliara A, Testa B, Carrupt PA, Jolliet P, Morin C, Morin D, Urien S, Tillement JP, Rihoux JP.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm9704311

Bibliografisk träff 1995-09-01

New antihistamines: substituted piperazine and piperidine derivatives as novel H1-antagonists.

Abou-Gharbia M, Moyer JA, Nielsen ST, Webb M, Patel U.

J Med Chem · journal article · DOI 10.1021/jm00020a018

Bibliografisk träff 1991-04-01

Optical isomers of rocastine and close analogues: synthesis and H1 antihistaminic activity of its enantiomers and their structural relationship to the classical antihistamines.

Sleevi MC, Cale AD, Gero TW, Jaques LW, Welstead WJ, Johnson AF, Kilpatrick BF, Demian I, Nolan JC, Jenkins H.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00108a012

Bibliografisk träff 1991-01-01

Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines.

Piwinski JJ, Wong JK, Green MJ, Ganguly AK, Billah MM, West RE, Kreutner W.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00105a069

Bibliografisk träff 1985-12-01

New antihistaminic N-heterocyclic 4-piperidinamines. 1. Synthesis and antihistaminic activity of N-(4-piperidinyl)-1H-benzimidazol-2-amines.

Janssens F, Torremans J, Janssen M, Stokbroekx RA, Luyckx M, Janssen PA.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00150a028

Bibliografisk träff 1985-05-01

New antihistaminic theophylline or theobromine derivatives.

Pascal JC, Beranger S, Pinhas H, Poizot A, Désiles JP.

J Med Chem · journal article · DOI 10.1021/jm50001a019

Bibliografisk träff 1985-03-01

[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.

McNeal ET, Lewandowski GA, Daly JW, Creveling CR.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00381a019

Bibliografisk träff 1984-12-01

Functional group contributions to drug-receptor interactions.

Andrews PR, Craik DJ, Martin JL.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00378a021

Bibliografisk träff 1981-03-01

Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity.

Unger SH, Chiang GH.

J Med Chem · journal article · DOI 10.1021/jm00135a006