Immunosuppressive cyclolignans.
Gordaliza M, Faircloth GT, Castro MA, Miguel del Corral JM, López-Vázquez ML, San Feliciano A.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm960023h PUBLIKATIONSREGISTRET
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Publikationer i urvalet
50 träffarCyclosporin A treatment induces overexpression of P-glycoprotein in the kidney and other tissues.
Jetté L, Beaulieu E, Leclerc JM, Béliveau R.
Am J Physiol · research support, non-u.s. gov't; journal article · DOI 10.1152/ajprenal.1996.270.5.f756Cyclosporin analogs modified in the 3,7,8-positions: substituent effects on peptidylprolyl isomerase inhibition and immunosuppressive activity are nonadditive.
Hu MK, Badger A, Rich DH.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00021a005Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.
Schinkel AH, Wagenaar E, van Deemter L, Mol CA, Borst P.
J Clin Invest · research support, non-u.s. gov't; research-article; journal article · DOI 10.1172/jci118214The role of water molecules in the structure-based design of (5-hydroxynorvaline)-2-cyclosporin: synthesis, biological activity, and crystallographic analysis with cyclophilin A.
Mikol V, Papageorgiou C, Borer X.
J Med Chem · journal article · DOI 10.1021/jm00017a020Preparation and in vitro activities of ethers of [D-serine]8-cyclosporin.
Eberle MK, Hiestand P, Jutzi-Eme AM, Nuninger F, Zihlmann HR.
J Med Chem · comparative study; journal article · DOI 10.1021/jm00011a004The C-32 triacetyl-L-rhamnose derivative of ascomycin: a potent, orally active macrolactone immunosuppressant.
Koch K, Newborg MF, Hanson DC, Cooper K, Shepard RM, Biehl ML, Biggers MS, Ramchandani M, Schulte G, Snyder JR.
J Med Chem · journal article · DOI 10.1021/jm00008a001The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Leier I, Jedlitschky G, Buchholz U, Cole SP, Deeley RG, Keppler D.
J Biol Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/s0021-9258(18)46856-1Improved binding affinity for cyclophilin A by a cyclosporin derivative singly modified at its effector domain.
Papageorgiou C, Florineth A, Mikol V.
J Med Chem · journal article · DOI 10.1021/jm00048a002Analogues of the marine immunosuppressant microcolin A: preparation and biological activity.
Koehn FE, McConnell OJ, Longley RE, Sennett SH, Reed JK.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00045a024Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein.
Rao US, Scarborough GA.
Mol Pharmacol · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1016/s0026-895x(25)10165-xPharmacokinetics of orally and intravenously administered cyclosporine in pre-kidney transplant patients.
Aweeka FT, Tomlanovich SJ, Prueksaritanont T, Gupta SK, Benet LZ.
J Clin Pharmacol · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1002/j.1552-4604.1994.tb03967.xSolvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations.
el Tayar N, Mark AE, Vallat P, Brunne RM, Testa B, van Gunsteren WF.
J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00076a002Human P-glycoprotein transports cyclosporin A and FK506.
Saeki T, Ueda K, Tanigawara Y, Hori R, Komano T.
J Biol Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/s0021-9258(18)53221-xMethylsulfamic acid esters. A new chemical class of oral antiarthritic agents.
Walsh DA, Lo YS, Shamblee DA, Welstead WJ, Nolan JC, Graff G.
J Med Chem · journal article · DOI 10.1021/jm00170a003Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration.
Gupta SK, Manfro RC, Tomlanovich SJ, Gambertoglio JG, Garovoy MR, Benet LZ.
J Clin Pharmacol · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1002/j.1552-4604.1990.tb01868.xSynthesis, conformation, and immunosuppressive activities of three analogues of cyclosporin A modified in the 1-position.
Aebi JD, Deyo DT, Sun CQ, Guillaume D, Dunlap B, Rich DH.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00165a018Synthesis, conformation, and immunosuppressive activity of a conformationally restricted cyclosporine lactam analogue.
Aebi JD, Guillaume D, Dunlap BE, Rich DH.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00117a022Didemnins and tunichlorin: novel natural products from the marine tunicate Trididemnum solidum.
Rinehart KL, Kishore V, Bible KC, Sakai R, Sullins DW, Li KM.
J Nat Prod · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/np50055a001Synthesis and antimitogenic activities of four analogues of cyclosporin A modified in the 1-position.
Rich DH, Dhaon MK, Dunlap B, Miller SP.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00156a014