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Publikationer i urvalet

50 träffar

Bibliografisk träff 2010-11-11

Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

Kmentova I, Sutherland HS, Palmer BD, Blaser A, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA, Thompson AM.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm101288t

Bibliografisk träff 2010-10-11

PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

Ahmad Z, Peloquin CA, Singh RP, Derendorf H, Tyagi S, Ginsberg A, Grosset JH, Nuermberger EL.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00849-10

Bibliografisk träff 2010-08-13

Synthesis of non-purine analogs of 6-aryl-9-benzylpurines, and their antimycobacterial activities. Compounds modified in the imidazole ring.

Khoje AD, Kulendrn A, Charnock C, Wan B, Franzblau S, Gundersen LL.

Bioorg Med Chem · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2010.08.016

Bibliografisk träff 2010-05-03

Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.

Sokolova AY, Wyllie S, Patterson S, Oza SL, Read KD, Fairlamb AH.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00332-10

Bibliografisk träff 2010-01-01

Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

Palmer BD, Thompson AM, Sutherland HS, Blaser A, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm901207n

Bibliografisk träff 2010-01-01

Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains.

Sutherland HS, Blaser A, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Palmer BD, Denny WA, Thompson AM.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm901378u

Bibliografisk träff 2010-01-01

Rational design of 5-phenyl-3-isoxazolecarboxylic acid ethyl esters as growth inhibitors of Mycobacterium tuberculosis. a potent and selective series for further drug development.

Lilienkampf A, Pieroni M, Wan B, Wang Y, Franzblau SG, Kozikowski AP.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm901273n

Bibliografisk träff 2009-12-23

Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.

Hans RH, Guantai EM, Lategan C, Smith PJ, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K.

Bioorg Med Chem Lett · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2009.12.062

Bibliografisk träff 2009-06-29

Role of the Mycobacterium tuberculosis P55 efflux pump in intrinsic drug resistance, oxidative stress responses, and growth.

Ramón-García S, Martín C, Thompson CJ, Aínsa JA.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00550-09

Bibliografisk träff 2009-03-01

Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles.

Kim P, Zhang L, Manjunatha UH, Singh R, Patel S, Jiricek J, Keller TH, Boshoff HI, Barry CE, Dowd CS.

J Med Chem · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm801246z

Bibliografisk träff 2009-03-01

Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.

Kim P, Kang S, Boshoff HI, Jiricek J, Collins M, Singh R, Manjunatha UH, Niyomrattanakit P, Zhang L, Goodwin M, Dick T, Keller TH, Dowd CS, Barry CE.

J Med Chem · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/jm801374t

Bibliografisk träff 2009-01-12

Dry powder nitroimidazopyran antibiotic PA-824 aerosol for inhalation.

Sung JC, Garcia-Contreras L, Verberkmoes JL, Peloquin CA, Elbert KJ, Hickey AJ, Edwards DA.

Antimicrob Agents Chemother · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.01389-08

Bibliografisk träff 2008-12-15

New drugs against tuberculosis: problems, progress, and evaluation of agents in clinical development.

van den Boogaard J, Kibiki GS, Kisanga ER, Boeree MJ, Aarnoutse RE.

Antimicrob Agents Chemother · review-article; review; journal article · DOI 10.1128/aac.00749-08

Bibliografisk träff 2008-11-01

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.

Singh R, Manjunatha U, Boshoff HI, Ha YH, Niyomrattanakit P, Ledwidge R, Dowd CS, Lee IY, Kim P, Zhang L, Kang S, Keller TH, Jiricek J, Barry CE.

Science · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; journal article · DOI 10.1126/science.1164571

Bibliografisk träff 2008-07-14

Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis.

Vicente E, Villar R, Burguete A, Solano B, Pérez-Silanes S, Aldana I, Maddry JA, Lenaerts AJ, Franzblau SG, Cho SH, Monge A, Goldman RC.

Antimicrob Agents Chemother · research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.00379-08

Bibliografisk träff 2008-03-07

Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.

Li X, Manjunatha UH, Goodwin MB, Knox JE, Lipinski CA, Keller TH, Barry CE, Dowd CS.

Bioorg Med Chem Lett · research support, n.i.h., intramural; research-article; journal article · DOI 10.1016/j.bmcl.2008.03.011

Bibliografisk träff 2007-01-08

Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.

Cho SH, Warit S, Wan B, Hwang CH, Pauli GF, Franzblau SG.

Antimicrob Agents Chemother · research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.00055-06

Bibliografisk träff 2006-11-01

OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.

Matsumoto M, Hashizume H, Tomishige T, Kawasaki M, Tsubouchi H, Sasaki H, Shimokawa Y, Komatsu M.

PLoS Med · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pmed.0030466

Bibliografisk träff 2005-06-01

New small-molecule synthetic antimycobacterials.

Ballell L, Field RA, Duncan K, Young RJ.

Antimicrob Agents Chemother · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; review-article; review; journal article · DOI 10.1128/aac.49.6.2153-2163.2005

Bibliografisk träff 2000-06-01

A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis.

Stover CK, Warrener P, VanDevanter DR, Sherman DR, Arain TM, Langhorne MH, Anderson SW, Towell JA, Yuan Y, McMurray DN, Kreiswirth BN, Barry CE, Baker WR.

Nature · journal article · DOI 10.1038/35016103