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Publikationer i urvalet

37 träffar

Bibliografisk träff 2014-10-29

The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.

Long J, Li B, Rodriguez-Blanco J, Pastori C, Volmar CH, Wahlestedt C, Capobianco A, Bai F, Pei XH, Ayad NG, Robbins DJ.

J Biol Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1074/jbc.m114.595348

Bibliografisk träff 2014-07-03

Control of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151.

Gallagher SJ, Mijatov B, Gunatilake D, Gowrishankar K, Tiffen J, James W, Jin L, Pupo G, Cullinane C, McArthur GA, Tummino PJ, Rizos H, Hersey P.

Pigment Cell Melanoma Res · research support, non-u.s. gov't; journal article · DOI 10.1111/pcmr.12282

Bibliografisk träff 2014-06-06

The epigenetic regulator I-BET151 induces BIM-dependent apoptosis and cell cycle arrest of human melanoma cells.

Gallagher SJ, Mijatov B, Gunatilake D, Tiffen JC, Gowrishankar K, Jin L, Pupo GM, Cullinane C, Prinjha RK, Smithers N, McArthur GA, Rizos H, Hersey P.

J Invest Dermatol · research support, non-u.s. gov't; journal article · DOI 10.1038/jid.2014.243

Bibliografisk träff 2014-05-22

I-BET151 selectively regulates IL-6 production.

Barrett E, Brothers S, Wahlestedt C, Beurel E.

Biochim Biophys Acta · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bbadis.2014.05.013

Bibliografisk träff 2013-12-13

Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762.

Chaidos A, Caputo V, Gouvedenou K, Liu B, Marigo I, Chaudhry MS, Rotolo A, Tough DF, Smithers NN, Bassil AK, Chapman TD, Harker NR, Barbash O, Tummino P, Al-Mahdi N, Haynes AC, Cutler L, Le B, Rahemtulla A, Roberts I, Kleijnen M, Witherington JJ, Parr NJ, Prinjha RK, Karadimitris A.

Blood · research support, non-u.s. gov't; journal article · DOI 10.1182/blood-2013-01-478420

Bibliografisk träff 2012-02-24

Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).

Seal J, Lamotte Y, Donche F, Bouillot A, Mirguet O, Gellibert F, Nicodeme E, Krysa G, Kirilovsky J, Beinke S, McCleary S, Rioja I, Bamborough P, Chung CW, Gordon L, Lewis T, Walker AL, Cutler L, Lugo D, Wilson DM, Witherington J, Lee K, Prinjha RK.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2012.02.041

Bibliografisk träff 2012-02-08

From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.

Mirguet O, Lamotte Y, Donche F, Toum J, Gellibert F, Bouillot A, Gosmini R, Nguyen VL, Delannée D, Seal J, Blandel F, Boullay AB, Boursier E, Martin S, Brusq JM, Krysa G, Riou A, Tellier R, Costaz A, Huet P, Dudit Y, Trottet L, Kirilovsky J, Nicodeme E.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2012.01.125