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Publikationer i urvalet

18 träffar

Bibliografisk träff 2023-08-14

Design, synthesis, antitumor activity, and molecular dynamics simulations of novel sphingosine kinase 2 inhibitors.

Wang S, Huo Y, Zhang J, Li L, Cao F, Song Y, Zhang Y, Yang K.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2023.117441

Bibliografisk träff 2021-05-10

Kinase Inhibitors as Underexplored Antiviral Agents.

García-Cárceles J, Caballero E, Gil C, Martínez A.

J Med Chem · research support, non-u.s. gov't; review-article; review; journal article · DOI 10.1021/acs.jmedchem.1c00302

Bibliografisk träff 2021-02-04

Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.

Raghuvanshi R, Bharate SB.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.0c01467

Bibliografisk träff 2021-01-08

Rational design of SphK inhibitors using crystal structures aided by computer.

Ding T, Zhi Y, Xie W, Yao Q, Liu B.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2021.113164

Bibliografisk träff 2020-12-29

Probing the substitution pattern of indole-based scaffold reveals potent and selective sphingosine kinase 2 inhibitors.

Congdon M, Fritzemeier RG, Kharel Y, Brown AM, Serbulea V, Bevan DR, Lynch KR, Santos WL.

Eur J Med Chem · research-article; journal article · DOI 10.1016/j.ejmech.2020.113121

Bibliografisk träff 2020-08-08

Structure-activity relationship studies and bioactivity evaluation of 1,2,3-triazole containing analogues as a selective sphingosine kinase-2 inhibitors.

Tangadanchu VKR, Jiang H, Yu Y, Graham TJA, Liu H, Rogers BE, Gropler R, Perlmutter J, Tu Z.

Eur J Med Chem · research-article; journal article · DOI 10.1016/j.ejmech.2020.112713

Bibliografisk träff 2020-07-28

Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization.

Hengst JA, Hegde S, Paulson RF, Yun JK.

Bioorg Med Chem Lett · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2020.127453

Bibliografisk träff 2019-03-27

Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2.

Adams DR, Tawati S, Berretta G, Rivas PL, Baiget J, Jiang Z, Alsfouk A, Mackay SP, Pyne NJ, Pyne S.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.9b00162

Bibliografisk träff 2017-04-25

Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity.

Childress ES, Kharel Y, Brown AM, Bevan DR, Lynch KR, Santos WL.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.7b00233

Bibliografisk träff 2017-03-29

Identification of selective inhibitors of sphingosine kinases 1 and 2 through a structure-activity relationship study of 4-epi-jaspine B.

Ohno H, Honda M, Hamada N, Miyagaki J, Iwata A, Otsuki K, Maruyama T, Nakamura S, Nakanishi I, Inuki S, Fujii N, Oishi S.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2017.03.059

Bibliografisk träff 2016-05-24

Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice.

Xi M, Ge J, Wang X, Sun C, Liu T, Fang L, Xiao Q, Yin D.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2016.05.047

Bibliografisk träff 2016-02-03

From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II).

Aurelio L, Scullino CV, Pitman MR, Sexton A, Oliver V, Davies L, Rebello RJ, Furic L, Creek DJ, Pitson SM, Flynn BL.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.5b01439

Bibliografisk träff 2015-03-23

Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors.

Congdon MD, Childress ES, Patwardhan NN, Gumkowski J, Morris EA, Kharel Y, Lynch KR, Santos WL.

Bioorg Med Chem Lett · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2015.03.041

Bibliografisk träff 2015-02-13

Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors.

Patwardhan NN, Morris EA, Kharel Y, Raje MR, Gao M, Tomsig JL, Lynch KR, Santos WL.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm501760d

Bibliografisk träff 2014-02-11

Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors.

Plano D, Amin S, Sharma AK.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/jm4011687

Bibliografisk träff 2013-06-20

Structure guided design of a series of sphingosine kinase (SphK) inhibitors.

Gustin DJ, Li Y, Brown ML, Min X, Schmitt MJ, Wanska M, Wang X, Connors R, Johnstone S, Cardozo M, Cheng AC, Jeffries S, Franks B, Li S, Shen S, Wong M, Wesche H, Xu G, Carlson TJ, Plant M, Morgenstern K, Rex K, Schmitt J, Coxon A, Walker N, Kayser F, Wang Z.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2013.06.030

Bibliografisk träff 2013-01-01

Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells.

Byun HS, Pyne S, Macritchie N, Pyne NJ, Bittman R.

Medchemcomm · research-article; journal article · DOI 10.1039/c3md00201b

Bibliografisk träff 2012-01-26

Effect of alkyl chain length on sphingosine kinase 2 selectivity.

Knott K, Kharel Y, Raje MR, Lynch KR, Santos WL.

Bioorg Med Chem Lett · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2012.01.050