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Publikationer i urvalet

9 träffar

Bibliografisk träff 2024-02-01

Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500).

Black WC, Abdoli A, An X, Auger A, Beaulieu P, Bernatchez M, Caron C, Chefson A, Crane S, Diallo M, Dorich S, Fader LD, Ferraro GB, Fournier S, Gao Q, Ginzburg Y, Hamel M, Han Y, Jones P, Lanoix S, Lacbay CM, Leclaire ME, Levy M, Mamane Y, Mulani A, Papp R, Pellerin C, Picard A, Skeldon A, Skorey K, Stocco R, St-Onge M, Truchon JF, Truong VL, Zimmermann M, Zinda M, Roulston A.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.3c01917

Bibliografisk träff 2024-02-01

Discovery of the first ataxia telangiectasia and Rad3-related (ATR) degraders for cancer treatment.

Huang L, Shao J, Lai W, Gu H, Yang J, Shi S, Wufoyrwoth S, Song Z, Zou Y, Xu Y, Zhu Q.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2024.116159

Bibliografisk träff 2023-06-05

Pharmacological activity and mechanism of pyrazines.

Hou W, Dai W, Huang H, Liu SL, Liu J, Huang LJ, Huang XH, Zeng JL, Gan ZW, Zhang ZY, Lan JX.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2023.115544

Bibliografisk träff 2022-02-12

Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo.

Bin H, Chen P, Wu M, Wang F, Lin G, Pan S, Liu J, Mu B, Nan J, Huang Q, Li L, Yang S.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114187

Bibliografisk träff 2021-05-10

Kinase Inhibitors as Underexplored Antiviral Agents.

García-Cárceles J, Caballero E, Gil C, Martínez A.

J Med Chem · research support, non-u.s. gov't; review-article; review; journal article · DOI 10.1021/acs.jmedchem.1c00302

Bibliografisk träff 2021-02-04

Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.

Raghuvanshi R, Bharate SB.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.0c01467

Bibliografisk träff 2019-05-16

Rational Design of 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular Polar Interactions of a New Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase Inhibitor.

Knegtel R, Charrier JD, Durrant S, Davis C, O'Donnell M, Storck P, MacCormick S, Kay D, Pinder J, Virani A, Twin H, Griffiths M, Reaper P, Littlewood P, Young S, Golec J, Pollard J.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.9b00426

Bibliografisk träff 2017-01-16

Discovery of pyrazolopyrimidine derivatives as novel inhibitors of ataxia telangiectasia and rad3 related protein (ATR).

Ramachandran SA, Jadhavar PS, Singh MP, Sharma A, Bagle GN, Quinn KP, Wong PY, Protter AA, Rai R, Pham SM, Lindquist JN.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2017.01.045

Bibliografisk träff 2016-10-19

New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.

van Kuijk SJA, Parvathaneni NK, Niemans R, van Gisbergen MW, Carta F, Vullo D, Pastorekova S, Yaromina A, Supuran CT, Dubois LJ, Winum JY, Lambin P.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.10.037