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Publikationer i urvalet

14 träffar

Bibliografisk träff 2016-03-25

Needle-Free Delivery of Acetalated Dextran-Encapsulated AR-12 Protects Mice from Francisella tularensis Lethal Challenge.

Hoang KV, Curry H, Collier MA, Borteh H, Bachelder EM, Schlesinger LS, Gunn JS, Ainslie KM.

Antimicrob Agents Chemother · research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.02228-15

Bibliografisk träff 2016-03-01

Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function.

Booth L, Shuch B, Albers T, Roberts JL, Tavallai M, Proniuk S, Zukiwski A, Wang D, Chen CS, Bottaro D, Ecroyd H, Lebedyeva IO, Dent P.

Oncotarget · research-article; journal article · DOI 10.18632/oncotarget.7349

Bibliografisk träff 2016-01-05

Host-mediated Leishmania donovani treatment using AR-12 encapsulated in acetalated dextran microparticles.

Collier MA, Peine KJ, Gautam S, Oghumu S, Varikuti S, Borteh H, Papenfuss TL, Sataoskar AR, Bachelder EM, Ainslie KM.

Int J Pharm · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.ijpharm.2016.01.004

Bibliografisk träff 2015-09-29

Molecular docking and molecular dynamics studies reveal structural basis of inhibition and selectivity of inhibitors EGCG and OSU-03012 toward glucose regulated protein-78 (GRP78) overexpressed in glioblastoma.

Bhattacharjee R, Devi A, Mishra S.

J Mol Model · research support, non-u.s. gov't; journal article · DOI 10.1007/s00894-015-2801-3

Bibliografisk träff 2015-08-01

OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies.

Booth L, Roberts JL, Tavallai M, Nourbakhsh A, Chuckalovcak J, Carter J, Poklepovic A, Dent P.

J Cell Physiol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1002/jcp.24977

Bibliografisk träff 2015-07-01

GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease.

Booth L, Roberts JL, Cash DR, Tavallai S, Jean S, Fidanza A, Cruz-Luna T, Siembiba P, Cycon KA, Cornelissen CN, Dent P.

J Cell Physiol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1002/jcp.24919

Bibliografisk träff 2015-03-01

HSPA5/Dna K may be a useful target for human disease therapies.

Booth L, Roberts JL, Dent P.

DNA Cell Biol · research-article; journal article · DOI 10.1089/dna.2015.2808

Bibliografisk träff 2014-12-04

Celecoxib derivative OSU-03012 inhibits the proliferation and activation of hepatic stellate cells by inducing cell senescence.

Zhang J, Wang M, Zhang Z, Luo Z, Liu F, Liu J.

Mol Med Rep · research support, non-u.s. gov't; journal article · DOI 10.3892/mmr.2014.3048

Bibliografisk träff 2014-10-22

Acetalated dextran encapsulated AR-12 as a host-directed therapy to control Salmonella infection.

Hoang KV, Borteh HM, Rajaram MV, Peine KJ, Curry H, Collier MA, Homsy ML, Bachelder EM, Gunn JS, Schlesinger LS, Ainslie KM.

Int J Pharm · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ijpharm.2014.10.022

Bibliografisk träff 2014-09-29

Sensitization of intracellular Salmonella enterica serovar Typhimurium to aminoglycosides in vitro and in vivo by a host-targeted antimicrobial agent.

Lo JH, Kulp SK, Chen CS, Chiu HC.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.03778-14

Bibliografisk träff 2014-08-07

Regulation of OSU-03012 toxicity by ER stress proteins and ER stress-inducing drugs.

Booth L, Roberts JL, Cruickshanks N, Grant S, Poklepovic A, Dent P.

Mol Cancer Ther · research-article; journal article; research support, n.i.h., extramural · DOI 10.1158/1535-7163.mct-14-0172

Bibliografisk träff 2013-08-01

OSU-03012, a non-Cox inhibiting celecoxib derivative, induces apoptosis of human esophageal carcinoma cells through a p53/Bax/cytochrome c/caspase-9-dependent pathway.

Liu J, Qin CK, Lv W, Zhao Q, Qin CY.

Anticancer Drugs · journal article · DOI 10.1097/cad.0b013e328362469f

Bibliografisk träff 2013-05-24

OSU-03012 sensitizes breast cancers to lapatinib-induced cell killing: a role for Nck1 but not Nck2.

West NW, Garcia-Vargas A, Chalfant CE, Park MA.

BMC Cancer · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1186/1471-2407-13-256

Bibliografisk träff 2012-02-01

OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing.

Booth L, Cazanave SC, Hamed HA, Yacoub A, Ogretmen B, Chen CS, Grant S, Dent P.

Cancer Biol Ther · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research-article; journal article · DOI 10.4161/cbt.13.4.18877