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Publikationer i urvalet

22 träffar

Bibliografisk träff 2016-09-09

Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome.

Melis N, Rubera I, Cougnon M, Giraud S, Mograbi B, Belaid A, Pisani DF, Huber SM, Lacas-Gervais S, Fragaki K, Blondeau N, Vigne P, Frelin C, Hauet T, Duranton C, Tauc M.

J Am Soc Nephrol · research-article; journal article · DOI 10.1681/asn.2016010012

Bibliografisk träff 2016-04-01

Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species.

Liu RR, Lv YS, Tang YX, Wang YF, Chen XL, Zheng XX, Xie SZ, Cai Y, Yu J, Zhang XN.

Oncotarget · research-article; journal article · DOI 10.18632/oncotarget.8324

Bibliografisk träff 2016-04-01

N1-guanyl-1,7-diaminoheptane enhances the chemosensitivity of NSCLC cells to cetuximab through inhibition of eukaryotic translation initiation factor 5A2 activation.

Wang X, Jiang R, Cui EH, Feng WM, Guo HH, Gu DH, Tang CW, Xue T, Bao Y.

Eur Rev Med Pharmacol Sci · journal article

Bibliografisk träff 2016-01-08

Eukaryotic translation initiation factor 5A (eIF5A) is essential for HIF-1α activation in hypoxia.

Tariq M, Ito A, Ishfaq M, Bradshaw E, Yoshida M.

Biochem Biophys Res Commun · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbrc.2016.01.024

Bibliografisk träff 2015-09-26

Bifunctional activity of deoxyhypusine synthase/hydroxylase from Trichomonas vaginalis.

Quintas-Granados LI, Carvajal Gamez BI, Villalpando JL, Ortega-Lopez J, Arroyo R, Azuara-Liceaga E, Álvarez-Sánchez ME.

Biochimie · research support, non-u.s. gov't; journal article · DOI 10.1016/j.biochi.2015.09.027

Bibliografisk träff 2015-08-10

N1-Guanyl-1,7-Diaminoheptane Sensitizes Estrogen Receptor Negative Breast Cancer Cells to Doxorubicin by Preventing Epithelial-Mesenchymal Transition through Inhibition of Eukaryotic Translation Initiation Factor 5A2 Activation.

Liu Y, Liu R, Fu P, Du F, Hong Y, Yao M, Zhang X, Zheng S.

Cell Physiol Biochem · research support, non-u.s. gov't; journal article · DOI 10.1159/000430209

Bibliografisk träff 2015-06-23

Hypusination of eukaryotic initiation factor 5A via cAMP-PKA-ERK1/2 pathway is required for ligand-induced downregulation of LH receptor mRNA expression in the ovary.

Gulappa T, Menon B, Menon KM.

Mol Cell Endocrinol · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.mce.2015.06.014

Bibliografisk träff 2014-11-07

Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2.

Xu G, Yu H, Shi X, Sun L, Zhou Q, Zheng D, Shi H, Li N, Zhang X, Shao G.

BMC Pulm Med · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/1471-2466-14-174

Bibliografisk träff 2014-10-15

Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients.

Bandino A, Geerts D, Koster J, Bachmann AS.

Cell Oncol (Dordr) · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1007/s13402-014-0201-9

Bibliografisk träff 2014-09-14

The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A.

Oliverio S, Corazzari M, Sestito C, Piredda L, Ippolito G, Piacentini M.

Amino Acids · research support, non-u.s. gov't; journal article · DOI 10.1007/s00726-014-1821-0

Bibliografisk träff 2014-06-02

Cryptosporidium parvum has an active hypusine biosynthesis pathway.

Mittal N, Morada M, Tripathi P, Gowri VS, Mandal S, Quirch A, Park MH, Yarlett N, Madhubala R.

Mol Biochem Parasitol · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.molbiopara.2014.05.005

Bibliografisk träff 2014-03-11

In silico design, synthesis, and screening of novel deoxyhypusine synthase inhibitors targeting HIV-1 replication.

Schroeder M, Kolodzik A, Pfaff K, Priyadarshini P, Krepstakies M, Hauber J, Rarey M, Meier C.

ChemMedChem · research support, non-u.s. gov't; journal article · DOI 10.1002/cmdc.201300481

Bibliografisk träff 2014-02-04

Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a "humanized" transgenic mouse model of type 1 diabetes.

Imam S, Mirmira RG, Jaume JC.

Am J Physiol Endocrinol Metab · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1152/ajpendo.00537.2013

Bibliografisk träff 2014-01-07

N1-guanyl-1,7-diaminoheptane sensitizes bladder cancer cells to doxorubicin by preventing epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2 activation.

Yang J, Yu H, Shen M, Wei W, Xia L, Zhao P.

Cancer Sci · research support, non-u.s. gov't; research-article; journal article · DOI 10.1111/cas.12328

Bibliografisk träff 2014-01-02

Inhibition of eIF5A results in aberrant uterine natural killer cell function and embryo loss in mice.

Qin X, Liu X, Shan B, Shi L, Sharma S, Wu J, Lin Y.

Am J Reprod Immunol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1111/aji.12194

Bibliografisk träff 2014-01-01

Hypusine modification of the ribosome-binding protein eIF5A, a target for new anti-inflammatory drugs: understanding the action of the inhibitor GC7 on a murine macrophage cell line.

de Almeida OP, Toledo TR, Rossi D, Rossetto Dde B, Watanabe TF, Galvão FC, Medeiros AI, Zanelli CF, Valentini SR.

Curr Pharm Des · research support, non-u.s. gov't; review; journal article · DOI 10.2174/13816128113199990036

Bibliografisk träff 2013-11-06

Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes.

Colvin SC, Maier B, Morris DL, Tersey SA, Mirmira RG.

J Biol Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1074/jbc.m113.473942

Bibliografisk träff 2013-08-16

N1-guanyl-1,7-diaminoheptane (GC7) enhances the therapeutic efficacy of doxorubicin by inhibiting activation of eukaryotic translation initiation factor 5A2 (eIF5A2) and preventing the epithelial-mesenchymal transition in hepatocellular carcinoma cells.

Lou B, Fan J, Wang K, Chen W, Zhou X, Zhang J, Lin S, Lv F, Chen Y.

Exp Cell Res · research support, non-u.s. gov't; journal article · DOI 10.1016/j.yexcr.2013.08.010

Bibliografisk träff 2012-08-21

Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies.

Preukschas M, Hagel C, Schulte A, Weber K, Lamszus K, Sievert H, Pällmann N, Bokemeyer C, Hauber J, Braig M, Balabanov S.

PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0043468

Bibliografisk träff 2009-04-01

Cloning and characterization of hypusine-containing protein eIF5A from the olive flounder Paralichthys olivaceus.

Kong HJ, Hong GE, Kim WJ, Kim YO, Nam BH, Lee CH, Do JW, Lee JH, Lee SJ, Kim KK.

Comp Biochem Physiol B Biochem Mol Biol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.cbpb.2009.03.012

Bibliografisk träff 2006-10-16

Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax.

Njuguna JT, Nassar M, Hoerauf A, Kaiser AE.

BMC Microbiol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/1471-2180-6-91

Bibliografisk träff 2000-02-01

Cell cycle arrest in archaea by the hypusination inhibitor N(1)-guanyl-1,7-diaminoheptane.

Jansson BP, Malandrin L, Johansson HE.

J Bacteriol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/jb.182.4.1158-1161.2000