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Publikationer i urvalet

28 träffar

Bibliografisk träff 2017-01-18

Mass Spectrometric Characterization of an Acid-Labile Adduct Formed with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and Albumin in Humans.

Wang Y, Villalta PW, Peng L, Dingley K, Malfatti MA, Turteltaub KW, Turesky RJ.

Chem Res Toxicol · research-article; validation study; journal article · DOI 10.1021/acs.chemrestox.6b00426

Bibliografisk träff 2016-04-18

Bioactivation of Heterocyclic Aromatic Amines by UDP Glucuronosyltransferases.

Cai T, Yao L, Turesky RJ.

Chem Res Toxicol · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.chemrestox.6b00046

Bibliografisk träff 2015-08-13

Genotoxicity of three food processing contaminants in transgenic mice expressing human sulfotransferases 1A1 and 1A2 as assessed by the in vivo alkaline single cell gel electrophoresis assay.

Høie AH, Svendsen C, Brunborg G, Glatt H, Alexander J, Meinl W, Husøy T.

Environ Mol Mutagen · brief-report; research support, non-u.s. gov't; journal article · DOI 10.1002/em.21963

Bibliografisk träff 2015-04-10

Mass Spectrometric Characterization of Human Serum Albumin Adducts Formed with N-Oxidized Metabolites of 2-Amino-1-methylphenylimidazo[4,5-b]pyridine in Human Plasma and Hepatocytes.

Wang Y, Peng L, Bellamri M, Langouët S, Turesky RJ.

Chem Res Toxicol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.chemrestox.5b00075

Bibliografisk träff 2014-04-09

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is selectively toxic to primary dopaminergic neurons in vitro.

Griggs AM, Agim ZS, Mishra VR, Tambe MA, Director-Myska AE, Turteltaub KW, McCabe GP, Rochet JC, Cannon JR.

Toxicol Sci · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1093/toxsci/kfu060

Bibliografisk träff 2013-12-13

Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.

Vlaming ML, Teunissen SF, van de Steeg E, van Esch A, Wagenaar E, Brunsveld L, de Greef TF, Rosing H, Schellens JH, Beijnen JH, Schinkel AH.

Mol Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1124/mol.113.088823

Bibliografisk träff 2010-07-29

Development and validation of a liquid chromatography-tandem mass spectrometry assay for the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in plasma, urine, bile, intestinal contents, faeces and eight selected tissues from mice.

Teunissen SF, Vlaming ML, Rosing H, Schellens JH, Schinkel AH, Beijnen JH.

J Chromatogr B Analyt Technol Biomed Life Sci · journal article · DOI 10.1016/j.jchromb.2010.07.012

Bibliografisk träff 2007-07-17

Glucuronidation of PhIP and N-OH-PhIP by UDP-glucuronosyltransferase 1A10.

Dellinger RW, Chen G, Blevins-Primeau AS, Krzeminski J, Amin S, Lazarus P.

Carcinogenesis · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1093/carcin/bgm164

Bibliografisk träff 2006-11-20

Enhanced glutathione S-transferase expression in 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine-resistant IEC-18 cells.

Teubner W, Fuchs JI, Steinberg P.

Cell Biol Toxicol · journal article · DOI 10.1007/s10565-006-0094-0

Bibliografisk träff 2005-08-31

Malignant transformation of human colon epithelial cells by benzo[c]phenanthrene dihydrodiolepoxides as well as 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

Herbst U, Fuchs JI, Teubner W, Steinberg P.

Toxicol Appl Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.taap.2005.07.016

Bibliografisk träff 2004-08-01

Human UDP-glucuronosyltransferase 1A1 is the primary enzyme responsible for the N-glucuronidation of N-hydroxy-PhIP in vitro.

Malfatti MA, Felton JS.

Chem Res Toxicol · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/tx049898m

Bibliografisk träff 2003-05-28

Metabolic activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.

Fretland AJ, Devanaboyina US, Doll MA, Zhao S, Xiao GH, Hein DW.

Toxicol Sci · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1093/toxsci/kfg133

Bibliografisk träff 2003-01-01

Mutagenesis and DNA adduct formation in the mouse mammary gland exposed to 2-hydroxyamino-1-methyl-6-phenylimidazo-[4,5-b]pyridine in whole organ culture.

Snyderwine EG, Yoon HS, Knight-Jones LP, Tran M, Schut HA, Yu M.

Mutagenesis · comparative study; journal article · DOI 10.1093/mutage/18.1.7

Bibliografisk träff 2002-08-01

Resveratrol modulates human mammary epithelial cell O-acetyltransferase, sulfotransferase, and kinase activation of the heterocyclic amine carcinogen N-hydroxy-PhIP.

Dubuisson JG, Dyess DL, Gaubatz JW.

Cancer Lett · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/s0304-3835(02)00061-7

Bibliografisk träff 2001-11-01

Determination of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and its metabolite 2-hydroxyamino-PhIP by liquid chromatography/electrospray ionization-ion trap mass spectrometry.

Prabhu S, Lee MJ, Hu WY, Winnik B, Yang I, Buckley B, Hong JY.

Anal Biochem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1006/abio.2001.5392

Bibliografisk träff 2001-09-01

Cytosolic enzymes from rat tissues that activate the cooked meat mutagen metabolite N-Hydroxyamino-1-methyl-6- phenylimidazo[4,5-b]pyridine (N-OH-PhIP).

Dubuisson JG, Murph WS, Griffin SR, Gaubatz JW.

J Nutr Biochem · journal article · DOI 10.1016/s0955-2863(01)00168-1

Bibliografisk träff 2001-07-01

N-glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N_hydroxy-PhIP by specific human UDP-glucuronosyltransferases.

Malfatti MA, Felton JS.

Carcinogenesis · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1093/carcin/22.7.1087

Bibliografisk träff 2001-03-01

Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation.

Galijatovic A, Otake Y, Walle UK, Walle T.

Pharm Res · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1023/a:1011019417236

Bibliografisk träff 2001-01-01

Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1.

Nelson CP, Kidd LC, Sauvageot J, Isaacs WB, De Marzo AM, Groopman JD, Nelson WG, Kensler TW.

Cancer Res · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article

Bibliografisk träff 2000-06-01

N-acetyltransferase-dependent activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine: formation of 2-amino-1-methyl-6-(5-hydroxy)phenylimidazo [4,5-b]pyridine, a possible biomarker for the reactive dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

Frandsen H, Alexander J.

Carcinogenesis · research support, non-u.s. gov't; journal article · DOI 10.1093/carcin/21.5.197

Bibliografisk träff 1999-06-01

Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4, 5-b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved.

Nowell SA, Massengill JS, Williams S, Radominska-Pandya A, Tephly TR, Cheng Z, Strassburg CP, Tukey RH, MacLeod SL, Lang NP, Kadlubar FF.

Carcinogenesis · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1093/carcin/20.6.1107

Bibliografisk träff 1998-09-01

Bioactivation of the proximal food mutagen 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) to DNA-binding species by human mammary gland enzymes.

Dubuisson JG, Gaubatz JW.

Nutrition · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/s0899-9007(98)00106-3

Bibliografisk träff 1996-03-01

Cytogenetic effects of a food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-beta]pyridine (PhIP), and its metabolite, 2-hydroxyamino-1-methy-6-phenylimidazo[4,5-beta]pyridine (N-OH-PhIP), on human and Chinese hamster cells in vitro.

Otsuka C, Miura KF, Satoh T, Hatanaka M, Wakabayashi K, Ishidate M.

Mutat Res · journal article · DOI 10.1016/0165-1218(95)00082-8

Bibliografisk träff 1995-04-01

Cytotoxicity, DNA adduct formation and DNA repair induced by 2-hydroxyamino-3-methylimidazo[4,5-f]quinoline and 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in cultured human mammary epithelial cells.

Fan L, Schut HA, Snyderwine EG.

Carcinogenesis · journal article · DOI 10.1093/carcin/16.4.775

Bibliografisk träff 1994-12-01

Activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b] pyridine by cDNA-expressed human and rat arylsulfotransferases.

Ozawa S, Chou HC, Kadlubar FF, Nagata K, Yamazoe Y, Kato R.

Jpn J Cancer Res · comparative study; research support, non-u.s. gov't; research-article; journal article · DOI 10.1111/j.1349-7006.1994.tb02933.x

Bibliografisk träff 1994-03-01

Mutation and repair induced by the carcinogen 2-(hydroxyamino)-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in the dihydrofolate reductase gene of Chinese hamster ovary cells and conformational modeling of the dG-C8-PhIP adduct in DNA.

Carothers AM, Yuan W, Hingerty BE, Broyde S, Grunberger D, Snyderwine EG.

Chem Res Toxicol · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/tx00038a015

Bibliografisk träff 1994-02-01

2-Hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine induction of recombinational mutations in mammalian cell lines as detected by DNA fingerprinting.

Kitazawa T, Kominami R, Tanaka R, Wakabayashi K, Nagao M.

Mol Carcinog · research support, non-u.s. gov't; journal article · DOI 10.1002/mc.2940090203

Bibliografisk träff 1990-11-01

Role of sulfation and acetylation in the activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine to intermediates which bind DNA.

Buonarati MH, Turteltaub KW, Shen NH, Felton JS.

Mutat Res · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/0165-7992(90)90048-o