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Publikationer i urvalet

50 träffar

Bibliografisk träff 2023-04-08

Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors.

Rullo M, La Spada G, Miniero DV, Gottinger A, Catto M, Delre P, Mastromarino M, Latronico T, Marchese S, Mangiatordi GF, Binda C, Linusson A, Liuzzi GM, Pisani L.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2023.115352

Bibliografisk träff 2022-09-23

Design, synthesis, in-vitro, in-vivo and ex-vivo pharmacology of thiazolidine-2,4-dione derivatives as selective and reversible monoamine oxidase-B inhibitors.

Jadoon R, Aamir Javed M, Saeed Jan M, Ikram M, Ikram M, Mahnashi MH, Sadiq A, Shahid M, Rashid U.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2022.128994

Bibliografisk träff 2022-09-08

Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catechol-O-methyltransferase inhibitor.

Chavarria D, Benfeito S, Soares P, Lima C, Garrido J, Serrão P, Soares-da-Silva P, Remião F, Oliveira PJ, Borges F.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114740

Bibliografisk träff 2022-06-03

Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties.

Reis J, Fernandes C, Salem H, Maia M, Tomé C, Benfeito S, Teixeira J, Oliveira PJ, Uriarte E, Ortuso F, Alcaro S, Bagetta D, Cagide F, Borges F.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114507

Bibliografisk träff 2022-06-01

Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors.

Paolino M, Rullo M, Maramai S, de Candia M, Pisani L, Catto M, Mugnaini C, Brizzi A, Cappelli A, Olivucci M, Corelli F, Altomare CD.

RSC Med Chem · research-article; journal article · DOI 10.1039/d2md00042c

Bibliografisk träff 2022-05-09

Evaluation of chromane derivatives: Promising privileged scaffolds for lead discovery within Alzheimer's disease.

Moutayakine A, Marques C, López Ó, Bagetta D, Leitzbach L, Hagenow S, Carreiro EP, Stark H, Alcaro S, Fernández-Bolaños JG, Burke AJ.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2022.116807

Bibliografisk träff 2022-04-25

Discovery of 3, 6-disubstituted isobenzofuran-1(3H)-ones as novel inhibitors of monoamine oxidases.

Liu K, Zhou S, Zhou J, Bo R, Wang X, Xu T, Yuan Y, Xu B.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2022.128748

Bibliografisk träff 2022-03-29

Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines.

Grychowska K, Olejarz-Maciej A, Blicharz K, Pietruś W, Karcz T, Kurczab R, Koczurkiewicz P, Doroz-Płonka A, Latacz G, Keeri AR, Piska K, Satała G, Pęgiel J, Trybała W, Jastrzębska-Więsek M, Bojarski AJ, Lamaty F, Partyka A, Walczak M, Krawczyk M, Malikowska-Racia N, Popik P, Zajdel P.

Eur J Med Chem · journal article; case reports · DOI 10.1016/j.ejmech.2022.114329

Bibliografisk träff 2022-02-23

Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies.

Rullo M, Cipolloni M, Catto M, Colliva C, Miniero DV, Latronico T, de Candia M, Benicchi T, Linusson A, Giacchè N, Altomare CD, Pisani L.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.1c01784

Bibliografisk träff 2021-12-01

Enhancing monoamine oxidase B inhibitory activity via chiral fluorination: Structure-activity relationship, biological evaluation, and molecular docking study.

Wang Z, Yi C, Chen K, Wang T, Deng K, Jin C, Hao G.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.114025

Bibliografisk träff 2021-07-23

Ugi Reaction Synthesis of Oxindole-Lactam Hybrids as Selective Butyrylcholinesterase Inhibitors.

Brandão P, López Ó, Leitzbach L, Stark H, Fernández-Bolaños JG, Burke AJ, Pineiro M.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.1c00344

Bibliografisk träff 2021-07-16

Mapping Chromone-3-Phenylcarboxamide Pharmacophore: Quid Est Veritas?

Mesiti F, Gaspar A, Chavarria D, Maruca A, Rocca R, Gil Martins E, Barreiro S, Silva R, Fernandes C, Gul S, Keminer O, Alcaro S, Borges F.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c00510

Bibliografisk träff 2021-06-05

Synthesis and biological evaluation of 3-styrylchromone derivatives as selective monoamine oxidase B inhibitors.

Takao K, Takemura Y, Nagai J, Kamauchi H, Hoshi K, Mabashi R, Uesawa Y, Sugita Y.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2021.116255

Bibliografisk träff 2021-05-18

Designing Out PXR Activity on Drug Discovery Projects: A Review of Structure-Based Methods, Empirical and Computational Approaches.

Hall A, Chanteux H, Ménochet K, Ledecq M, Schulze MED.

J Med Chem · review; journal article · DOI 10.1021/acs.jmedchem.0c02245

Bibliografisk träff 2021-04-19

Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation.

Kong H, Meng X, Hou R, Yang X, Han J, Xie Z, Duan Y, Liao C.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2021.128051

Bibliografisk träff 2021-01-13

4-Oxoquinolines and monoamine oxidase: When tautomerism matters.

Mesiti F, Maruca A, Silva V, Rocca R, Fernandes C, Remião F, Uriarte E, Alcaro S, Gaspar A, Borges F.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113183

Bibliografisk träff 2020-11-19

Computational Fragment-Based Design Facilitates Discovery of Potent and Selective Monoamine Oxidase-B (MAO-B) Inhibitor.

Jin CF, Wang ZZ, Chen KZ, Xu TF, Hao GF.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.0c01663

Bibliografisk träff 2020-10-08

Pyrimido[1,2-b]indazole derivatives: Selective inhibitors of human monoamine oxidase B with neuroprotective activity.

Jismy B, El Qami A, Pišlar A, Frlan R, Kos J, Gobec S, Knez D, Abarbri M.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112911

Bibliografisk träff 2020-08-22

A dual-acting 5-HT6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties.

Canale V, Grychowska K, Kurczab R, Ryng M, Keeri AR, Satała G, Olejarz-Maciej A, Koczurkiewicz P, Drop M, Blicharz K, Piska K, Pękala E, Janiszewska P, Krawczyk M, Walczak M, Chaumont-Dubel S, Bojarski AJ, Marin P, Popik P, Zajdel P.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112765

Bibliografisk träff 2020-08-21

Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of Alzheimer's disease.

Łażewska D, Bajda M, Kaleta M, Zaręba P, Doroz-Płonka A, Siwek A, Alachkar A, Mogilski S, Saad A, Kuder K, Olejarz-Maciej A, Godyń J, Stary D, Sudoł S, Więcek M, Latacz G, Walczak M, Handzlik J, Sadek B, Malawska B, Kieć-Kononowicz K.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112743

Bibliografisk träff 2020-08-18

Novel 1,3,4-thiadiazole compounds as potential MAO-A inhibitors - design, synthesis, biological evaluation and molecular modelling.

Sağlık BN, Kaya Çavuşoğlu B, Acar Çevik U, Osmaniye D, Levent S, Özkay Y, Kaplancıklı ZA.

RSC Med Chem · research-article; journal article · DOI 10.1039/d0md00150c

Bibliografisk träff 2020-07-23

Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors.

Guglielmi P, Mathew B, Secci D, Carradori S.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2020.112650

Bibliografisk träff 2019-10-16

Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.

Chavarria D, Fernandes C, Silva V, Silva C, Gil-Martins E, Soares P, Soares P, Silva T, Silva R, Remião F, Oliveira PJ, Borges F.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.111770

Bibliografisk träff 2019-06-19

Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors.

Tzvetkov NT, Stammler HG, Georgieva MG, Russo D, Faraone I, Balacheva AA, Hristova S, Atanasov AG, Milella L, Antonov L, Gastreich M.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.06.041

Bibliografisk träff 2019-02-08

Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.

Cheng K, Li S, Lv X, Tian Y, Kong H, Huang X, Duan Y, Han J, Xie Z, Liao C.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2019.02.008

Bibliografisk träff 2018-11-13

(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.

Tzvetkov NT, Stammler HG, Hristova S, Atanasov AG, Antonov L.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.11.009

Bibliografisk träff 2018-11-09

Novel monoamine oxidase inhibitors based on the privileged 2-imidazoline molecular framework.

Shetnev A, Osipyan A, Baykov S, Sapegin A, Chirkova Z, Korsakov M, Petzer A, Engelbrecht I, Petzer JP.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2018.11.018

Bibliografisk träff 2018-10-31

4-tert-Pentylphenoxyalkyl derivatives - Histamine H3 receptor ligands and monoamine oxidase B inhibitors.

Łażewska D, Olejarz-Maciej A, Kaleta M, Bajda M, Siwek A, Karcz T, Doroz-Płonka A, Cichoń U, Kuder K, Kieć-Kononowicz K.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2018.10.048

Bibliografisk träff 2018-10-10

Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.

Pisani L, Iacobazzi RM, Catto M, Rullo M, Farina R, Denora N, Cellamare S, Altomare CD.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.10.016

Bibliografisk träff 2018-09-11

Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.

Reis J, Cagide F, Valencia ME, Teixeira J, Bagetta D, Pérez C, Uriarte E, Oliveira PJ, Ortuso F, Alcaro S, Rodríguez-Franco MI, Borges F.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.07.056

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Publikationer i urvalet

Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors.

Design, synthesis, in-vitro, in-vivo and ex-vivo pharmacology of thiazolidine-2,4-dione derivatives as selective and reversible monoamine oxidase-B inhibitors.

Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catechol-O-methyltransferase inhibitor.

Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties.

Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors.

Evaluation of chromane derivatives: Promising privileged scaffolds for lead discovery within Alzheimer's disease.

Discovery of 3, 6-disubstituted isobenzofuran-1(3H)-ones as novel inhibitors of monoamine oxidases.

Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines.

Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies.

Enhancing monoamine oxidase B inhibitory activity via chiral fluorination: Structure-activity relationship, biological evaluation, and molecular docking study.

Ugi Reaction Synthesis of Oxindole-Lactam Hybrids as Selective Butyrylcholinesterase Inhibitors.

Mapping Chromone-3-Phenylcarboxamide Pharmacophore: <i>Quid Est Veritas</i>?

Synthesis and biological evaluation of 3-styrylchromone derivatives as selective monoamine oxidase B inhibitors.

Designing Out PXR Activity on Drug Discovery Projects: A Review of Structure-Based Methods, Empirical and Computational Approaches.

Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation.

4-Oxoquinolines and monoamine oxidase: When tautomerism matters.

Computational Fragment-Based Design Facilitates Discovery of Potent and Selective Monoamine Oxidase-B (MAO-B) Inhibitor.

Pyrimido[1,2-b]indazole derivatives: Selective inhibitors of human monoamine oxidase B with neuroprotective activity.

A dual-acting 5-HT<sub>6</sub> receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties.

Rational design of new multitarget histamine H<sub>3</sub> receptor ligands as potential candidates for treatment of Alzheimer's disease.

Novel 1,3,4-thiadiazole compounds as potential MAO-A inhibitors - design, synthesis, biological evaluation and molecular modelling.

Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors.

Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.

Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors.

Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure.

(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.

Novel monoamine oxidase inhibitors based on the privileged 2-imidazoline molecular framework.

4-tert-Pentylphenoxyalkyl derivatives - Histamine H<sub>3</sub> receptor ligands and monoamine oxidase B inhibitors.

Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.

Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.