Recent advances and challenges of revolutionizing drug-resistant tuberculosis treatment.
Wei X, Yue L, Zhao B, Jiang N, Lei H, Zhai X.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2024.116785 PUBLIKATIONSREGISTRET
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24 träffarUnraveling Dilemmas and Lacunae in the Escalating Drug Resistance of <i>Mycobacterium tuberculosis</i> to Bedaquiline, Delamanid, and Pretomanid.
Negi A, Perveen S, Gupta R, Singh PP, Sharma R.
J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.3c01892A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.
Sutherland JJ, Yonchev D, Fekete A, Urban L.
Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9Discovery and preclinical evaluations of JBD0131, a novel nitrodihydro-imidazooxazole anti-tuberculosis agent.
Luo W, Huang Z, Xu D, Yang M, Zhu Y, Shen L, Chen S, Tao X, Bin W, Hu Y, Franzblau SG, Jiang N, Wei Y, Wei X, Ding CZ.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2022.128871Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
Ma Z, He S, Yuan Y, Zhuang Z, Liu Y, Wang H, Chen J, Xu X, Ding C, Molodtsov V, Lin W, Robertson GT, Weiss WJ, Pulse M, Nguyen P, Duncan L, Doyle T, Ebright RH, Lynch AS.
J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.1c02045Tuberculosis drug discovery: Progression and future interventions in the wake of emerging resistance.
Perveen S, Kumari D, Singh K, Sharma R.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2021.114066Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity.
Pacheco JDS, Costa DS, Cunha-Júnior EF, Andrade-Neto VV, Fairlamb AH, Wyllie S, Goulart MOF, Santos DC, Silva TL, Alves MA, Costa PRR, Dias AG, Torres-Santos EC.
ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.1c001932-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F<sub>420</sub>)-Dependent Nitroreductase (Ddn).
Jian Y, Forbes HE, Hulpia F, Risseeuw MDP, Caljon G, Munier-Lehmann H, Boshoff HIM, Van Calenbergh S.
J Med Chem · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.0c01374Molecule Property Analyses of Active Compounds for <i>Mycobacterium tuberculosis</i>.
Makarov V, Salina E, Reynolds RC, Kyaw Zin PP, Ekins S.
J Med Chem · research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.9b02075Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2'-Oxidase.
Karabanovich G, Dušek J, Savková K, Pavliš O, Pávková I, Korábečný J, Kučera T, Kočová Vlčková H, Huszár S, Konyariková Z, Konečná K, Jand'ourek O, Stolaříková J, Korduláková J, Vávrová K, Pávek P, Klimešová V, Hrabálek A, Mikušová K, Roh J.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.9b00912Discovery and evaluation of novel nitrodihydroimidazooxazoles as promising anti-tuberculosis agents.
Tao X, Gao C, Huang ZG, Luo W, Liu KL, Peng CT, Ding CZ, Li J, Chen SH, Yu LT.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2019.06.055Drug-resistance in <i>Mycobacterium tuberculosis</i>: where we stand.
Mabhula A, Singh V.
Medchemcomm · review-article; review; journal article · DOI 10.1039/c9md00057gNitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases.
Ang CW, Jarrad AM, Cooper MA, Blaskovich MAT.
J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.7b001436-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases.
Thompson AM, Blaser A, Palmer BD, Anderson RF, Shinde SS, Launay D, Chatelain E, Maes L, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2017.03.069S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.
Karabanovich G, Němeček J, Valášková L, Carazo A, Konečná K, Stolaříková J, Hrabálek A, Pavliš O, Pávek P, Vávrová K, Roh J, Klimešová V.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2016.11.041Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis.
Thompson AM, O'Connor PD, Blaser A, Yardley V, Maes L, Gupta S, Launay D, Martin D, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.5b01699Synthesis and Biological Evaluation of Polar Functionalities Containing Nitrodihydroimidazooxazoles as Anti-TB Agents.
Yempalla KR, Munagala G, Singh S, Kour G, Sharma S, Chib R, Kumar S, Wazir P, Singh GD, Raina S, Bharate SS, Khan IA, Vishwakarma RA, Singh PP.
ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.5b002021-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria.
Karabanovich G, Roh J, Smutný T, Němeček J, Vicherek P, Stolaříková J, Vejsová M, Dufková I, Vávrová K, Pávek P, Klimešová V, Hrabálek A.
Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2014.05.069Tuberculosis: the drug development pipeline at a glance.
Villemagne B, Crauste C, Flipo M, Baulard AR, Déprez B, Willand N.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2012.02.033Structure-activity relationships for amide-, carbamate-, and urea-linked analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
Blaser A, Palmer BD, Sutherland HS, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Thompson AM, Denny WA.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm2012276Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
Kmentova I, Sutherland HS, Palmer BD, Blaser A, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA, Thompson AM.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm101288tNew drugs against tuberculosis: problems, progress, and evaluation of agents in clinical development.
van den Boogaard J, Kibiki GS, Kisanga ER, Boeree MJ, Aarnoutse RE.
Antimicrob Agents Chemother · review-article; review; journal article · DOI 10.1128/aac.00749-08Synthesis and antituberculosis activity of a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles.
Sasaki H, Haraguchi Y, Itotani M, Kuroda H, Hashizume H, Tomishige T, Kawasaki M, Matsumoto M, Komatsu M, Tsubouchi H.
J Med Chem · journal article · DOI 10.1021/jm060957yOPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.
Matsumoto M, Hashizume H, Tomishige T, Kawasaki M, Tsubouchi H, Sasaki H, Shimokawa Y, Komatsu M.
PLoS Med · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pmed.0030466