Hydroxyurea derivatives of irofulven with improved antitumor efficacy.
Staake MD, Kashinatham A, McMorris TC, Estes LA, Kelner MJ, Kelner MJ.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2016.02.028 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
9 träffarStructure-activity studies of urea, carbamate, and sulfonamide derivatives of acylfulvene.
McMorris TC, Chimmani R, Alisala K, Staake MD, Banda G, Kelner MJ, Kelner MJ.
J Med Chem · journal article · DOI 10.1021/jm901384sConjugates of the fungal cytotoxin illudin M with improved tumour specificity.
Schobert R, Biersack B, Knauer S, Ocker M.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2008.08.015Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Obach RS, Lombardo F, Waters NJ.
Drug Metab Dispos · journal article · DOI 10.1124/dmd.108.020479Synthesis and antitumor activity of amine analogs of irofulven.
McMorris TC, Chimmani R, Gurram M, Staake MD, Kelner MJ, Kelner MJ.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2007.10.040Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity.
Gong J, Neels JF, Yu X, Kensler TW, Peterson LA, Sturla SJ.
J Med Chem · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1021/jm051104tReaction of irofulven with zinc and acid.
McMorris TC, Moon SS, Kelner MJ, Kelner MJ.
J Nat Prod · comparative study; journal article · DOI 10.1021/np0204085Preparation and biological activity of amino acid and peptide conjugates of antitumor hydroxymethylacylfulvene.
McMorris TC, Yu J, Ngo HT, Wang H, Kelner MJ, Kelner MJ.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0000315(Hydroxymethyl)acylfulvene: an illudin derivative with superior antitumor properties.
McMorris TC, Kelner MJ, Kelner MJ, Wang W, Yu J, Estes LA, Taetle R.
J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/np960450y