Adaptive neuro-fuzzy inference system: an instant and architecture-free predictor for improved QSAR studies.
Loukas YL.
J Med Chem · comparative study; journal article · DOI 10.1021/jm000226c PUBLIKATIONSREGISTRET
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15 träffarNew drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
Queener SF.
J Med Chem · research support, u.s. gov't, p.h.s.; review; journal article · DOI 10.1021/jm00024a001Application of neural networks: quantitative structure-activity relationships of the derivatives of 2,4-diamino-5-(substituted-benzyl)pyrimidines as DHFR inhibitors.
So SS, Richards WG.
J Med Chem · comparative study; journal article · DOI 10.1021/jm00095a016On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase.
Selassie CD, Li RL, Poe M, Hansch C.
J Med Chem · comparative study; journal article · DOI 10.1021/jm00105a008On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships.
Selassie CD, Fang ZX, Li RL, Hansch C, Debnath G, Klein TE, Langridge R, Kaufman BT.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00128a035The hypothetical active site lattice. An approach to modelling active sites from data on inhibitor molecules.
Doweyko AM.
J Med Chem · journal article · DOI 10.1021/jm00402a025Quantitative structure-activity relationships for the inhibition of Escherichia coli dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines.
Li RL, Poe M.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00397a017Inhibition of chicken liver dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines. A quantitative structure-activity relationship and graphics analysis.
Selassie CD, Fang ZX, Li RL, Hansch C, Klein T, Langridge R, Kaufman BT.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00155a006Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate.
Coats EA, Genther CS, Selassie CD, Strong CD, Hansch C.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00150a026Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.
Selassie CD, Hansch C, Khwaja TA, Dias CB, Pentecost S.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00369a019Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, X-ray crystallography, and computer graphics in structure-activity analysis.
Hansch C, Li R, Blaney JM, Langridge R.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00349a003Inhibition by 5-(substituted-benzyl)-2,4-diaminopyrimidines of murine tumor (L5178Y) cell cultures sensitive to and resistant to methotrexate. Further evidence for the sensitivity of resistant cells to hydrophobic drugs.
Selassie CD, Li R, Hansch C, Khwaja TA, Dias CB.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00347a007A comparison of the inhibitory action of 5-(substituted-benzyl)-2,4-diaminopyrimidines on dihydrofolate reductase from chicken liver with that from bovine liver.
Li R, Hansch C, Kaufman BT.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00346a0202,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 5. 3',5'-Dimethoxy-4'-substituted-benzyl analogues of trimethoprim.
Roth B, Aig E, Rauckman BS, Strelitz JZ, Phillips AP, Ferone R, Bushby SR, Sigel CW.
J Med Chem · journal article · DOI 10.1021/jm00140a005Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted-benzyl)-2,4-diaminopyrimidines.
Li RL, Dietrich SW, Hansch C.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00137a012