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Publikationer i urvalet

21 träffar

Bibliografisk träff 2010-02-01

Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.

Varma MV, Obach RS, Rotter C, Miller HR, Chang G, Steyn SJ, El-Kattan A, Troutman MD.

J Med Chem · journal article · DOI 10.1021/jm901371v

Bibliografisk träff 2009-08-01

Physicochemical determinants of human renal clearance.

Varma MV, Feng B, Obach RS, Troutman MD, Chupka J, Miller HR, El-Kattan A.

J Med Chem · journal article · DOI 10.1021/jm900403j

Bibliografisk träff 2008-04-21

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Obach RS, Lombardo F, Waters NJ.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.108.020479

Bibliografisk träff 2005-07-01

Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.

Jolivette LJ, Ward KW.

J Pharm Sci · comparative study; journal article · DOI 10.1002/jps.20373

Bibliografisk träff 2004-08-01

[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].

Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.

Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2

Bibliografisk träff 2000-06-01

QSAR model for drug human oral bioavailability.

Yoshida F, Topliss JG.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0000564

Bibliografisk träff 1994-07-01

Evaluation of negative inotropic and antiarrhythmic effects of class 1 antiarrhythmic drugs.

Nawada T, Tanaka Y, Hirai S, Hisatome I, Hasegawa J, Kotake H, Mashiba H.

Int J Clin Pharmacol Ther · journal article

Bibliografisk träff 1992-05-01

Selectivity of class I antiarrhythmic agents, disopyramide, pirmenol, and pentisomide for peripheral muscarinic M2 and M3 receptors.

Endou M, Hattori Y, Gando S, Kanno M.

J Cardiovasc Pharmacol · journal article

Bibliografisk träff 1992-01-01

Voltage-dependent modification of Vmax recovery from use-dependent block by pirmenol in guinea pig papillary muscles: comparison with other class I drugs.

Nakaya H, Shishido Y, Oyama Y, Kanno M.

J Cardiovasc Pharmacol · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1097/00005344-199201000-00020

Bibliografisk träff 1991-09-01

[Pharmacological analysis of drug interactions of disopyramide and its congeners with peripheral muscarinic acetylcholine receptors].

Endou M.

Hokkaido Igaku Zasshi · journal article; english abstract

Bibliografisk träff 1991-01-01

Effects of pirmenol on electrical induction of sustained ventricular tachycardia in a seven-day-old canine myocardial infarction.

Nitta J, Nogami A, Aonuma K, Akimoto H, Chung YH, Takahashi A, Iesaka Y, Marumo F, Hiraoka M.

J Cardiovasc Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1097/00005344-199101000-00008

Bibliografisk träff 1991-01-01

Pirmenol: an antiarrhythmic drug with unique electrocardiographic features--a double-blind placebo-controlled comparison with quinidine.

Salerno DM, Fifield J, Farmer C, Hodges M.

Clin Cardiol · comparative study; clinical trial; research support, non-u.s. gov't; randomized controlled trial; journal article · DOI 10.1002/clc.4960140107

Bibliografisk träff 1990-05-01

Pirmenol, a new antiarrhythmic drug with potassium- and sodium-channel blocking activity; a voltage-clamp study in rabbit Purkinje fibres.

Reichardt B, Konzen G, Hauswirth O.

Naunyn Schmiedebergs Arch Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1007/bf00176341

Bibliografisk träff 1990-05-01

Comparison of cardiovascular effects of pirmenol with those of disopyramide in isolated canine heart preparations cross-circulated with a donor dog.

Sugiyama A, Motomura S, Tamura K, Hashimoto K.

Jpn J Pharmacol · comparative study; journal article · DOI 10.1254/jjp.53.97

Bibliografisk träff 1988-09-01

Efficacy and pharmacokinetics of oral pirmenol, a new antiarrhythmic drug.

Garg DC, Jallad NS, Singh S, Ng KF, Weidler DJ.

J Clin Pharmacol · controlled clinical trial; clinical trial; research support, non-u.s. gov't; journal article · DOI 10.1002/j.1552-4604.1988.tb03221.x

Bibliografisk träff 1988-05-01

The relation of the kinetics of pirmenol to its antiarrhythmic efficacy.

Johnson BF, Haffajee CI, Woodman T, Sloan KL.

J Clin Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1002/j.1552-4604.1988.tb05748.x

Bibliografisk träff 1988-03-01

Pirmenol: preclinical pharmacology.

Kaplan HR, Mertz TE, Steffe TJ.

Angiology · comparative study; review; journal article

Bibliografisk träff 1988-03-01

Clinical pharmacology and pharmacokinetics of pirmenol.

Reiter MJ.

Angiology · review; journal article

Bibliografisk träff 1987-06-01

Preclinical and clinical pharmacokinetics of pirmenol.

Chang T.

Am J Cardiol · journal article · DOI 10.1016/0002-9149(87)90139-1

Bibliografisk träff 1982-02-01

Pirmenol, a new antiarrhythmic agent: initial study of efficacy, safety and pharmacokinetics.

Hammill SC, Shand DG, Routledge PA, Hindman MC, Baker JT, Pritchett EL.

Circulation · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1161/01.cir.65.2.369

Bibliografisk träff 1980-02-01

Effects of pirmenol HCl on electrophysiologic properties of cardiac Purkinje fibers.

Reder RF, Danilo P, Rosen MR.

Eur J Pharmacol · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/0014-2999(80)90071-0