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Publikationer i urvalet

19 träffar

Bibliografisk träff 2013-08-16

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Morgan RE, van Staden CJ, Chen Y, Kalyanaraman N, Kalanzi J, Dunn RT, Afshari CA, Hamadeh HK.

Toxicol Sci · journal article · DOI 10.1093/toxsci/kft176

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2011-06-18

Metabolism of 4-Aminopiperidine Drugs by Cytochrome P450s: Molecular and Quantum Mechanical Insights into Drug Design.

Sun H, Scott DO.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/ml200117z

Bibliografisk träff 2010-09-10

Predicting phospholipidosis using machine learning.

Lowe R, Glen RC, Mitchell JB.

Mol Pharm · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/mp100103e

Bibliografisk träff 2010-09-09

Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.

Morgan RE, Trauner M, van Staden CJ, Lee PH, Ramachandran B, Eschenberg M, Afshari CA, Qualls CW, Lightfoot-Dunn R, Hamadeh HK.

Toxicol Sci · journal article · DOI 10.1093/toxsci/kfq269

Bibliografisk träff 2008-04-21

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Obach RS, Lombardo F, Waters NJ.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.108.020479

Bibliografisk träff 2008-01-01

Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.

Kruhlak NL, Choi SS, Contrera JF, Weaver JL, Willard JM, Hastings KL, Sancilio LF.

Toxicol Mech Methods · journal article · DOI 10.1080/15376510701857262

Bibliografisk träff 2007-04-12

Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential.

Pelletier DJ, Gehlhaar D, Tilloy-Ellul A, Johnson TO, Greene N.

J Chem Inf Model · journal article · DOI 10.1021/ci6004542

Bibliografisk träff 2005-07-01

Range and sensitivity as descriptors of molecular property spaces in dynamic QSAR analyses.

Vistoli G, Pedretti A, Villa L, Testa B.

J Med Chem · journal article · DOI 10.1021/jm0408969

Bibliografisk träff 2000-06-01

QSAR model for drug human oral bioavailability.

Yoshida F, Topliss JG.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0000564

Bibliografisk träff 1997-04-01

Pharmacological options in the treatment of benign prostatic hyperplasia.

Kenny B, Ballard S, Blagg J, Fox D.

J Med Chem · review; journal article · DOI 10.1021/jm960697s

Bibliografisk träff 1995-09-01

Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.

Hieble JP, Bondinell WE, Ruffolo RR.

J Med Chem · review; journal article · DOI 10.1021/jm00018a001

Bibliografisk träff 1987-02-01

Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents.

Jirkovsky I, Santroch G, Baudy R, Oshiro G.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00385a022

Bibliografisk träff 1984-12-01

Functional group contributions to drug-receptor interactions.

Andrews PR, Craik DJ, Martin JL.

J Med Chem · comparative study; journal article · DOI 10.1021/jm00378a021

Bibliografisk träff 1983-10-01

Synthesis and antihypertensive activity of a series of spiro[1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizine-2,5'-oxazolidin-2'-one]s.

Caroon JM, Clark RD, Kluge AF, Lee CH, Strosberg AM.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00364a013

Bibliografisk träff 1983-06-01

Antihypertensive 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones.

Clark RD, Caroon JM, Repke DB, Strosberg AM, Bitter SM, Okada MD, Michel AD, Whiting RL.

J Med Chem · journal article · DOI 10.1021/jm00360a013

Bibliografisk träff 1981-11-01

Synthesis and antihypertensive activity of a series of 8-substituted 1-oxa-3,8-diazaspiro[4.5]decan-2-ones.

Caroon JM, Clark RD, Kluge AF, Nelson JT, Strosberg AM, Unger SH, Michel AD, Whiting RL.

J Med Chem · journal article · DOI 10.1021/jm00143a012

Bibliografisk träff 1981-03-01

Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity.

Unger SH, Chiang GH.

J Med Chem · journal article · DOI 10.1021/jm00135a006

Bibliografisk träff 1980-08-01

Antihypertensive ureidopiperidines.

Archibald JL, Beardsley DR, Bisset GM, Fairbrother P, Jackson JL, Opalko A, Ward TJ.

J Med Chem · journal article · DOI 10.1021/jm00182a009