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Publikationer i urvalet

11 träffar

Bibliografisk träff 2022-11-08

Discovery of oxazoline enhancers of cellular progranulin release.

Peng X, Lanter JC, Y-P Chen A, Brand MA, Wozniak MK, Hoekman S, Longin O, Regeling H, Zonneveld W, P L Bell R, Koenig G, Hurst RS, Blain JF, Burnett DA.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2022.129048

Bibliografisk träff 2021-06-18

Discovery of quinuclidine modulators of cellular progranulin.

Lanter JC, Chen AY, Williamson T, Koenig G, Blain JF, Burnett DA.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2021.128209

Bibliografisk träff 2017-06-03

Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments.

Del Bello F, Bonifazi A, Giorgioni G, Petrelli R, Quaglia W, Altomare A, Falcicchio A, Matucci R, Vistoli G, Piergentili A.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.06.004

Bibliografisk träff 2016-03-03

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.

Drug Discov Today · review; journal article · DOI 10.1016/j.drudis.2016.02.015

Bibliografisk träff 2014-07-31

Prediction of Thorough QT study results using action potential simulations based on ion channel screens.

Mirams GR, Davies MR, Brough SJ, Bridgland-Taylor MH, Cui Y, Gavaghan DJ, Abi-Gerges N.

J Pharmacol Toxicol Methods · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.vascn.2014.07.002

Bibliografisk träff 2013-01-01

MICE models: superior to the HERG model in predicting Torsade de Pointes.

Kramer J, Obejero-Paz CA, Myatt G, Kuryshev YA, Bruening-Wright A, Verducci JS, Brown AM.

Sci Rep · research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/srep02100

Bibliografisk träff 2011-04-07

Species independence in brain tissue binding using brain homogenates.

Di L, Umland JP, Chang G, Huang Y, Lin Z, Scott DO, Troutman MD, Liston TE.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.111.038778

Bibliografisk träff 2010-02-01

Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.

Varma MV, Obach RS, Rotter C, Miller HR, Chang G, Steyn SJ, El-Kattan A, Troutman MD.

J Med Chem · journal article · DOI 10.1021/jm901371v

Bibliografisk träff 2009-08-01

Physicochemical determinants of human renal clearance.

Varma MV, Feng B, Obach RS, Troutman MD, Chupka J, Miller HR, El-Kattan A.

J Med Chem · journal article · DOI 10.1021/jm900403j

Bibliografisk träff 2008-04-21

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Obach RS, Lombardo F, Waters NJ.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.108.020479

Bibliografisk träff 2005-10-01

Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists.

Naito R, Yonetoku Y, Okamoto Y, Toyoshima A, Ikeda K, Takeuchi M.

J Med Chem · journal article · DOI 10.1021/jm050099q