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Publikationer i urvalet

10 träffar

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2022-10-21

Identification of Organic Anion Transporter 2 Inhibitors: Screening, Structure-Based Analysis, and Clinical Drug Interaction Risk Assessment.

Ryu S, Woody N, Chang G, Mathialagan S, Varma MVS.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.2c01079

Bibliografisk träff 2018-09-14

Methyl-containing pharmaceuticals: Methylation in drug design.

Sun S, Fu J.

Bioorg Med Chem Lett · review; journal article · DOI 10.1016/j.bmcl.2018.09.016

Bibliografisk träff 2017-08-01

Opioid Receptor Modulators with a Cinnamyl Group.

Ravilla L, Venkata Subba Naidu N, Dogra S, Umrao D, Yadav PN, Biswas A, Michael D, Sekar K, Nagarajan K.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.7b00643

Bibliografisk träff 2017-05-03

Discovery of N-substituted-endo-3-(8-aza-bicyclo[3.2.1]oct-3-yl)-phenol and -phenyl carboxamide series of μ-opioid receptor antagonists.

Jiang L, Beattie DT, Jacobsen JR, Kintz S, Obedencio GP, Saito D, Stergiades I, Vickery RG, Long DD.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2017.04.092

Bibliografisk träff 2016-03-03

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.

Chen M, Suzuki A, Thakkar S, Yu K, Hu C, Tong W.

Drug Discov Today · review; journal article · DOI 10.1016/j.drudis.2016.02.015

Bibliografisk träff 2014-07-31

Prediction of Thorough QT study results using action potential simulations based on ion channel screens.

Mirams GR, Davies MR, Brough SJ, Bridgland-Taylor MH, Cui Y, Gavaghan DJ, Abi-Gerges N.

J Pharmacol Toxicol Methods · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.vascn.2014.07.002

Bibliografisk träff 2013-08-16

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Morgan RE, van Staden CJ, Chen Y, Kalyanaraman N, Kalanzi J, Dunn RT, Afshari CA, Hamadeh HK.

Toxicol Sci · journal article · DOI 10.1093/toxsci/kft176

Bibliografisk träff 2012-11-09

Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents.

Yuan Y, Elbegdorj O, Chen J, Akubathini SK, Zhang F, Stevens DL, Beletskaya IO, Scoggins KL, Zhang Z, Gerk PM, Selley DE, Akbarali HI, Dewey WL, Zhang Y.

J Med Chem · research-article; evaluation study; journal article; research support, n.i.h., extramural · DOI 10.1021/jm301247n

Bibliografisk träff 2008-02-02

Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles.

Le Bourdonnec B, Barker WM, Belanger S, Wiant DD, Conway-James NC, Cassel JA, O'Neill TJ, Little PJ, DeHaven RN, DeHaven-Hudkins DL, Dolle RE.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.01.106