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Publikationer i urvalet

19 träffar

Bibliografisk träff 2024-03-19

Ebselen analogues with dual human neutrophil elastase (HNE) inhibitory and antiradical activity.

Crocetti L, Catarzi F, Giovannoni MP, Vergelli C, Bartolucci G, Pallecchi M, Paoli P, Rossi P, Lippi M, Schepetkin IA, Quinn MT, Guerrini G.

RSC Med Chem · research-article; journal article · DOI 10.1039/d3md00736g

Bibliografisk träff 2023-11-07

Design and synthesis of sirtinol analogs as human neutrophil elastase inhibitors.

Hwang TL, Lin JY, Kuo LM, Kumar Dhandabani G, Hsieh PW.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2023.129544

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2022-01-10

Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo Biological Evaluation for Acute Lung Injury.

Cui Y, Zhang M, Xu H, Zhang T, Zhang S, Zhao X, Jiang P, Li J, Ye B, Sun Y, Wang M, Deng Y, Meng Q, Liu Y, Fu Q, Lin J, Wang L, Chen Y.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c01583

Bibliografisk träff 2021-09-24

1,5,6,7-Tetrahydro-4H-indazol-4-ones as human neutrophil elastase (HNE) inhibitors.

Cantini N, Crocetti L, Guerrini G, Vergelli C, Schepetkin IA, Pallecchi M, Bartolucci G, Quinn MT, Teodori E, Giovannoni MP.

Bioorg Med Chem Lett · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2021.128380

Bibliografisk träff 2021-01-31

Targeting Necrosis: Elastase-like Protease Inhibitors Curtail Necrotic Cell Death Both <i>In Vitro</i> and in Three <i>In Vivo</i> Disease Models.

Khalfin B, Lichtenstein A, Albeck A, Nathan I.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.0c01683

Bibliografisk träff 2020-11-06

Exploration of nitrogen heterocycle scaffolds for the development of potent human neutrophil elastase inhibitors.

Cantini N, Khlebnikov AI, Crocetti L, Schepetkin IA, Floresta G, Guerrini G, Vergelli C, Bartolucci G, Quinn MT, Giovannoni MP.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2020.115836

Bibliografisk träff 2020-09-09

Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7.

Chen QY, Luo D, Seabra GM, Luesch H.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2020.115756

Bibliografisk träff 2020-08-07

Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?

Korkmaz B, Lesner A, Marchand-Adam S, Moss C, Jenne DE.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.0c00776

Bibliografisk träff 2018-03-04

A BODIPY-Tagged Phosphono Peptide as Activity-Based Probe for Human Leukocyte Elastase.

Schulz-Fincke AC, Blaut M, Braune A, Gütschow M.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.7b00533

Bibliografisk träff 2015-01-16

Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3.

Hwang TL, Wang WH, Wang TY, Yu HP, Hsieh PW.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2014.12.056

Bibliografisk träff 2014-08-01

Anti-Inflammatory Spirostanol and Furostanol Saponins from Solanum macaonense.

Lee CL, Hwang TL, Yang JC, Cheng HT, He WJ, Yen CT, Kuo CL, Chen CJ, Chang WY, Wu YC.

J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/np500057b

Bibliografisk träff 2013-11-20

Optimization of O3-acyl kojic acid derivatives as potent and selective human neutrophil elastase inhibitors.

Lucas SD, Gonçalves LM, Carvalho LA, Correia HF, Da Costa EM, Guedes RA, Moreira R, Guedes RC.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm4011725

Bibliografisk träff 2013-01-28

Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells.

Salvador LA, Taori K, Biggs JS, Jakoncic J, Ostrov DA, Paul VJ, Luesch H.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm3017305

Bibliografisk träff 2012-09-07

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.

Warner DJ, Chen H, Cantin LD, Kenna JG, Stahl S, Walker CL, Noeske T.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.112.047068

Bibliografisk träff 2011-07-07

Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase.

Crocetti L, Giovannoni MP, Schepetkin IA, Quinn MT, Khlebnikov AI, Cilibrizzi A, Piaz VD, Graziano A, Vergelli C.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2011.06.036

Bibliografisk träff 2011-01-22

Simple phosphonic inhibitors of human neutrophil elastase.

Sieńczyk M, Winiarski Ł, Kasperkiewicz P, Psurski M, Wietrzyk J, Oleksyszyn J.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2011.01.083

Bibliografisk träff 2002-09-01

Clarification of mechanism of human sputum elastase inhibition by a new inhibitor, ONO-5046, using electrospray ionization mass spectrometry.

Nakayama Y, Odagaki Y, Fujita S, Matsuoka S, Hamanaka N, Nakai H, Toda M.

Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(02)00393-1

Bibliografisk träff 2000-02-01

Protease inhibitors: current status and future prospects.

Leung D, Abbenante G, Fairlie DP.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/jm990412m