Sofalcone, a gastroprotective drug, covalently binds to KEAP1 to activate Nrf2 resulting in anti-colitic activity.
Kim W, Lee H, Kim S, Joo S, Jeong S, Yoo JW, Jung Y.
Eur J Pharmacol · journal article · DOI 10.1016/j.ejphar.2019.172722 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
14 träffarColon-Targeted Delivery Facilitates the Therapeutic Switching of Sofalcone, a Gastroprotective Agent, to an Anticolitic Drug via Nrf2 Activation.
Kim W, Kim S, Ju S, Lee H, Jeong S, Yoo JW, Yoon IS, Jung Y.
Mol Pharm · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.molpharmaceut.9b00664Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: potential therapeutic for preeclampsia.
Onda K, Tong S, Nakahara A, Kondo M, Monchusho H, Hirano T, Kaitu'u-Lino T, Beard S, Binder N, Tuohey L, Brownfoot F, Brownfoot F, Hannan NJ.
Hypertension · research support, non-u.s. gov't; journal article · DOI 10.1161/hypertensionaha.114.04781Quantification of sofalcone in human plasma and urine by high performance liquid chromatography-mass spectrometry.
Wang L, Song L, Jiang X.
J Pharm Biomed Anal · journal article · DOI 10.1016/j.jpba.2011.03.040Sofalcone, a gastric mucosa protective agent, increases vascular endothelial growth factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cells.
Shibuya A, Onda K, Kawahara H, Uchiyama Y, Nakayama H, Omi T, Nagaoka M, Matsui H, Hirano T.
Biochem Biophys Res Commun · journal article · DOI 10.1016/j.bbrc.2010.06.124Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori: a randomized controlled comparative trial with cimetidine, an H2-receptor antagonist.
Higuchi K, Watanabe T, Tanigawa T, Tominaga K, Fujiwara Y, Arakawa T.
J Gastroenterol Hepatol · comparative study; randomized controlled trial; journal article · DOI 10.1111/j.1440-1746.2010.06232.xSofalcone, an anti-ulcer chalcone derivative, suppresses inflammatory crosstalk between macrophages and adipocytes and adipocyte differentiation: implication of heme-oxygenase-1 induction.
Tanaka H, Nakamura S, Onda K, Tazaki T, Hirano T.
Biochem Biophys Res Commun · journal article · DOI 10.1016/j.bbrc.2009.02.086Analysis of sofalcone in human plasma by high performance liquid chromatography.
Wen A, Wang Z, Hang T, Jia Y, Zhang T, Wu Y, Gao X, Yang Z.
J Chromatogr B Analyt Technol Biomed Life Sci · journal article · DOI 10.1016/j.jchromb.2007.05.014Sofalcone, a mucoprotective agent, increases the cure rate of Helicobacter pylori infection when combined with rabeprazole, amoxicillin and clarithromycin.
Isomoto H, Furusu H, Ohnita K, Wen CY, Inoue K, Kohno S.
World J Gastroenterol · brief-report; clinical trial; randomized controlled trial; journal article · DOI 10.3748/wjg.v11.i11.1629[Sofalcone].
Fukuda Y, Shimoyama T.
Nihon Rinsho · review; journal articleSofalcone for treatment of Helicobacter pylori infection.
Fujioka T, Murakami K, Kubota T, Kodama R, Honda S, Nasu M.
J Gastroenterol · journal articleCombination therapy with clarithromycin and sofalcone for eradication of Helicobacter pylori.
Kodama R, Fujioka T, Fujiyama K, Kawasaki H, Kubota T, Nasu M.
Eur J Gastroenterol Hepatol · controlled clinical trial; clinical trial; journal articleEffect of sofalcone on tyrosylprotein sulfotransferase.
Kasinathan C, Rizwan M, Slomiany A, Slomiany BL.
Gen Pharmacol · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1016/0306-3623(94)90112-0[Effects of the anti-ulcer drug SU-88 on the gastric blood flow and the cardiovascular system (author's transl)].
Saziki R, Arai I, Isobe Y, Aihara H.
Nihon Yakurigaku Zasshi · journal article; english abstract