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Publikationer i urvalet

11 träffar

Bibliografisk träff 2010-05-01

Thousands of chemical starting points for antimalarial lead identification.

Gamo FJ, Sanz LM, Vidal J, de Cozar C, Alvarez E, Lavandera JL, Vanderwall DE, Green DV, Kumar V, Hasan S, Brown JR, Peishoff CE, Cardon LR, Garcia-Bustos JF.

Nature · research support, non-u.s. gov't; journal article · DOI 10.1038/nature09107

Bibliografisk träff 2008-06-25

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.

Plouffe D, Brinker A, McNamara C, Henson K, Kato N, Kuhen K, Nagle A, Adrián F, Matzen JT, Anderson P, Nam TG, Gray NS, Chatterjee A, Janes J, Yan SF, Trager R, Caldwell JS, Schultz PG, Zhou Y, Winzeler EA.

Proc Natl Acad Sci U S A · research support, non-u.s. gov't; research-article; journal article · DOI 10.1073/pnas.0802982105

Bibliografisk träff 2004-08-01

[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].

Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.

Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2

Bibliografisk träff 2000-04-01

Analogues of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: synthesis and in vitro antitumor activity.

Rosowsky A, Wright JE, Vaidya CM, Forsch RA, Bader H.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm990630f

Bibliografisk träff 1997-01-01

Analogues of methotrexate in rheumatoid arthritis. 1. Effects of 10-deazaaminopterin analogues on type II collagen-induced arthritis in mice.

DeGraw JI, Colwell WT, Crase J, Smith RL, Piper JR, Waud WR, Sirotnak FM.

J Med Chem · journal article · DOI 10.1021/jm9505526

Bibliografisk träff 1994-07-01

Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.

Rosowsky A, Bader H, Wright JE, Keyomarsi K, Matherly LH.

J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00040a008

Bibliografisk träff 1994-05-01

Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.

Kotake Y, Iijima A, Yoshimatsu K, Tamai N, Ozawa Y, Koyanagi N, Kitoh K, Nomura H.

J Med Chem · comparative study; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00037a012

Bibliografisk träff 1993-07-01

Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.

DeGraw JI, Colwell WT, Piper JR, Sirotnak FM.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00067a020

Bibliografisk träff 1991-01-01

Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase.

Abraham A, McGuire JJ, Galivan J, Nimec Z, Kisliuk RL, Gaumont Y, Nair MG.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00105a035

Bibliografisk träff 1990-01-01

Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.

DeGraw JI, Christie PH, Kisliuk RL, Gaumont Y, Sirotnak FM.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00163a035

Bibliografisk träff 1988-01-01

Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin.

Nair MG, Nanavati NT, Kumar P, Gaumont Y, Kisliuk RL.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00396a029