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Publikationer i urvalet

17 träffar

Bibliografisk träff 2024-02-19

Design, synthesis, <i>in vitro</i> and <i>in silico</i> evaluation of indole-based tetrazole derivatives as putative anti-breast cancer agents.

Kaur K, Verma H, Gangwar P, Dhiman M, Jaitak V.

RSC Med Chem · research-article; journal article · DOI 10.1039/d3md00730h

Bibliografisk träff 2024-01-30

Indole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies.

Zeng W, Han C, Mohammed S, Li S, Song Y, Sun F, Du Y.

RSC Med Chem · review-article; review; journal article · DOI 10.1039/d3md00677h

Bibliografisk träff 2023-07-19

A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs.

Sutherland JJ, Yonchev D, Fekete A, Urban L.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-40064-9

Bibliografisk träff 2023-07-16

Recent advance of small-molecule drugs for clinical treatment of osteoporosis: A review.

Zhang JY, Zhong YH, Chen LM, Zhuo XL, Zhao LJ, Wang YT.

Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2023.115654

Bibliografisk träff 2023-03-27

Perspective for Discovery of Small Molecule IL-6 Inhibitors through Study of Structure-Activity Relationships and Molecular Docking.

Nada H, Sivaraman A, Lu Q, Min K, Kim S, Goo JI, Choi Y, Lee K.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.2c01957

Bibliografisk träff 2021-11-23

Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens.

O'Donnell HR, Tummino TA, Bardine C, Craik CS, Shoichet BK.

J Med Chem · research-article; journal article · DOI 10.1021/acs.jmedchem.1c01547

Bibliografisk träff 2021-03-02

Small-Molecule Drug Discovery in Triple Negative Breast Cancer: Current Situation and Future Directions.

Liao M, Zhang J, Wang G, Wang L, Liu J, Ouyang L, Liu B.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.0c01180

Bibliografisk träff 2020-09-22

Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors.

Cooper L, Schafer A, Li Y, Cheng H, Medegan Fagla B, Shen Z, Nowar R, Dye K, Anantpadma M, Davey RA, Thatcher GRJ, Rong L, Xiong R.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.0c01001

Bibliografisk träff 2019-12-10

Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer.

Lu Y, Gutgesell LM, Xiong R, Zhao J, Li Y, Rosales CI, Hollas M, Shen Z, Gordon-Blake J, Dye K, Wang Y, Lee S, Chen H, He D, Dubrovyskyii O, Zhao H, Huang F, Lasek AW, Tonetti DA, Thatcher GRJ.

J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.9b01580

Bibliografisk träff 2018-04-17

Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors.

Capuzzi SJ, Sun W, Muratov EN, Martínez-Romero C, He S, Zhu W, Li H, Tawa G, Fisher EG, Xu M, Shinn P, Qiu X, García-Sastre A, Zheng W, Tropsha A.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.8b00035

Bibliografisk träff 2018-02-04

Design, synthesis and biological evaluation of novel indole-benzimidazole hybrids targeting estrogen receptor alpha (ER-α).

Singla R, Gupta KB, Upadhyay S, Dhiman M, Jaitak V.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.01.051

Bibliografisk träff 2017-12-01

Design, synthesis and biological evaluation of novel indole-xanthendione hybrids as selective estrogen receptor modulators.

Singla R, Gupta KB, Upadhyay S, Dhiman M, Jaitak V.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2017.11.040

Bibliografisk träff 2016-01-29

The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts.

Korade Z, Kim HY, Tallman KA, Liu W, Koczok K, Balogh I, Xu L, Mirnics K, Porter NA.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.5b01696

Bibliografisk träff 2014-01-31

Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface.

Li H, Xiao H, Lin L, Jou D, Kumari V, Lin J, Li C.

J Med Chem · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm401144z

Bibliografisk träff 2012-06-08

Quantitative prediction of human intestinal glucuronidation effects on intestinal availability of UDP-glucuronosyltransferase substrates using in vitro data.

Nakamori F, Naritomi Y, Hosoya K, Moriguchi H, Tetsuka K, Furukawa T, Kadono K, Yamano K, Terashita S, Teramura T.

Drug Metab Dispos · research support, non-u.s. gov't; journal article · DOI 10.1124/dmd.112.045476

Bibliografisk träff 2005-10-03

Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms.

Blizzard TA, Morgan JD, Chan W, Birzin ET, Pai LY, Hayes EC, DaSilva CA, Mosley RT, Yang YT, Rohrer SP, Dininno F, Hammond ML.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2005.08.084

Bibliografisk träff 2001-05-01

Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens.

Miller CP, Collini MD, Tran BD, Harris HA, Kharode YP, Marzolf JT, Moran RA, Henderson RA, Bender RH, Unwalla RJ, Greenberger LM, Yardley JP, Abou-Gharbia MA, Lyttle CR, Komm BS.

J Med Chem · journal article · DOI 10.1021/jm010086m