2-Phenylcyclopropylmethylamine (PCPMA) as a privileged scaffold for central nervous system drug design.
Li H, Cheng J.
Bioorg Med Chem Lett · research support, non-u.s. gov't; review; journal article · DOI 10.1016/j.bmcl.2024.129654 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
8 träffarExcretion and metabolism of milnacipran in humans after oral administration of milnacipran hydrochloride.
Li F, Chin C, Wangsa J, Ho J.
Drug Metab Dispos · clinical trial; research support, non-u.s. gov't; journal article · DOI 10.1124/dmd.112.045120Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors.
Vickers T, Dyck B, Tamiya J, Zhang M, Jovic F, Grey J, Fleck BA, Aparicio A, Johns M, Jin L, Tang H, Foster AC, Chen C.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.04.045Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors.
Tamiya J, Dyck B, Zhang M, Phan K, Fleck BA, Aparicio A, Jovic F, Tran JA, Vickers T, Grey J, Foster AC, Chen C.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.04.025A method for designing conformationally restricted analogues based on allylic strain: synthesis of a novel class of noncompetitive NMDA receptor antagonists having the acrylamide structure.
Ohmori Y, Yamashita A, Tsujita R, Yamamoto T, Taniuchi K, Matsuda A, Shuto S.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm030226nSynthesis and biological activity of conformationally restricted analogues of milnacipran: (1S, 2R)-1-phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide is a novel class of NMDA receptor channel blocker.
Shuto S, Ono S, Imoto H, Yoshii K, Matsuda A.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm980238mSynthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxami de, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist.
Shuto S, Ono S, Hase Y, Ueno Y, Noguchi T, Yoshii K, Matsuda A.
J Med Chem · journal article · DOI 10.1021/jm960495w(+/-)-(Z)-2-(aminomethyl)-1-phenylcyclopropanecarboxamide derivatives as a new prototype of NMDA receptor antagonists.
Shuto S, Takada H, Mochizuki D, Tsujita R, Hase Y, Ono S, Shibuya N, Matsuda A.
J Med Chem · journal article · DOI 10.1021/jm00015a019