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Publikationer i urvalet

22 träffar

Bibliografisk träff 2020-05-18

Antimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy.

Blank BR, Gonciarz RL, Talukder P, Gut J, Legac J, Rosenthal PJ, Renslo AR.

ACS Infect Dis · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acsinfecdis.0c00064

Bibliografisk träff 2020-04-19

A novel hydrophilic interaction liquid chromatography method for the analysis of arterolane; Isolation and structural elucidation of its major degradation product by LC-HRMS and NMR.

Niguram P, Goswami A, Kate AS.

J Pharm Biomed Anal · journal article · DOI 10.1016/j.jpba.2020.113279

Bibliografisk träff 2018-02-23

Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity.

Giannangelo C, Stingelin L, Yang T, Tilley L, Charman SA, Creek DJ.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.01566-17

Bibliografisk träff 2017-04-11

Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro.

Straimer J, Gnädig NF, Stokes BH, Ehrenberger M, Crane AA, Fidock DA.

mBio · research-article; journal article · DOI 10.1128/mbio.00172-17

Bibliografisk träff 2017-01-25

In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate.

Baumgärtner F, Jourdan J, Scheurer C, Blasco B, Campo B, Mäser P, Wittlin S.

Malar J · research-article; journal article · DOI 10.1186/s12936-017-1696-0

Bibliografisk träff 2017-01-18

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).

Dong Y, Wang X, Kamaraj S, Bulbule VJ, Chiu FC, Chollet J, Dhanasekaran M, Hein CD, Papastogiannidis P, Morizzi J, Shackleford DM, Barker H, Ryan E, Scheurer C, Tang Y, Zhao Q, Zhou L, White KL, Urwyler H, Charman WN, Matile H, Wittlin S, Charman SA, Vennerstrom JL.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.6b01586

Bibliografisk träff 2016-07-22

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains.

Yang T, Xie SC, Cao P, Giannangelo C, McCaw J, Creek DJ, Charman SA, Klonis N, Tilley L.

Antimicrob Agents Chemother · research-article; journal article · DOI 10.1128/aac.00574-16

Bibliografisk träff 2015-09-28

Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel).

Jourdan J, Matile H, Reift E, Biehlmaier O, Dong Y, Wang X, Mäser P, Vennerstrom JL, Wittlin S.

ACS Infect Dis · research-article; journal article · DOI 10.1021/acsinfecdis.5b00090

Bibliografisk träff 2014-12-19

Efficacy of Synriam™, a new antimalarial combination of OZ277 and piperaquine, against different developmental stages of Schistosoma mansoni.

Mossallam SF, Amer EI, El-Faham MH.

Acta Trop · journal article · DOI 10.1016/j.actatropica.2014.12.005

Bibliografisk träff 2014-07-21

Ex vivo activity of endoperoxide antimalarials, including artemisone and arterolane, against multidrug-resistant Plasmodium falciparum isolates from Cambodia.

Lanteri CA, Chaorattanakawee S, Lon C, Saunders DL, Rutvisuttinunt W, Yingyuen K, Bathurst I, Ding XC, Tyner SD.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.02462-14

Bibliografisk träff 2014-07-01

Fixed dose combination of arterolane and piperaquine: a newer prospect in antimalarial therapy.

Patil C, Katare S, Baig M, Doifode S.

Ann Med Health Sci Res · review-article; review; journal article · DOI 10.4103/2141-9248.139270

Bibliografisk träff 2013-12-17

Safety, tolerability and pharmacokinetic profile of single and multiple oral doses of arterolane (RBx11160) maleate in healthy subjects.

Saha N, Moehrle JJ, Zutshi A, Sharma P, Kaur P, Iyer SS.

J Clin Pharmacol · research support, non-u.s. gov't; clinical trial, phase i; randomized controlled trial; journal article · DOI 10.1002/jcph.232

Bibliografisk träff 2013-03-15

Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.

Wang X, Dong Y, Wittlin S, Charman SA, Chiu FC, Chollet J, Katneni K, Mannila J, Morizzi J, Ryan E, Scheurer C, Steuten J, Santo Tomas J, Snyder C, Vennerstrom JL.

J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm400004u

Bibliografisk träff 2013-01-31

In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains.

Abiodun OO, Brun R, Wittlin S.

Malar J · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/1475-2875-12-43

Bibliografisk träff 2010-01-01

The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).

Dong Y, Wittlin S, Sriraghavan K, Chollet J, Charman SA, Charman WN, Scheurer C, Urwyler H, Santo Tomas J, Snyder C, Creek DJ, Morizzi J, Koltun M, Matile H, Wang X, Padmanilayam M, Tang Y, Dorn A, Brun R, Vennerstrom JL.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm901473s

Bibliografisk träff 2010-01-01

Development and validation of a headspace gas chromatographic method for the determination of residual solvents in arterolane (RBx11160) maleate bulk drug.

Gupta A, Singh Y, Srinivas KS, Jain G, Sreekumar VB, Semwal VP.

J Pharm Bioallied Sci · research-article; journal article · DOI 10.4103/0975-7406.62706

Bibliografisk träff 2009-12-22

Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals.

Fügi MA, Wittlin S, Dong Y, Vennerstrom JL.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.01305-09

Bibliografisk träff 2009-07-17

Simultaneous determination of OZ277, a synthetic 1,2,4-trioxolane antimalarial, and its polar metabolites in rat plasma using hydrophilic interaction chromatography.

Bhamidipati RK, Morizzi J, Chiu FC, Shackleford DM, Charman SA.

J Chromatogr B Analyt Technol Biomed Life Sci · research support, non-u.s. gov't; journal article · DOI 10.1016/j.jchromb.2009.07.015

Bibliografisk träff 2007-06-11

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

Kaiser M, Wittlin S, Nehrbass-Stuedli A, Dong Y, Wang X, Hemphill A, Matile H, Brun R, Vennerstrom JL.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00225-07

Bibliografisk träff 2006-12-04

Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).

Uhlemann AC, Wittlin S, Matile H, Bustamante LY, Krishna S.

Antimicrob Agents Chemother · comparative study; research-article; journal article · DOI 10.1128/aac.01064-06

Bibliografisk träff 2006-11-07

In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.

Snyder C, Chollet J, Santo-Tomas J, Scheurer C, Wittlin S.

Exp Parasitol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.exppara.2006.09.016

Bibliografisk träff 2004-08-01

Identification of an antimalarial synthetic trioxolane drug development candidate.

Vennerstrom JL, Arbe-Barnes S, Brun R, Charman SA, Chiu FC, Chollet J, Dong Y, Dorn A, Hunziker D, Matile H, McIntosh K, Padmanilayam M, Santo Tomas J, Scheurer C, Scorneaux B, Tang Y, Urwyler H, Wittlin S, Charman WN.

Nature · research support, non-u.s. gov't; journal article · DOI 10.1038/nature02779

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Publikationer i urvalet

Antimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy.

A novel hydrophilic interaction liquid chromatography method for the analysis of arterolane; Isolation and structural elucidation of its major degradation product by LC-HRMS and NMR.

Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts <i>In Vitro</i> Antimalarial Activity.

<i>Plasmodium falciparum</i> K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness <i>In Vitro</i>.

In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate.

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains.

Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel).

Efficacy of Synriam™, a new antimalarial combination of OZ277 and piperaquine, against different developmental stages of Schistosoma mansoni.

Ex vivo activity of endoperoxide antimalarials, including artemisone and arterolane, against multidrug-resistant Plasmodium falciparum isolates from Cambodia.

Fixed dose combination of arterolane and piperaquine: a newer prospect in antimalarial therapy.

Safety, tolerability and pharmacokinetic profile of single and multiple oral doses of arterolane (RBx11160) maleate in healthy subjects.

Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.

In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains.

The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).

Development and validation of a headspace gas chromatographic method for the determination of residual solvents in arterolane (RBx11160) maleate bulk drug.

Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals.

Simultaneous determination of OZ277, a synthetic 1,2,4-trioxolane antimalarial, and its polar metabolites in rat plasma using hydrophilic interaction chromatography.

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).

In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.

Identification of an antimalarial synthetic trioxolane drug development candidate.