The BET Inhibitor JQ1 Potentiates the Anticlonogenic Effect of Radiation in Pancreatic Cancer Cells.
Garcia PL, Miller AL, Zeng L, van Waardenburg RCAM, Yang ES, Yoon KJ.
Front Oncol · brief-report; journal article · DOI 10.3389/fonc.2022.925718 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
51 träffarSynergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer.
Yellapu NK, Ly T, Sardiu ME, Pei D, Welch DR, Thompson JA, Koestler DC.
BMC Cancer · research-article; journal article · DOI 10.1186/s12885-022-09690-2BET inhibitor JQ1 enhances anti-tumor immunity and synergizes with PD-1 blockade in CRC.
Wang H, Liu G, Jin X, Song S, Chen S, Zhou P, Li H, Liang J, Li B, Zhang C, He Y.
J Cancer · research-article; journal article · DOI 10.7150/jca.69375Bromodomain Inhibitor JQ1 Provides Novel Insights and Perspectives in Rhabdomyosarcoma Treatment.
Marchesi I, Fais M, Fiorentino FP, Bordoni V, Sanna L, Zoroddu S, Bagella L.
Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms23073581Evaluation of JQ1 Combined With Docetaxel for the Treatment of Prostate Cancer Cells in 2D- and 3D-Culture Systems.
Xu Y, Pachnikova G, Przybilla D, Schäfer R, Cui Y, Zhou D, Chen Z, Zhao A, Keilholz U.
Front Pharmacol · research-article; journal article · DOI 10.3389/fphar.2022.839620Colorectal cancer inhibition by BET inhibitor JQ1 is MYC-independent and not improved by nanoencapsulation.
Fourniols T, Maggio V, Rafael D, Colaco A, Vidal EG, Lopes A, Schwartz S, Martínez-Barriocanal Á, Preat V, Arango D.
Eur J Pharm Biopharm · journal article · DOI 10.1016/j.ejpb.2021.10.017JQ1 attenuates psychostimulant- but not opioid-induced conditioned place preference.
Babigian CJ, Wiedner HJ, Wahlestedt C, Sartor GC.
Behav Brain Res · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bbr.2021.113644The BET Inhibitor JQ1 Augments the Antitumor Efficacy of Gemcitabine in Preclinical Models of Pancreatic Cancer.
Miller AL, Garcia PL, Fehling SC, Gamblin TL, Vance RB, Council LN, Chen D, Yang ES, van Waardenburg RCAM, Yoon KJ.
Cancers (Basel) · research-article; journal article · DOI 10.3390/cancers13143470The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis.
Go S, Kang M, Kwon SP, Jung M, Jeon OH, Kim BS.
Tissue Eng Regen Med · research support, non-u.s. gov't; research-article; journal article · DOI 10.1007/s13770-021-00346-zTargeting MYC as a Therapeutic Intervention for Anaplastic Thyroid Cancer.
Enomoto K, Zhu X, Park S, Zhao L, Zhu YJ, Willingham MC, Qi J, Copland JA, Meltzer P, Cheng SY.
J Clin Endocrinol Metab · research support, n.i.h., intramural; research-article; journal article · DOI 10.1210/jc.2016-3771Ubenimex enhances Brd4 inhibition by suppressing HEXIM1 autophagic degradation and suppressing the Akt pathway in glioma cells.
Han L, Zhao Q, Liang X, Wang X, Zhang Z, Ma Z, Zhao M, Wang A, Liu S.
Oncotarget · research-article; journal article · DOI 10.18632/oncotarget.17314Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors.
Lines KE, Stevenson M, Filippakopoulos P, Müller S, Lockstone HE, Wright B, Grozinsky-Glasberg S, Grossman AB, Knapp S, Buck D, Bountra C, Thakker RV.
Oncogenesis · research-article; journal article · DOI 10.1038/oncsis.2017.30Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1.
Decker TM, Kluge M, Krebs S, Shah N, Blum H, Friedel CC, Eick D.
Sci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41598-017-01943-6The effect of Ingenol-B on the suppressive capacity of elite suppressor HIV-specific CD8+ T cells.
Kwaa AK, Goldsborough K, Walker-Sperling VE, Pianowski LF, Gama L, Blankson JN.
PLoS One · research-article; journal article · DOI 10.1371/journal.pone.0174516BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma.
Ishida CT, Bianchetti E, Shu C, Halatsch ME, Westhoff MA, Karpel-Massler G, Siegelin MD.
Oncotarget · research-article; journal article · DOI 10.18632/oncotarget.16365BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure.
Duan Q, McMahon S, Anand P, Shah H, Thomas S, Salunga HT, Huang Y, Zhang R, Sahadevan A, Lemieux ME, Brown JD, Srivastava D, Bradner JE, McKinsey TA, Haldar SM.
Sci Transl Med · research-article; journal article; research support, n.i.h., extramural · DOI 10.1126/scitranslmed.aah5084The BET Bromodomain Inhibitor JQ1 Suppresses Chondrosarcoma Cell Growth via Regulation of YAP/p21/c-Myc Signaling.
Zhang HT, Gui T, Sang Y, Yang J, Li YH, Liang GH, Li T, He QY, Zha ZG.
J Cell Biochem · journal article · DOI 10.1002/jcb.25863Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts.
Bian B, Bigonnet M, Gayet O, Loncle C, Maignan A, Gilabert M, Moutardier V, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Ouaissi M, Secq V, Poizat F, Nicolle R, Blum Y, Marisa L, Rubis M, Raoul JL, Bradner JE, Qi J, Lomberk G, Urrutia R, Saul A, Dusetti N, Iovanna J.
EMBO Mol Med · research support, non-u.s. gov't; research-article; journal article · DOI 10.15252/emmm.201606975BET proteins are a key component of immunoglobulin gene expression.
Shim JM, Lee JS, Russell KE, Wiegman CH, Barnes PJ, Fear D, Adcock IM, Durham AL.
Epigenomics · research-article; journal article · DOI 10.2217/epi-2016-0147Epigenetic intervention with a BET inhibitor ameliorates acute retinal ganglion cell death in mice.
Li J, Zhao L, Urabe G, Fu Y, Guo LW.
Mol Vis · research-article; journal article; research support, n.i.h., extramuralPD-L1 Is a Therapeutic Target of the Bromodomain Inhibitor JQ1 and, Combined with HLA Class I, a Promising Prognostic Biomarker in Neuroblastoma.
Melaiu O, Mina M, Chierici M, Boldrini R, Jurman G, Romania P, D'Alicandro V, Benedetti MC, Castellano A, Liu T, Furlanello C, Locatelli F, Fruci D.
Clin Cancer Res · journal article · DOI 10.1158/1078-0432.ccr-16-2601Altered regulation and expression of genes by BET family of proteins in COPD patients.
Malhotra R, Kurian N, Zhou XH, Jiang F, Monkley S, DeMicco A, Clausen IG, Dellgren, Edenro G, Ahdesmäki MJ, Clausen M, Öberg L, Israelsson E, Belfield G, Vaarala O.
PLoS One · research-article; journal article · DOI 10.1371/journal.pone.0173115Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer.
Leal AS, Williams CR, Royce DB, Pioli PA, Sporn MB, Liby KT.
Cancer Lett · journal article · DOI 10.1016/j.canlet.2017.02.021Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy.
Xu B, Lefringhouse J, Liu Z, West D, Baldwin LA, Ou C, Chen L, Napier D, Chaiswing L, Brewer LD, St Clair D, Thibault O, van Nagell JR, Zhou BP, Drapkin R, Huang JA, Lu ML, Ueland FR, Yang XH.
Oncogenesis · research-article; journal article · DOI 10.1038/oncsis.2016.86The BET bromodomain inhibitor JQ1 radiosensitizes non-small cell lung cancer cells by upregulating p21.
Wang J, Wang Y, Mei H, Yin Z, Geng Y, Zhang T, Wu G, Lin Z.
Cancer Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.canlet.2017.01.031Targeting AMPK-ULK1-mediated autophagy for combating BET inhibitor resistance in acute myeloid leukemia stem cells.
Jang JE, Eom JI, Jeung HK, Cheong JW, Lee JY, Kim JS, Min YH.
Autophagy · article-commentary; journal article · DOI 10.1080/15548627.2016.1278328BET-Inhibitors Disrupt Rad21-Dependent Conformational Control of KSHV Latency.
Chen HS, De Leo A, Wang Z, Kerekovic A, Hills R, Lieberman PM.
PLoS Pathog · research-article; journal article · DOI 10.1371/journal.ppat.1006100Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc.
Aird F, Kandela I, Mantis C, Reproducibility Project: Cancer Biology.
Elife · research-article; journal article · DOI 10.7554/elife.21253Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration.
Zhao L, Li J, Fu Y, Zhang M, Wang B, Ouellette J, Shahi PK, Pattnaik BR, Watters JJ, Wong WT, Guo LW.
J Neuroinflammation · research-article; journal article; research support, n.i.h., extramural · DOI 10.1186/s12974-016-0775-4Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression.
Zhou B, Mu J, Gong Y, Lu C, Zhao Y, He T, Qin Z.
Redox Biol · research-article; journal article · DOI 10.1016/j.redox.2016.12.031