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Publikationer i urvalet

38 träffar

Bibliografisk träff 2018-12-01

Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61.

Calcaterra A, Iovine V, Botta B, Quaglio D, D'Acquarica I, Ciogli A, Iazzetti A, Alfonsi R, Lospinoso Severini L, Infante P, Di Marcotullio L, Mori M, Ghirga F.

J Enzyme Inhib Med Chem · research-article; journal article · DOI 10.1080/14756366.2017.1419221

Bibliografisk träff 2018-04-24

Hedgehog signaling negatively co-regulates BH3-only protein Noxa and TAp73 in TP53-mutated cells.

Meister MT, Boedicker C, Klingebiel T, Fulda S.

Cancer Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.canlet.2018.04.025

Bibliografisk träff 2018-04-06

Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture.

Usui T, Sakurai M, Umata K, Elbadawy M, Ohama T, Yamawaki H, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, Sato K, Kaneda M, Sasaki K.

Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms19041098

Bibliografisk träff 2018-01-13

The protective autophagy activated by GANT-61 in MYCN amplified neuroblastoma cells is mediated by PERK.

Wang J, Huang S, Tian R, Chen J, Gao H, Xie C, Shan Y, Zhang Z, Gu S, Xu M.

Oncotarget · research-article; journal article · DOI 10.18632/oncotarget.24214

Bibliografisk träff 2018-01-08

Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer.

Riaz SK, Khan JS, Shah STA, Wang F, Ye L, Jiang WG, Malik MFA.

Cell Commun Signal · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/s12964-017-0213-y

Bibliografisk träff 2018-01-05

GANT-61 and GDC-0449 induce apoptosis of prostate cancer stem cells through a GLI-dependent mechanism.

Tong W, Qiu L, Qi M, Liu J, Hu K, Lin W, Huang Y, Fu J.

J Cell Biochem · research support, non-u.s. gov't; journal article · DOI 10.1002/jcb.26572

Bibliografisk träff 2018-01-03

Inhibition of Gli leads to antitumor growth and enhancement of cisplatin-induced cytotoxicity in large cell neuroendocrine carcinoma of the lung.

Ishiwata T, Iwasawa S, Ebata T, Fan M, Tada Y, Tatsumi K, Takiguchi Y.

Oncol Rep · journal article · DOI 10.3892/or.2018.6183

Bibliografisk träff 2017-10-23

Inhibition of Gli1-mediated prostate cancer cell proliferation by inhibiting the mTOR/S6K1 signaling pathway.

Yang H, Hu L, Liu Z, Qin Y, Li R, Zhang G, Zhao B, Bi C, Lei Y, Bai Y.

Oncol Lett · research-article; journal article · DOI 10.3892/ol.2017.7254

Bibliografisk träff 2017-09-28

Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.

Oladapo HO, Tarpley M, Sauer SJ, Addo KA, Ingram SM, Strepay D, Ehe BK, Chdid L, Trinkler M, Roques JR, Darr DB, Fleming JM, Devi GR, Williams KP.

Cancer Lett · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.canlet.2017.09.033

Bibliografisk träff 2017-09-01

Hedgehog signaling inhibitor GANT61 induces endoplasmic reticulum stress-mediated protective autophagy in hepatic stellate cells.

Li J, Zhang L, Xia Q, Fu J, Zhou Z, Lin F.

Biochem Biophys Res Commun · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbrc.2017.08.164

Bibliografisk träff 2017-07-01

GLI1 inhibitor GANT61 exhibits antitumor efficacy in T-cell lymphoma cells through down-regulation of p-STAT3 and SOCS3.

Geng L, Lu K, Li P, Li X, Zhou X, Li Y, Wang X.

Oncotarget · research-article; journal article · DOI 10.18632/oncotarget.9792

Bibliografisk träff 2017-04-27

Anti-cancer stem cell activity of a hedgehog inhibitor GANT61 in estrogen receptor-positive breast cancer cells.

Kurebayashi J, Koike Y, Ohta Y, Saitoh W, Yamashita T, Kanomata N, Moriya T.

Cancer Sci · research-article; journal article · DOI 10.1111/cas.13205

Bibliografisk träff 2017-04-27

Gli1<sup>+</sup> Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.

Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R.

Cell Stem Cell · research-article; journal article · DOI 10.1016/j.stem.2017.03.008

Bibliografisk träff 2017-04-01

[Effect of Hedgehog Signaling Pathway Abnormality on Chemothe-rapeutic Resistance of Multiple Myeloma].

Hu JS, Huang X, Huang YD, Lu YY, Lu QY.

Zhongguo Shi Yan Xue Ye Xue Za Zhi · journal article · DOI 10.7534/j.issn.1009-2137.2017.02.028

Bibliografisk träff 2017-02-13

The Effect of Metformin and GANT61 Combinations on the Radiosensitivity of Prostate Cancer Cells.

Gonnissen A, Isebaert S, McKee CM, Muschel RJ, Haustermans K.

Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms18020399

Bibliografisk träff 2017-01-31

Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells.

Koike Y, Ohta Y, Saitoh W, Yamashita T, Kanomata N, Moriya T, Kurebayashi J.

Breast Cancer · journal article · DOI 10.1007/s12282-017-0757-0

Bibliografisk träff 2017-01-21

Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene.

Masetti R, Bertuccio SN, Astolfi A, Chiarini F, Lonetti A, Indio V, De Luca M, Bandini J, Serravalle S, Franzoni M, Pigazzi M, Martelli AM, Basso G, Locatelli F, Pession A.

J Hematol Oncol · letter; journal article · DOI 10.1186/s13045-017-0396-0

Bibliografisk träff 2016-12-13

Inhibition of the CyclinD1 promoter in response to sonic hedgehog signaling pathway transduction is mediated by Gli1.

Lin Z, Sheng H, You C, Cai M, Zhang Y, Yu LS, Yu X, Lin J, Zhang N.

Exp Ther Med · research-article; journal article · DOI 10.3892/etm.2016.3969

Bibliografisk träff 2016-12-01

The hedgehog inhibitor GANT61 sensitizes prostate cancer cells to ionizing radiation both in vitro and in vivo.

Gonnissen A, Isebaert S, McKee CM, Dok R, Haustermans K, Muschel RJ.

Oncotarget · research-article; journal article · DOI 10.18632/oncotarget.12483

Bibliografisk träff 2016-12-01

Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing.

Zhang R, Wu J, Ferrandon S, Glowacki KJ, Houghton JA.

Oncotarget · research-article; journal article · DOI 10.18632/oncotarget.13376

Bibliografisk träff 2016-11-28

GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment.

Li J, Cai J, Zhao S, Yao K, Sun Y, Li Y, Chen L, Li R, Zhai X, Zhang J, Jiang C.

J Exp Clin Cancer Res · research-article; journal article · DOI 10.1186/s13046-016-0463-3

Bibliografisk träff 2016-10-28

The transcription factor GLI2 as a downstream mediator of transforming growth factor-β-induced fibroblast activation in SSc.

Liang R, Šumová B, Cordazzo C, Mallano T, Zhang Y, Wohlfahrt T, Dees C, Ramming A, Krasowska D, Michalska-Jakubus M, Distler O, Schett G, Šenolt L, Distler JH.

Ann Rheum Dis · journal article · DOI 10.1136/annrheumdis-2016-209698

Bibliografisk träff 2016-09-23

Potential role of Shh-Gli1-BMI1 signaling pathway nexus in glioma chemoresistance.

Shahi MH, Farheen S, Mariyath MP, Castresana JS.

Tumour Biol · journal article · DOI 10.1007/s13277-016-5365-7

Bibliografisk träff 2016-09-06

Suppression of GLI sensitizes medulloblastoma cells to mitochondria-mediated apoptosis.

Lin Z, Li S, Sheng H, Cai M, Ma LY, Hu L, Xu S, Yu LS, Zhang N.

J Cancer Res Clin Oncol · research-article; journal article · DOI 10.1007/s00432-016-2241-1

Bibliografisk träff 2016-07-01

GLI inhibitor GANT61 kills melanoma cells and acts in synergy with obatoclax.

Vlčková K, Réda J, Ondrušová L, Krayem M, Ghanem G, Vachtenheim J.

Int J Oncol · journal article · DOI 10.3892/ijo.2016.3596

Bibliografisk träff 2016-06-27

Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition.

Miyazaki Y, Matsubara S, Ding Q, Tsukasa K, Yoshimitsu M, Kosai K, Takao S.

Mol Cancer · research-article; journal article · DOI 10.1186/s12943-016-0534-2

Bibliografisk träff 2016-02-01

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.

Benvenuto M, Masuelli L, De Smaele E, Fantini M, Mattera R, Cucchi D, Bonanno E, Di Stefano E, Frajese GV, Orlandi A, Screpanti I, Gulino A, Modesti A, Bei R.

Oncotarget · research support, non-u.s. gov't; research-article; journal article · DOI 10.18632/oncotarget.7062

Bibliografisk träff 2015-01-01

Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis.

Lim CB, Prêle CM, Baltic S, Arthur PG, Creaney J, Watkins DN, Thompson PJ, Mutsaers SE.

Oncotarget · research support, non-u.s. gov't; research-article; journal article · DOI 10.18632/oncotarget.2729

Bibliografisk träff 2014-12-01

GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis.

Srivastava RK, Kaylani SZ, Edrees N, Li C, Talwelkar SS, Xu J, Palle K, Pressey JG, Athar M.

Oncotarget · research support, non-u.s. gov't; research-article; journal article · DOI 10.18632/oncotarget.2569

Bibliografisk träff 2014-10-17

Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells.

Wang J, Gu S, Huang J, Chen S, Zhang Z, Xu M.

BMC Cancer · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/1471-2407-14-768