In silico repurposing the Rac1 inhibitor NSC23766 for treating PTTG1-high expressing clear cell renal carcinoma.
Hsieh YY, Liu TP, Yang PM.
Pathol Res Pract · journal article · DOI 10.1016/j.prp.2019.03.002 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
17 träffarRac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4.
Mills SC, Howell L, Beekman A, Stokes L, Mueller A.
Cell Signal · journal article · DOI 10.1016/j.cellsig.2017.10.006NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model.
Veluthakal R, Sidarala V, Kowluru A.
Cell Physiol Biochem · research-article; journal article · DOI 10.1159/000445666Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864.
Wang Y, Kunit T, Ciotkowska A, Rutz B, Schreiber A, Strittmatter F, Waidelich R, Liu C, Stief CG, Gratzke C, Hennenberg M.
Br J Pharmacol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1111/bph.13099Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets.
Dütting S, Heidenreich J, Cherpokova D, Amin E, Zhang SC, Ahmadian MR, Brakebusch C, Nieswandt B.
J Thromb Haemost · research support, non-u.s. gov't; journal article · DOI 10.1111/jth.12861The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function.
Hou H, Chávez AE, Wang CC, Yang H, Gu H, Siddoway BA, Hall BJ, Castillo PE, Xia H.
J Neurosci · brief-report; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1523/jneurosci.1659-14.2014Programmed Application of Transforming Growth Factor β3 and Rac1 Inhibitor NSC23766 Committed Hyaline Cartilage Differentiation of Adipose-Derived Stem Cells for Osteochondral Defect Repair.
Zhu S, Chen P, Wu Y, Xiong S, Sun H, Xia Q, Shi L, Liu H, Ouyang HW.
Stem Cells Transl Med · research support, non-u.s. gov't; research-article; journal article · DOI 10.5966/sctm.2014-0042Delayed treatment with NSC23766 in streptozotocin-induced diabetic rats ameliorates post-ischemic neuronal apoptosis through suppression of mitochondrial p53 translocation.
Liao J, Ye Z, Huang G, Xu C, Guo Q, Wang E.
Neuropharmacology · research support, non-u.s. gov't; journal article · DOI 10.1016/j.neuropharm.2014.06.008The Rac1 inhibitor NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity.
Dierkes R, Warnking K, Liedmann S, Seyer R, Ludwig S, Ehrhardt C.
PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0088520Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo.
Zhu S, Lu P, Liu H, Chen P, Wu Y, Wang Y, Sun H, Zhang X, Xia Q, Heng BC, Zhou Y, Ouyang HW.
Ann Rheum Dis · research support, non-u.s. gov't; research-article; journal article · DOI 10.1136/annrheumdis-2013-203901NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors.
Levay M, Krobert KA, Wittig K, Voigt N, Bermudez M, Wolber G, Dobrev D, Levy FO, Wieland T.
J Pharmacol Exp Ther · research support, non-u.s. gov't; journal article · DOI 10.1124/jpet.113.207266Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice.
Yao HY, Chen L, Xu C, Wang J, Chen J, Xie QM, Wu X, Yan XF.
Biochim Biophys Acta · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbagen.2011.03.020Blockade of Rac1 activity induces G1 cell cycle arrest or apoptosis in breast cancer cells through downregulation of cyclin D1, survivin, and X-linked inhibitor of apoptosis protein.
Yoshida T, Zhang Y, Rivera Rosado LA, Chen J, Khan T, Moon SY, Zhang B.
Mol Cancer Ther · journal article · DOI 10.1158/1535-7163.mct-09-0906Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766.
Milsom MD, Lee AW, Zheng Y, Cancelas JA.
Haematologica · research support, non-u.s. gov't; research-article; journal article · DOI 10.3324/haematol.2008.004077Neuropathic pain memory is maintained by Rac1-regulated dendritic spine remodeling after spinal cord injury.
Tan AM, Stamboulian S, Chang YW, Zhao P, Hains AB, Waxman SG, Hains BC.
J Neurosci · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1523/jneurosci.3142-08.2008The Rac1 inhibitor, NSC23766, depolarizes adhesive secretion, endomembrane cycling, and tip growth in the fucoid alga, Silvetia compressa.
Hable WE, Reddy S, Julien L.
Planta · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1007/s00425-007-0673-1Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.
Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y.
Proc Natl Acad Sci U S A · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1073/pnas.0307512101