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Publikationer i urvalet

11 träffar

Bibliografisk träff 2020-04-14

RX-3117 (Fluorocyclopentenyl-Cytosine)-Mediated Down-Regulation of DNA Methyltransferase 1 Leads to Protein Expression of Tumor-Suppressor Genes and Increased Functionality of the Proton-Coupled Folate Carrier.

Sarkisjan D, Julsing JR, El Hassouni B, Honeywell RJ, Kathmann I, Matherly LH, Lee YB, Kim DJ, Peters GJ.

Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms21082717

Bibliografisk träff 2019-07-01

Uridine Cytidine Kinase 2 as a Potential Biomarker for Treatment with RX-3117 in Pancreatic Cancer.

El Hassouni B, Infante J, Mantini G, Ricci C, Funel N, Giovannetti E, Peters GJ.

Anticancer Res · journal article · DOI 10.21873/anticanres.13508

Bibliografisk träff 2019-03-16

RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment.

Balboni B, El Hassouni B, Honeywell RJ, Sarkisjan D, Giovannetti E, Poore J, Heaton C, Peterson C, Benaim E, Lee YB, Kim DJ, Peters GJ.

Expert Opin Investig Drugs · comparative study; review; journal article · DOI 10.1080/13543784.2019.1583742

Bibliografisk träff 2018-01-01

DNA methyltransferases expression in normal tissues and various human cancer cell lines, xenografts and tumors.

Honeywell RJ, Sarkisjan D, Kristensen MH, de Klerk DJ, Peters GJ.

Nucleosides Nucleotides Nucleic Acids · journal article · DOI 10.1080/15257770.2018.1498516

Bibliografisk träff 2016-12-01

The radiosensitizing effect of fluorocyclopentenyl-cytosine (RX-3117) in ovarian and lung cancer cell lines.

Sarkisjan D, van den Berg J, Smit E, Lee YB, Kim DJ, Peters GJ.

Nucleosides Nucleotides Nucleic Acids · journal article · DOI 10.1080/15257770.2016.1216565

Bibliografisk träff 2016-12-01

Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA.

Honeywell RJ, Sarkisjan D, Kathmann I, Kristensen MH, Peters GJ.

Nucleosides Nucleotides Nucleic Acids · journal article · DOI 10.1080/15257770.2016.1216566

Bibliografisk träff 2016-09-09

The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2.

Sarkisjan D, Julsing JR, Smid K, de Klerk D, van Kuilenburg AB, Meinsma R, Lee YB, Kim DJ, Peters GJ.

PLoS One · research-article; journal article · DOI 10.1371/journal.pone.0162901

Bibliografisk träff 2014-12-01

A novel cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine.

Yang MY, Lee YB, Ahn CH, Kaye J, Fine T, Kashi R, Ohne O, Smid K, Peters GJ, Kim DJ.

Anticancer Res · research support, non-u.s. gov't; journal article

Bibliografisk träff 2014-01-01

Novel developments in the use of antimetabolites.

Peters GJ.

Nucleosides Nucleotides Nucleic Acids · review; journal article · DOI 10.1080/15257770.2014.894197

Bibliografisk träff 2013-09-19

Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360).

Peters GJ, Smid K, Vecchi L, Kathmann I, Sarkisjan D, Honeywell RJ, Losekoot N, Ohne O, Orbach A, Blaugrund E, Jeong LS, Lee YB, Ahn CH, Kim DJ.

Invest New Drugs · research support, non-u.s. gov't; journal article · DOI 10.1007/s10637-013-0025-x

Bibliografisk träff 2012-05-01

Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity.

Choi WJ, Chung HJ, Chandra G, Alexander V, Zhao LX, Lee HW, Nayak A, Majik MS, Kim HO, Kim JH, Lee YB, Ahn CH, Lee SK, Jeong LS.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm3004009