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Publikationer i urvalet

17 träffar

Bibliografisk träff 2022-03-21

Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication.

Hsu JC, Laurent-Rolle M, Pawlak JB, Xia H, Kunte A, Hee JS, Lim J, Harris LD, Wood JM, Evans GB, Shi PY, Grove TL, Almo SC, Cresswell P.

Mol Cell · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.molcel.2022.02.031

Bibliografisk träff 2022-01-31

Antiviral metabolite 3'-deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19.

Mehta R, Chekmeneva E, Jackson H, Sands C, Mills E, Arancon D, Li HK, Arkell P, Rawson TM, Hammond R, Amran M, Haber A, Cooke GS, Noursadeghi M, Kaforou M, Lewis MR, Takats Z, Sriskandan S.

Med · brief-report; research support, non-u.s. gov't; journal article · DOI 10.1016/j.medj.2022.01.009

Bibliografisk träff 2021-10-18

A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide.

Passow KT, Caldwell HS, Ngo KA, Arnold JJ, Antczak NM, Narayanan A, Jose J, Sturla SJ, Cameron CE, Ciota AT, Harki DA.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.1c01481

Bibliografisk träff 2021-06-22

Structural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life.

Lachowicz JC, Gizzi AS, Almo SC, Grove TL.

Biochemistry · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.biochem.0c00958

Bibliografisk träff 2021-06-14

Chemical Synthesis of the Antiviral Nucleotide Analogue ddhCTP.

Wood JM, Evans GB, Grove TL, Almo SC, Cameron SA, Furneaux RH, Harris LD.

J Org Chem · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.joc.1c00761

Bibliografisk träff 2021-04-20

Three overlooked key functional classes for building up minimal synthetic cells.

Danchin A.

Synth Biol (Oxf) · research-article; journal article · DOI 10.1093/synbio/ysab010

Bibliografisk träff 2020-09-16

Prokaryotic viperins produce diverse antiviral molecules.

Bernheim A, Millman A, Ofir G, Meitav G, Avraham C, Avraham C, Shomar H, Rosenberg MM, Tal N, Melamed S, Amitai G, Sorek R.

Nature · research-article; journal article · DOI 10.1038/s41586-020-2762-2

Bibliografisk träff 2020-06-30

Viperin Reveals Its True Function.

Rivera-Serrano EE, Gizzi AS, Arnold JJ, Grove TL, Almo SC, Cameron CE.

Annu Rev Virol · research-article; review; journal article · DOI 10.1146/annurev-virology-011720-095930

Bibliografisk träff 2020-06-16

Viperin: An ancient radical SAM enzyme finds its place in modern cellular metabolism and innate immunity.

Ghosh S, Marsh ENG.

J Biol Chem · review-article; review; journal article; research support, n.i.h., extramural · DOI 10.1074/jbc.rev120.012784

Bibliografisk träff 2020-04-20

ddhCTP produced by the radical-SAM activity of RSAD2 (viperin) inhibits the NAD<sup>+</sup> -dependent activity of enzymes to modulate metabolism.

Honarmand Ebrahimi K, Vowles J, Browne C, McCullagh J, James WS.

FEBS Lett · research support, non-u.s. gov't; journal article · DOI 10.1002/1873-3468.13778

Bibliografisk träff 2020-03-02

Viperin, through its radical-SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication.

Ebrahimi KH, Howie D, Rowbotham JS, McCullagh J, Armstrong FA, James WS.

FEBS Lett · research support, non-u.s. gov't; journal article · DOI 10.1002/1873-3468.13761

Bibliografisk träff 2020-02-27

Mechanism of Diol Dehydration by a Promiscuous Radical-SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2).

Honarmand Ebrahimi K, Rowbotham JS, McCullagh J, James WS.

Chembiochem · research support, non-u.s. gov't; journal article · DOI 10.1002/cbic.201900776

Bibliografisk träff 2020-01-30

Interactions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation.

Ghosh S, Patel AM, Grunkemeyer TJ, Dumbrepatil AB, Zegalia K, Kennedy RT, Marsh ENG.

Biochemistry · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.biochem.9b01090

Bibliografisk träff 2020-01-24

Targeting viperin to the mitochondrion inhibits the thiolase activity of the trifunctional enzyme complex.

Dumbrepatil AB, Zegalia KA, Sajja K, Kennedy RT, Marsh ENG.

J Biol Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1074/jbc.ra119.011526

Bibliografisk träff 2020-01-16

Structural Basis of the Substrate Selectivity of Viperin.

Fenwick MK, Su D, Dong M, Lin H, Ealick SE.

Biochemistry · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.biochem.9b00741

Bibliografisk träff 2019-03-14

Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis.

Dumbrepatil AB, Ghosh S, Zegalia KA, Malec PA, Hoff JD, Kennedy RT, Marsh ENG.

J Biol Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1074/jbc.ra119.007719

Bibliografisk träff 2018-06-20

A naturally occurring antiviral ribonucleotide encoded by the human genome.

Gizzi AS, Grove TL, Arnold JJ, Jose J, Jangra RK, Garforth SJ, Du Q, Cahill SM, Dulyaninova NG, Love JD, Chandran K, Bresnick AR, Cameron CE, Almo SC.

Nature · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/s41586-018-0238-4