High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity.
Lu J, Sun PD.
J Biol Chem · research support, n.i.h., intramural; research-article; journal article · DOI 10.1074/jbc.ra120.015303 PUBLIKATIONSREGISTRET
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Publikationer i urvalet
13 träffarThe angiotensin-converting enzyme 2/angiotensin (1-7)/mas axis protects against pyroptosis in LPS-induced lung injury by inhibiting NLRP3 activation.
Huang H, Wang J, Liu Z, Gao F.
Arch Biochem Biophys · retracted publication; research support, non-u.s. gov't; journal article · DOI 10.1016/j.abb.2020.108562ACE2 Attenuates Epithelial-Mesenchymal Transition in MLE-12 Cells Induced by Silica.
Li S, Li Y, Xu H, Wei Z, Yang Y, Jin F, Zhang M, Wang C, Song W, Huo J, Zhao J, Yang X, Yang F.
Drug Des Devel Ther · research-article; journal article · DOI 10.2147/dddt.s252351Angiotensin-converting enzyme 2 attenuates inflammatory response and oxidative stress in hyperoxic lung injury by regulating NF-κB and Nrf2 pathways.
Fang Y, Gao F, Liu Z.
QJM · journal article · DOI 10.1093/qjmed/hcz206Angiotensin-converting enzyme 2 regulates autophagy in acute lung injury through AMPK/mTOR signaling.
Zhang X, Zheng J, Yan Y, Ruan Z, Su Y, Wang J, Huang H, Zhang Y, Wang W, Gao J, Chi Y, Lu X, Liu Z.
Arch Biochem Biophys · research support, non-u.s. gov't; journal article · DOI 10.1016/j.abb.2019.07.026Angiotensin-converting enzyme 2 activation suppresses pulmonary vascular remodeling by inducing apoptosis through the Hippo signaling pathway in rats with pulmonary arterial hypertension.
Yan D, Li G, Zhang Y, Liu Y.
Clin Exp Hypertens · journal article · DOI 10.1080/10641963.2019.1583247Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-κB signaling pathways.
Li Y, Zeng Z, Cao Y, Liu Y, Ping F, Liang M, Xue Y, Xi C, Zhou M, Jiang W.
Sci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/srep27911Angiotensin converting enzyme versus angiotensin converting enzyme-2 selectivity of MLN-4760 and DX600 in human and murine bone marrow-derived cells.
Joshi S, Balasubramanian N, Vasam G, Jarajapu YP.
Eur J Pharmacol · comparative study; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ejphar.2016.01.007Effects of the ACE2 inhibitor GL1001 on acute dextran sodium sulfate-induced colitis in mice.
Byrnes JJ, Gross S, Ellard C, Connolly K, Donahue S, Picarella D.
Inflamm Res · journal article · DOI 10.1007/s00011-009-0053-3Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats.
Diz DI, Garcia-Espinosa MA, Gegick S, Tommasi EN, Ferrario CM, Ann Tallant E, Chappell MC, Gallagher PE.
Exp Physiol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1113/expphysiol.2007.040261Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2.
Mores A, Matziari M, Beau F, Cuniasse P, Yiotakis A, Dive V.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm701275zThiol-based angiotensin-converting enzyme 2 inhibitors: P1' modifications for the exploration of the S1' subsite.
Deaton DN, Graham KP, Gross JW, Miller AB.
Bioorg Med Chem Lett · brief-report; journal article · DOI 10.1016/j.bmcl.2008.01.046ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW.
J Biol Chem · research-article; journal article · DOI 10.1074/jbc.m311191200