Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases.
Adams DR, Pyne S, Pyne NJ.
Cell Signal · review; journal article · DOI 10.1016/j.cellsig.2020.109806 PUBLIKATIONSREGISTRET
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Greig FH, Nather K, Ballantyne MD, Kazi ZH, Alganga H, Ewart MA, Zaborska KE, Fertig B, Pyne NJ, Pyne S, Kennedy S.
Eur J Pharmacol · research-article; journal article · DOI 10.1016/j.ejphar.2018.10.027Identification of selective inhibitors of sphingosine kinases 1 and 2 through a structure-activity relationship study of 4-epi-jaspine B.
Ohno H, Honda M, Hamada N, Miyagaki J, Iwata A, Otsuki K, Maruyama T, Nakamura S, Nakanishi I, Inuki S, Fujii N, Oishi S.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2017.03.059Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis.
Barbour M, McNaughton M, Boomkamp SD, MacRitchie N, Jiang HR, Pyne NJ, Pyne S.
Br J Pharmacol · research-article; journal article · DOI 10.1111/bph.13670Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors.
Congdon MD, Kharel Y, Brown AM, Lewis SN, Bevan DR, Lynch KR, Santos WL.
ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.5b00304Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors.
Patwardhan NN, Morris EA, Kharel Y, Raje MR, Gao M, Tomsig JL, Lynch KR, Santos WL.
J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm501760dImportance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors.
Plano D, Amin S, Sharma AK.
J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/jm4011687Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4.
Ohotski J, Rosen H, Bittman R, Pyne S, Pyne NJ.
Cell Signal · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1016/j.cellsig.2014.01.023The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells.
Tonelli F, Alossaimi M, Natarajan V, Gorshkova I, Berdyshev E, Bittman R, Watson DG, Pyne S, Pyne NJ.
Biomolecules · research-article; journal article · DOI 10.3390/biom3020316The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.
Tonelli F, Alossaimi M, Williamson L, Tate RJ, Watson DG, Chan E, Bittman R, Pyne NJ, Pyne S.
Br J Pharmacol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1111/bph.12035The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells.
Watson DG, Tonelli F, Alossaimi M, Williamson L, Chan E, Gorshkova I, Berdyshev E, Bittman R, Pyne NJ, Pyne S.
Cell Signal · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.cellsig.2013.01.002Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells.
Byun HS, Pyne S, Macritchie N, Pyne NJ, Bittman R.
Medchemcomm · research-article; journal article · DOI 10.1039/c3md00201b(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.
Lim KG, Sun C, Bittman R, Pyne NJ, Pyne S.
Cell Signal · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.cellsig.2011.05.010Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.
Sanchez T, Estrada-Hernandez T, Paik JH, Wu MT, Venkataraman K, Brinkmann V, Claffey K, Hla T.
J Biol Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1074/jbc.m306896200