Structural and molecular insights of two unique enzymes involved in the biosynthesis of a natural halogenated nitrile.
Chen CC, Li H, Huang JW, Guo RT.
FEBS J · journal article · DOI 10.1111/febs.17279 PUBLIKATIONSREGISTRET
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9 träffarA single diiron enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile.
Adak S, Ye N, Calderone LA, Duan M, Lubeck W, Schäfer RJB, Lukowski AL, Houk KN, Pandelia ME, Drennan CL, Moore BS.
Nat Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/s41557-024-01603-zThe structural and functional investigation into an unusual nitrile synthase.
Li H, Huang JW, Dai L, Zheng H, Dai S, Zhang Q, Yao L, Yang Y, Yang Y, Min J, Guo RT, Chen CC.
Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41467-023-43285-0More than just an eagle killer: The freshwater cyanobacterium <i>Aetokthonos hydrillicola</i> produces highly toxic dolastatin derivatives.
Schwark M, Martínez Yerena JA, Röhrborn K, Hrouzek P, Divoká P, Štenclová L, Delawská K, Enke H, Vorreiter C, Wiley F, Sippl W, Sobotka R, Saha S, Wilde SB, Mareš J, Niedermeyer THJ.
Proc Natl Acad Sci U S A · research support, non-u.s. gov't; research-article; journal article · DOI 10.1073/pnas.2219230120Occurrence of aetokthonotoxin producer in natural samples - A PCR protocol for easy detection.
Štenclová L, Wilde SB, Schwark M, Cullen JL, McWhorter SA, Niedermeyer THJ, Henderson WM, Mareš J.
Harmful Algae · research-article; journal article · DOI 10.1016/j.hal.2023.102425From Tryptophan to Toxin: Nature's Convergent Biosynthetic Strategy to Aetokthonotoxin.
Adak S, Lukowski AL, Schäfer RJB, Moore BS.
J Am Chem Soc · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jacs.1c12778Total Synthesis of Aetokthonotoxin, the Cyanobacterial Neurotoxin Causing Vacuolar Myelinopathy.
Ricardo MG, Schwark M, Llanes D, Niedermeyer THJ, Westermann B.
Chemistry · brief-report; journal article · DOI 10.1002/chem.202101848Aktuell.
Baunach M, Graw J, Hintzsche H.
Biospektrum (Heidelb) · news · DOI 10.1007/s12268-021-1585-5Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy.
Breinlinger S, Phillips TJ, Haram BN, Mareš J, Martínez Yerena JA, Hrouzek P, Sobotka R, Henderson WM, Schmieder P, Williams SM, Lauderdale JD, Wilde HD, Gerrin W, Kust A, Washington JW, Wagner C, Geier B, Liebeke M, Enke H, Niedermeyer THJ, Wilde SB.
Science · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1126/science.aax9050