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Publikationer i urvalet

12 träffar

Bibliografisk träff 2024-11-01

Machine learning-enabled virtual screening indicates the anti-tuberculosis activity of aldoxorubicin and quarfloxin with verification by molecular docking, molecular dynamics simulations, and biological evaluations.

Zheng S, Gu Y, Gu Y, Zhao Y, Li L, Wang M, Jiang R, Yu X, Chen T, Li J.

Brief Bioinform · research-article; journal article · DOI 10.1093/bib/bbae696

Bibliografisk träff 2023-11-24

Effects of the G-quadruplex-binding drugs quarfloxin and CX-5461 on the malaria parasite Plasmodium falciparum.

Craven HM, Nettesheim G, Cicuta P, Blagborough AM, Merrick CJ.

Int J Parasitol Drugs Drug Resist · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.ijpddr.2023.11.007

Bibliografisk träff 2023-06-18

A synthetic lethal approach to drug targeting of G-quadruplexes based on CX-5461.

Jin M, Hurley LH, Xu H.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2023.129384

Bibliografisk träff 2022-10-03

A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461 (Pidnarulex).

Xu H, Hurley LH.

Bioorg Med Chem Lett · research support, non-u.s. gov't; review; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2022.129016

Bibliografisk träff 2018-11-04

CX-3543 Promotes Cell Apoptosis through Downregulation of CCAT1 in Colon Cancer Cells.

Yao YX, Xu BH, Zhang Y.

Biomed Res Int · research-article; journal article · DOI 10.1155/2018/9701957

Bibliografisk träff 2018-02-23

G-Quadruplex DNA Motifs in the Malaria Parasite Plasmodium falciparum and Their Potential as Novel Antimalarial Drug Targets.

Harris LM, Monsell KR, Noulin F, Famodimu MT, Smargiasso N, Damblon C, Horrocks P, Merrick CJ.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.01828-17

Bibliografisk träff 2017-03-06

Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.

Kerry LE, Pegg EE, Cameron DP, Budzak J, Poortinga G, Hannan KM, Hannan RD, Rudenko G.

PLoS Negl Trop Dis · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pntd.0005432

Bibliografisk träff 2017-02-17

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S.

Nat Commun · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/ncomms14432

Bibliografisk träff 2013-10-08

G-quadruplex structures in the human genome as novel therapeutic targets.

Bidzinska J, Cimino-Reale G, Zaffaroni N, Folini M.

Molecules · research support, non-u.s. gov't; review-article; review; journal article · DOI 10.3390/molecules181012368

Bibliografisk träff 2010-06-01

Targeting MYC Expression through G-Quadruplexes.

Brooks TA, Hurley LH.

Genes Cancer · research-article; journal article · DOI 10.1177/1947601910377493

Bibliografisk träff 2009-09-08

Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis.

Drygin D, Siddiqui-Jain A, O'Brien S, Schwaebe M, Lin A, Bliesath J, Ho CB, Proffitt C, Trent K, Whitten JP, Lim JK, Von Hoff D, Anderes K, Rice WG.

Cancer Res · research support, non-u.s. gov't; journal article · DOI 10.1158/0008-5472.can-09-1304

Bibliografisk träff 2007-01-01

Gateways to clinical trials.

Bayés M, Rabasseda X, Prous JR.

Methods Find Exp Clin Pharmacol · bibliography; journal article