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Publikationer i urvalet

50 träffar

Bibliografisk träff 2022-03-11

C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators.

Ntungwe EN, Stojanov SJ, Duarte NM, Candeias NR, Díaz-Lanza AM, Vágvölgyi M, Hunyadi A, Pešić M, Rijo P.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.1c00711

Bibliografisk träff 2022-02-25

Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.

Shi W, Zhang P, Zou F, Zhou J, Yin Z, Cai Z, Ghaleb H, Jiang Y, Huang W, Liu Y, Qiu Q, Qian H.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114231

Bibliografisk träff 2022-02-19

Design, synthesis, and tumor drug resistance reversal activity of novel hederagenin derivatives modified by nitrogen-containing heterocycles.

Huang W, Wang Y, Xu S, Qiao H, Cheng H, Wang L, Liu S, Tian Q, Wang R, Wang H, Bi Y.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114207

Bibliografisk träff 2021-09-21

Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors.

Yuan S, Wang B, Dai QQ, Zhang XN, Zhang JY, Zuo JH, Liu H, Chen ZS, Li GB, Wang S, Liu HM, Yu B.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c01452

Bibliografisk träff 2021-09-08

Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.

Wu CP, Li YQ, Hung TH, Chang YT, Huang YH, Wu YS.

J Nat Prod · journal article · DOI 10.1021/acs.jnatprod.1c00584

Bibliografisk träff 2021-05-03

Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P-gp- and BCRP-Mediated Multidrug Resistance.

Qiu Q, Zou F, Li H, Shi W, Zhou D, Zhang P, Li T, Yin Z, Cai Z, Jiang Y, Huang W, Qian H.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c00246

Bibliografisk träff 2021-03-17

Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.

Smolinski MP, Urgaonkar S, Pitzonka L, Cutler M, Lee G, Suh KH, Lau JYN.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.0c01826

Bibliografisk träff 2020-12-17

Design, synthesis, and biological evaluation of hederagenin derivatives with improved aqueous solubility and tumor resistance reversal activity.

Wang B, Liu S, Huang W, Ma M, Chen X, Zeng W, Liang K, Wang H, Bi Y, Li X.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.113107

Bibliografisk träff 2020-07-19

Mdm2 inhibitors as a platform for the design of P-glycoprotein inhibitors.

Grigoreva T, Romanova A, Sagaidak A, Vorona S, Novikova D, Tribulovich V.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2020.127424

Bibliografisk träff 2020-05-04

Novel curcumin derivatives as P-glycoprotein inhibitors: Molecular modeling, synthesis and sensitization of multidrug resistant cells to doxorubicin.

Sagnou M, Novikov FN, Ivanova ES, Alexiou P, Stroylov VS, Titov IY, Tatarskiy VV, Vagida MS, Pelecanou M, Shtil AA, Chilov GG.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112331

Bibliografisk träff 2020-04-29

Licochalcone A Selectively Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs.

Wu CP, Lusvarghi S, Hsiao SH, Liu TC, Li YQ, Huang YH, Hung TH, Ambudkar SV.

J Nat Prod · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jnatprod.9b01022

Bibliografisk träff 2020-02-10

Tariquidar-related triazoles as potent, selective and stable inhibitors of ABCG2 (BCRP).

Antoni F, Bause M, Scholler M, Bauer S, Stark SA, Jackson SM, Manolaridis I, Locher KP, König B, Buschauer A, Bernhardt G.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112133

Bibliografisk träff 2020-02-06

Further exploration of DVD-445 as a lead thioredoxin reductase (TrxR) inhibitor for cancer therapy: Optimization of potency and evaluation of anticancer potential.

Jovanović M, Zhukovsky D, Podolski-Renić A, Žalubovskis R, Dar'in D, Sharoyko V, Tennikova T, Pešić M, Krasavin M.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112119

Bibliografisk träff 2019-09-12

Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.

Zhu X, Wong ILK, Chan KF, Cui J, Law MC, Chong TC, Hu X, Chow LMC, Chan TH.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.9b00963

Bibliografisk träff 2019-06-06

Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells.

Kairuki M, Qiu Q, Pan M, Li Q, Zhou J, Ghaleb H, Huang W, Qian H, Jiang C.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2019.06.013

Bibliografisk träff 2018-10-16

Synthesis and biological evaluation of novel H6 analogues as drug resistance reversal agents.

Wang X, Ren QW, Liu XX, Yang YT, Wang BH, Zhai R, Qi JG, Tian JW, Wang HB, Bi Y.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.10.033

Bibliografisk träff 2018-07-25

Tariquidar-Related Chalcones and Ketones as ABCG2 Modulators.

Peña-Solórzano D, Scholler M, Bernhardt G, Buschauer A, König B, Ochoa-Puentes C.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.8b00289

Bibliografisk träff 2018-04-18

New Inhibitors of Breast Cancer Resistance Protein (ABCG2) Containing a 2,4-Disubstituted Pyridopyrimidine Scaffold.

Krapf MK, Gallus J, Vahdati S, Wiese M.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.7b01012

Bibliografisk träff 2018-04-03

Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as P-glycoprotein-mediated multidrug resistance inhibitors.

Gao Y, Shi W, Cui J, Liu C, Bi X, Li Z, Huang W, Wang G, Qian H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2018.03.045

Bibliografisk träff 2018-02-10

New antitumor anthra[2,3-b]furan-3-carboxamides: Synthesis and structure-activity relationship.

Tikhomirov AS, Lin CY, Volodina YL, Dezhenkova LG, Tatarskiy VV, Schols D, Shtil AA, Kaur P, Chueh PJ, Shchekotikhin AE.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.02.027

Bibliografisk träff 2018-02-05

Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents.

Dei S, Coronnello M, Bartolucci G, Manetti D, Romanelli MN, Udomtanakunchai C, Salerno M, Teodori E.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.01.092

Bibliografisk träff 2017-12-28

Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment.

Waghray D, Zhang Q.

J Med Chem · research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.7b01457

Bibliografisk träff 2017-06-13

Synthesis and biological evaluation of JL-A7 derivatives as potent ABCB1 inhibitors.

Pan M, Cui J, Jiao L, Ghaleb H, Liao C, Zhou J, Kairuki M, Lin H, Huang W, Qian H.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2017.06.015

Bibliografisk träff 2017-01-13

N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy.

Teodori E, Dei S, Coronnello M, Floriddia E, Bartolucci G, Manetti D, Romanelli MN, Santo Domingo Porqueras D, Salerno M.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.01.019

Bibliografisk träff 2016-08-09

Hernandezine, a Bisbenzylisoquinoline Alkaloid with Selective Inhibitory Activity against Multidrug-Resistance-Linked ATP-Binding Cassette Drug Transporter ABCB1.

Hsiao SH, Lu YJ, Yang CC, Tuo WC, Li YQ, Huang YH, Hsieh CH, Hsieh CH, Hung TH, Wu CP.

J Nat Prod · journal article · DOI 10.1021/acs.jnatprod.6b00597

Bibliografisk träff 2016-06-21

Jatrophane Diterpenoids as Modulators of P-Glycoprotein-Dependent Multidrug Resistance (MDR): Advances of Structure-Activity Relationships and Discovery of Promising MDR Reversal Agents.

Zhu J, Wang R, Lou L, Li W, Tang G, Bu X, Yin S.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.6b00605

Bibliografisk träff 2015-12-13

Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization.

Obreque-Balboa JE, Sun Q, Bernhardt G, König B, Buschauer A.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2015.12.010

Bibliografisk träff 2015-07-10

Reversal of P-gp and BCRP-mediated MDR by tariquidar derivatives.

Li XQ, Wang L, Lei Y, Hu T, Zhang FL, Cho CH, To KK.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2015.06.049

Bibliografisk träff 2015-02-11

Discovery of anthranilamides as a novel class of inhibitors of neurotropic alphavirus replication.

Barraza SJ, Delekta PC, Sindac JA, Dobry CJ, Xiang J, Keep RF, Miller DJ, Larsen SD.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2015.01.054

Bibliografisk träff 2014-02-21

SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity.

Nesi G, Colabufo NA, Contino M, Perrone MG, Digiacomo M, Perrone R, Lapucci A, Macchia M, Rapposelli S.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2014.02.051