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Publikationer i urvalet

19 träffar

Bibliografisk träff 2021-05-14

A small-molecule Psora-4 acts as a caloric restriction mimetic to promote longevity in C. elegans.

Admasu TD, Barardo D, Ng LF, Batchu KC, Cazenave-Gassiot A, Wenk MR, Gruber J.

Geroscience · research support, non-u.s. gov't; research-article; journal article · DOI 10.1007/s11357-021-00374-6

Bibliografisk träff 2020-12-21

Data describing the effects of potassium channels modulators on outward currents measured in human lymphoma cell lines.

Montalbano A, Sala C, Abrardo C, Murciano N, Jahanfar F, D'Amico M, Bertoni F, Becchetti A, Arcangeli A.

Data Brief · data-paper; journal article · DOI 10.1016/j.dib.2020.106668

Bibliografisk träff 2018-10-23

Lipid profiling of C. elegans strains administered pro-longevity drugs and drug combinations.

Admasu TD, Batchu KC, Ng LF, Cazenave-Gassiot A, Wenk MR, Gruber J.

Sci Data · research support, non-u.s. gov't; dataset; data-paper; journal article; research support, n.i.h., extramural · DOI 10.1038/sdata.2018.231

Bibliografisk träff 2017-09-01

Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells.

Venturini E, Leanza L, Azzolini M, Kadow S, Mattarei A, Weller M, Tabatabai G, Edwards MJ, Zoratti M, Paradisi C, Szabò I, Gulbins E, Becker KA.

Neurosignals · research support, non-u.s. gov't; journal article · DOI 10.1159/000480643

Bibliografisk träff 2017-02-05

Angiotensin II reduces the surface abundance of K<sub>V</sub> 1.5 channels in arterial myocytes to stimulate vasoconstriction.

Kidd MW, Bulley S, Jaggar JH.

J Physiol · journal article; research support, n.i.h., extramural · DOI 10.1113/jp272893

Bibliografisk träff 2016-11-21

Contribution of K<sub>V</sub>1.5 Channel to Hydrogen Peroxide-Induced Human Arteriolar Dilation and Its Modulation by Coronary Artery Disease.

Nishijima Y, Cao S, Chabowski DS, Korishettar A, Ge A, Zheng X, Sparapani R, Gutterman DD, Zhang DX.

Circ Res · research-article; journal article · DOI 10.1161/circresaha.116.309491

Bibliografisk träff 2015-05-15

Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells.

Zhou YY, Hou GQ, He SW, Xiao Z, Xu HJ, Qiu YT, Jiang S, Zheng H, Li ZY.

CNS Neurosci Ther · research support, non-u.s. gov't; research-article; journal article · DOI 10.1111/cns.12402

Bibliografisk träff 2013-11-13

A pharmacological network for lifespan extension in Caenorhabditis elegans.

Ye X, Linton JM, Schork NJ, Buck LB, Petrascheck M.

Aging Cell · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1111/acel.12163

Bibliografisk träff 2013-08-01

Channels: Sticking to nooks and crannies.

Wulff H, Yarov-Yarovoy V.

Nat Chem Biol · comment; news · DOI 10.1038/nchembio.1292

Bibliografisk träff 2013-06-02

Side pockets provide the basis for a new mechanism of Kv channel-specific inhibition.

Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MS, Sanguinetti MC, Baukrowitz T, Decher N.

Nat Chem Biol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/nchembio.1271

Bibliografisk träff 2013-02-21

Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia.

Leanza L, Trentin L, Becker KA, Frezzato F, Zoratti M, Semenzato G, Gulbins E, Szabo I.

Leukemia · letter; research support, non-u.s. gov't · DOI 10.1038/leu.2013.56

Bibliografisk träff 2012-11-29

Ion channels as therapeutic targets: a drug discovery perspective.

Bagal SK, Brown AD, Cox PJ, Omoto K, Owen RM, Pryde DC, Sidders B, Skerratt SE, Stevens EB, Storer RI, Swain NA.

J Med Chem · review; journal article · DOI 10.1021/jm3011433

Bibliografisk träff 2010-10-07

N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 inhibitors. Part 1.

Haffner CD, Thomson SA, Guo Y, Schaller LT, Boggs S, Dickerson S, Gobel J, Gillie D, Condreay JP.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2010.09.132

Bibliografisk träff 2010-09-01

Voltage-gated potassium channel Kv1.3 blocker as a potential treatment for rat anti-glomerular basement membrane glomerulonephritis.

Hyodo T, Oda T, Kikuchi Y, Higashi K, Kushiyama T, Yamamoto K, Yamada M, Suzuki S, Hokari R, Kinoshita M, Seki S, Fujinaka H, Yamamoto T, Miura S, Kumagai H.

Am J Physiol Renal Physiol · article-commentary; journal article; research support, n.i.h., extramural · DOI 10.1152/ajprenal.00374.2010

Bibliografisk träff 2009-05-01

Loss of cerebrovascular Shaker-type K(+) channels: a shared vasodilator defect of genetic and renal hypertensive rats.

Tobin AA, Joseph BK, Al-Kindi HN, Albarwani S, Madden JA, Nemetz LT, Rusch NJ, Rhee SW.

Am J Physiol Heart Circ Physiol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1152/ajpheart.00991.2008

Bibliografisk träff 2008-07-01

Transient 5-(4-phenylbutoxy)psoralen (PAP-1) treatment dissociates developing pathologies in autoimmune optic neuritis into two distinct pathology profiles.

Stokely ME, Garg P, Bhat MA, Koulen P.

J Neurosci Res · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1002/jnr.21645

Bibliografisk träff 2005-08-11

Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases.

Schmitz A, Sankaranarayanan A, Azam P, Schmidt-Lassen K, Homerick D, Hänsel W, Wulff H.

Mol Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1124/mol.105.015669

Bibliografisk träff 2005-03-01

5-(3-Phenylpropoxy)psoralen and 5-(4-phenylbutoxy)psoralen: mechanistic studies on phototoxicity.

Bode CW, Hänsel W.

Pharmazie · journal article

Bibliografisk träff 2004-06-01

Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators.

Vennekamp J, Wulff H, Beeton C, Calabresi PA, Grissmer S, Hänsel W, Chandy KG.

Mol Pharmacol · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1124/mol.65.6.1364