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Publikationer i urvalet

23 träffar

Bibliografisk träff 2018-04-06

Heteronemin, a marine natural product, sensitizes acute myeloid leukemia cells towards cytarabine chemotherapy by regulating farnesylation of Ras.

Saikia M, Retnakumari AP, Anwar S, Anto NP, Mittal R, Shah S, Pillai KS, Balachandran VS, Peter V, Thomas R, Anto RJ.

Oncotarget · research-article; journal article · DOI 10.18632/oncotarget.24771

Bibliografisk träff 2012-07-26

Prenyltransferases regulate CD20 protein levels and influence anti-CD20 monoclonal antibody-mediated activation of complement-dependent cytotoxicity.

Winiarska M, Nowis D, Bil J, Glodkowska-Mrowka E, Muchowicz A, Wanczyk M, Bojarczuk K, Dwojak M, Firczuk M, Wilczek E, Wachowska M, Roszczenko K, Miaczynska M, Chlebowska J, Basak GW, Golab J.

J Biol Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1074/jbc.m112.374751

Bibliografisk träff 2012-06-21

Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation.

Spindler SR, Li R, Dhahbi JM, Yamakawa A, Mote P, Bodmer R, Ocorr K, Williams RT, Wang Y, Ablao KP.

PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0039581

Bibliografisk träff 2012-02-14

Propiconazole-enhanced hepatic cell proliferation is associated with dysregulation of the cholesterol biosynthesis pathway leading to activation of Erk1/2 through Ras farnesylation.

Murphy LA, Moore T, Nesnow S.

Toxicol Appl Pharmacol · journal article · DOI 10.1016/j.taap.2012.02.003

Bibliografisk träff 2008-10-18

Delayed rejection of MHC class II-disparate skin allografts in mice treated with farnesyltransferase inhibitors.

Gaylo AE, Laux KS, Batzel EJ, Berg ME, Field KA.

Transpl Immunol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.trim.2008.09.011

Bibliografisk träff 2008-05-28

Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway.

Sharyo S, Yokota-Ikeda N, Mori M, Kumagai K, Uchida K, Ito K, Burne-Taney MJ, Rabb H, Ikeda M.

Kidney Int · research support, non-u.s. gov't; journal article · DOI 10.1038/ki.2008.210

Bibliografisk träff 2008-05-19

Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas.

Field KA, Charoenthongtrakul S, Bishop JM, Refaeli Y.

Mol Cancer · research-article; journal article; research support, n.i.h., extramural · DOI 10.1186/1476-4598-7-39

Bibliografisk träff 2008-05-01

A combined treatment of HeLa cells with the farnesyl protein transferase inhibitor L-744,832 and cisplatin significantly increases the therapeutic effect as compared to cisplatin monotherapy.

Wesierska-Gadek J, Kramer MP, Schmid G.

J Cell Biochem · journal article · DOI 10.1002/jcb.21612

Bibliografisk träff 2005-10-13

Effect of the farnesyl transferase inhibitor L-744,832 on the colon cancer cell line DLD-1 and its combined use with radiation and 5-FU.

Kavgaci H, Ozdemir F, Ovali E, Yavuz A, Yavuz M, Aydin F.

Chemotherapy · evaluation study; journal article · DOI 10.1159/000088954

Bibliografisk träff 2005-06-01

The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells.

Pei XY, Dai Y, Rahmani M, Li W, Dent P, Grant S.

Clin Cancer Res · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1158/1078-0432.ccr-04-2346

Bibliografisk träff 2004-05-01

Potentiated antitumor effects of a combination therapy with a farnesyltransferase inhibitor L-744,832 and butyrate in vitro.

Kopec M, Strusinska K, Legat M, Makowski M, Jakobisiak M, Golab J.

Oncol Rep · journal article · DOI 10.3892/or.11.5.1127

Bibliografisk träff 2002-11-01

Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2.

Alcock RA, Dey S, Chendil D, Inayat MS, Mohiuddin M, Hartman G, Chatfield LK, Gallicchio VS, Ahmed MM.

Oncogene · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1038/sj.onc.1205948

Bibliografisk träff 2002-06-01

Reversion of RhoC GTPase-induced inflammatory breast cancer phenotype by treatment with a farnesyl transferase inhibitor.

van Golen KL, Bao L, DiVito MM, Wu Z, Prendergast GC, Merajver SD.

Mol Cancer Ther · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article

Bibliografisk träff 2000-05-01

Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.

Omer CA, Chen Z, Diehl RE, Conner MW, Chen HY, Trumbauer ME, Gopal-Truter S, Seeburger G, Bhimnathwala H, Abrams MT, Davide JP, Ellis MS, Gibbs JB, Greenberg I, Koblan KS, Kral AM, Liu D, Lobell RB, Miller PJ, Mosser SD, O'Neill TJ, Rands E, Schaber MD, Senderak ET, Oliff A, Kohl NE.

Cancer Res · journal article

Bibliografisk träff 2000-05-01

K-Ras-independent effects of the farnesyl transferase inhibitor L-744,832 on cyclin B1/Cdc2 kinase activity, G2/M cell cycle progression and apoptosis in human pancreatic ductal adenocarcinoma cells.

Song SY, Meszoely IM, Coffey RJ, Pietenpol JA, Leach SD.

Neoplasia · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1038/sj.neo.7900088

Bibliografisk träff 2000-04-01

Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli.

Law BK, Norgaard P, Moses HL.

J Biol Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1074/jbc.275.15.10796

Bibliografisk träff 2000-01-01

A peptidomimetic inhibitor of ras functionality markedly suppresses growth of human prostate tumor xenografts in mice. Prospects for long-term clinical utility.

Sirotnak FM, Sepp-Lorenzino L, Kohl NE, Rosen N, Scher HI.

Cancer Chemother Pharmacol · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1007/s002800000126

Bibliografisk träff 1999-12-01

Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects.

Feldkamp MM, Lau N, Guha A.

Oncogene · research support, non-u.s. gov't; journal article · DOI 10.1038/sj.onc.1203105

Bibliografisk träff 1999-10-01

In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells.

Mahgoub N, Taylor BR, Gratiot M, Kohl NE, Gibbs JB, Jacks T, Shannon KM.

Blood · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1182/blood.v94.7.2469.419a01_2469_2476

Bibliografisk träff 1999-01-01

The farnesyltransferase inhibitor L-744,832 inhibits the growth of astrocytomas through a combination of antiproliferative, antiangiogenic, and proapoptotic activities.

Feldkamp MM, Lau N, Guha A.

Ann N Y Acad Sci · journal article · DOI 10.1111/j.1749-6632.1999.tb09430.x

Bibliografisk träff 1999-01-01

Treatment with farnesyl-protein transferase inhibitor induces regression of mammary tumors in transforming growth factor (TGF) alpha and TGF alpha/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis.

Nørgaard P, Law B, Joseph H, Page DL, Shyr Y, Mays D, Pietenpol JA, Kohl NE, Oliff A, Coffey RJ, Poulsen HS, Moses HL.

Clin Cancer Res · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article

Bibliografisk träff 1998-01-01

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis.

Barrington RE, Subler MA, Rands E, Omer CA, Miller PJ, Hundley JE, Koester SK, Troyer DA, Bearss DJ, Bearss DJ, Conner MW, Gibbs JB, Hamilton K, Koblan KS, Mosser SD, O'Neill TJ, Schaber MD, Senderak ET, Windle JJ, Oliff A, Kohl NE.

Mol Cell Biol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/mcb.18.1.85

Bibliografisk träff 1995-08-01

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice.

Kohl NE, Omer CA, Conner MW, Anthony NJ, Davide JP, deSolms SJ, Giuliani EA, Gomez RP, Graham SL, Hamilton K.

Nat Med · journal article · DOI 10.1038/nm0895-792