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Publikationer i urvalet

10 träffar

Bibliografisk träff 2022-05-10

Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo.

Lin Y, Wongkrajang K, Shen X, Wang P, Zhou Z, Chuprajob T, Sornkaew N, Yang N, Yang L, Lu X, Chokchaisiri R, Suksamrarn A, Zhang G, Wang F.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2022.116811

Bibliografisk träff 2018-10-03

Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities.

Yang X, Shen J, Jiang L, Li W, Yu M, Pan G, Yan Y, Zhang C, Jia W, Xiao L, Yu H, Chen H, Zheng Y, Yu L, Xie Q, Zhou L, Shao L.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.09.073

Bibliografisk träff 2011-11-30

Discovery of novel α7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs.

Kombo DC, Mazurov AA, Chewning J, Hammond PS, Tallapragada K, Hauser TA, Speake J, Yohannes D, Caldwell WS.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2011.11.090

Bibliografisk träff 2011-09-29

Docking studies of benzylidene anabaseine interactions with α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): application to the design of related α7 selective ligands.

Kombo DC, Mazurov A, Tallapragada K, Hammond PS, Chewning J, Hauser TA, Vasquez-Valdivieso M, Yohannes D, Talley TT, Taylor P, Caldwell WS.

Eur J Med Chem · research-article; journal article · DOI 10.1016/j.ejmech.2011.09.033

Bibliografisk träff 2010-02-13

A computational study of the binding of 3-(arylidene) anabaseines to two major brain nicotinic acetylcholine receptors and to the acetylcholine binding protein.

Slavov SH, Radzvilovits M, LeFrancois S, Stoyanova-Slavova IB, Soti F, Kem WR, Katritzky AR.

Eur J Med Chem · journal article; research support, n.i.h., extramural · DOI 10.1016/j.ejmech.2010.02.027

Bibliografisk träff 2009-02-07

Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.

Enz A, Feuerbach D, Frederiksen MU, Gentsch C, Hurth K, Müller W, Nozulak J, Roy BL.

Bioorg Med Chem Lett · comparative study; journal article · DOI 10.1016/j.bmcl.2009.01.073

Bibliografisk träff 2008-10-01

Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding.

Huang X, Zheng F, Stokes C, Papke RL, Zhan CG.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm800607u

Bibliografisk träff 2005-07-01

Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.

Jensen AA, Frølund B, Liljefors T, Krogsgaard-Larsen P.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/jm040219e

Bibliografisk träff 2005-04-01

Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand.

Tatsumi R, Fujio M, Satoh H, Katayama J, Takanashi S, Hashimoto K, Tanaka H.

J Med Chem · journal article · DOI 10.1021/jm049188d

Bibliografisk träff 1997-12-01

Neuronal nicotinic acetylcholine receptors as targets for drug discovery.

Holladay MW, Dart MJ, Lynch JK.

J Med Chem · review; journal article · DOI 10.1021/jm970377o